KEGG   PATHWAY: lmoy00030Help
lmoy00030                   Pathway                                

Pentose phosphate pathway - Listeria monocytogenes SLCC2479
The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
lmoy00030  Pentose phosphate pathway

Ortholog table
lmoy_M00004  Pentose phosphate pathway (Pentose phosphate cycle) [PATH:lmoy00030]
lmoy_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:lmoy00030]
lmoy_M00006  Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:lmoy00030]
lmoy_M00007  Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:lmoy00030]
Other DBs
BSID: 692888
GO: 0006098
Listeria monocytogenes SLCC2479 [GN:lmoy]
LMOSLCC2479_2428  pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:]
LMOSLCC2479_2041  zwf; glucose-6-phosphate 1-dehydrogenase [KO:K00036] [EC:]
LMOSLCC2479_0565  hypothetical protein [KO:K07404] [EC:]
LMOSLCC2479_1437  gnd; 6-phosphogluconate dehydrogenase, decarboxylating [KO:K00033] [EC:]
LMOSLCC2479_0506  ribulose-phosphate 3-epimerase family protein [KO:K01783] [EC:]
LMOSLCC2479_0512  rpe-1; ribulose-phosphate 3-epimerase [KO:K01783] [EC:]
LMOSLCC2479_2725  rpe-3; ribulose-phosphate 3-epimerase [KO:K01783] [EC:]
LMOSLCC2479_2727  putative ribulose-phosphate 3-epimerase [KO:K01783] [EC:]
LMOSLCC2479_1882  rpe-2; ribulose-phosphate 3-epimerase [KO:K01783] [EC:]
LMOSLCC2479_0744  ribulose-5-phosphate 3-epimerase [KO:K01783] [EC:]
LMOSLCC2479_2726  tkt-3; transketolase [KO:K00615] [EC:]
LMOSLCC2479_1045  transketolase, N-terminal subunit [KO:K00615] [EC:]
LMOSLCC2479_1046  putative transketolase, C-terminal subunit [KO:K00615] [EC:]
LMOSLCC2479_1365  tkt-2; transketolase [KO:K00615] [EC:]
LMOSLCC2479_0342  tkt-1; transketolase [KO:K00615] [EC:]
LMOSLCC2479_2821  talC-2; transaldolase [KO:K00616] [EC:]
LMOSLCC2479_0343  talC-1; transaldolase [KO:K00616] [EC:]
LMOSLCC2479_0988  rpiA; ribose 5-phosphate isomerase A [KO:K01807] [EC:]
LMOSLCC2479_0505  rpiB-2; ribose 5-phosphate isomerase B [KO:K01808] [EC:]
LMOSLCC2479_2728  rpiB-3; ribose 5-phosphate isomerase B [KO:K01808] [EC:]
LMOSLCC2479_2740  rpiB-4; ribose 5-phosphate isomerase B [KO:K01808] [EC:]
LMOSLCC2479_0345  rpiB-1; ribose 5-phosphate isomerase B [KO:K01808] [EC:]
LMOSLCC2479_0745  rpiB; ribose-5-phosphate isomerase B [KO:K01808] [EC:]
LMOSLCC2479_2058  deoC; deoxyribose-phosphate aldolase [KO:K01619] [EC:]
LMOSLCC2479_2017  deoB; phosphopentomutase [KO:K01839] [EC:]
LMOSLCC2479_2536  phosphoglucomutase/phosphomannomutase [KO:K01835] [EC:]
LMOSLCC2479_0516  prs-2; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:]
LMOSLCC2479_0199  prs-1; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:]
LMOSLCC2479_2032  KDPG and KHG aldolase family protein [KO:K01625] [EC:]
LMOSLCC2479_2790  gntK; gluconate kinase [KO:K00851] [EC:]
LMOSLCC2479_0359  fructose-bisphosphate aldolase, class II family [KO:K01624] [EC:]
LMOSLCC2479_2198  fructose-bisphosphate aldolase, class II family [KO:K01624] [EC:]
LMOSLCC2479_2199  fructose-bisphosphate aldolase, class II family [KO:K01624] [EC:]
LMOSLCC2479_0838  fbp; fructose-1,6-bisphosphatase [KO:K04041] [EC:]
LMOSLCC2479_1633  pfk; 6-phosphofructokinase [KO:K00850] [EC:]
C00022  Pyruvate
C00031  D-Glucose
C00117  D-Ribose 5-phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00121  D-Ribose
C00197  3-Phospho-D-glycerate
C00198  D-Glucono-1,5-lactone
C00199  D-Ribulose 5-phosphate
C00204  2-Dehydro-3-deoxy-D-gluconate
C00221  beta-D-Glucose
C00231  D-Xylulose 5-phosphate
C00257  D-Gluconic acid
C00258  D-Glycerate
C00279  D-Erythrose 4-phosphate
C00345  6-Phospho-D-gluconate
C00577  D-Glyceraldehyde
C00620  alpha-D-Ribose 1-phosphate
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C00672  2-Deoxy-D-ribose 1-phosphate
C00673  2-Deoxy-D-ribose 5-phosphate
C01151  D-Ribose 1,5-bisphosphate
C01172  beta-D-Glucose 6-phosphate
C01218  6-Phospho-2-dehydro-D-gluconate
C01236  D-Glucono-1,5-lactone 6-phosphate
C01801  Deoxyribose
C03752  2-Amino-2-deoxy-D-gluconate
C04442  2-Dehydro-3-deoxy-6-phospho-D-gluconate
C05345  beta-D-Fructose 6-phosphate
C05378  beta-D-Fructose 1,6-bisphosphate
C05382  Sedoheptulose 7-phosphate
C06019  D-arabino-Hex-3-ulose 6-phosphate
C06473  2-Keto-D-gluconic acid
C20589  D-Glucosaminate-6-phosphate
(map 3)
Nishizuka Y (ed).
[Metabolic Maps] (In Japanese)
Tokyo Kagaku Dojin (1980)
(map 4)
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
[Cellular Functions and Metabolic Maps] (In Japanese)
Tokyo Kagaku Dojin (1997)
Michal G.
Biochemical Pathways
Wiley (1999)
Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.
Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.
J Bacteriol 185:2793-801 (2003)
Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y
The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis.
J Bacteriol 188:4698-704 (2006)
Kato N, Yurimoto H, Thauer RK
The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
Biosci Biotechnol Biochem 70:10-21 (2006)
Kouril T, Wieloch P, Reimann J, Wagner M, Zaparty M, Albers SV, Schomburg D, Ruoff P, Siebers B
Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2.
FEBS J 280:1126-38 (2013)
Reher M, Schonheit P
Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.
FEBS Lett 580:1198-204 (2006)
Reher M, Fuhrer T, Bott M, Schonheit P
The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
J Bacteriol 192:964-74 (2010)
KO pathway

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