KEGG   PATHWAY: lpj03440Help
Entry
lpj03440                    Pathway                                

Name
Homologous recombination - Lactobacillus plantarum JDM1
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
lpj03440  Homologous recombination
lpj03440

Ortholog table
Module
lpj_M00260  DNA polymerase III complex, bacteria [PATH:lpj03440]
Other DBs
BSID: 105335
GO: 0000724
Organism
Lactobacillus plantarum JDM1 [GN:lpj]
Gene
JDM1_1746  recJ; single-strand DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
JDM1_0008  ssb; single-strand binding protein [KO:K03111]
JDM1_0004  recF; recombination protein F [KO:K03629]
JDM1_1657  recO; DNA repair protein RecO [KO:K03584]
JDM1_0572  recR; recombination protein RecR [KO:K06187]
JDM1_1925  recA; recombinase A [KO:K03553]
JDM1_1262  polA; DNA-directed DNA polymerase I [KO:K02335] [EC:2.7.7.7]
JDM1_1917  ruvA; holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
JDM1_1916  ruvB; Holliday junction DNA helicase B [KO:K03551] [EC:3.6.4.12]
JDM1_1367  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
JDM1_1815  recD; exodeoxyribonuclease V, alpha chain [KO:K03581] [EC:3.1.11.5]
JDM1_1597  dnaE; DNA-directed DNA polymerase III, alpha chain [KO:K02337] [EC:2.7.7.7]
JDM1_1709  polC; DNA polymerase III PolC [KO:K03763] [EC:2.7.7.7]
JDM1_0002  dnaN; DNA-directed DNA polymerase III, beta chain [KO:K02338] [EC:2.7.7.7]
JDM1_0570  dnaX; DNA-directed DNA polymerase III, gamma/tau subunit [KO:K02343] [EC:2.7.7.7]
JDM1_1783  holA; DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
JDM1_0581  holB; DNA polymerase III subunit delta' [KO:K02341] [EC:2.7.7.7]
JDM1_0674  DNA-directed DNA polymerase III, epsilon chain (putative) [KO:K02342] [EC:2.7.7.7]
JDM1_1355  priA; primosomal protein N' [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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