KEGG   PATHWAY: map00404
Entry
map00404                    Pathway                                

Name
Staurosporine biosynthesis
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
map00404  Staurosporine biosynthesis
map00404

Module
M00786  Fumitremorgin alkaloid biosynthesis, tryptophan + proline => fumitremorgin C/A [PATH:map00404]
M00789  Rebeccamycin biosynthesis, tryptophan => rebeccamycin [PATH:map00404]
M00790  Pyrrolnitrin biosynthesis, tryptophan => pyrrolnitrin [PATH:map00404]
M00805  Staurosporine biosynthesis, tryptophan => staurosporine [PATH:map00404]
M00808  Violacein biosynthesis, tryptophan => violacein [PATH:map00404]
Reference
  Authors
Sanchez C, Mendez C, Salas JA
  Title
Indolocarbazole natural products: occurrence, biosynthesis, and biological activity.
  Journal
Nat Prod Rep 23:1007-45 (2006)
DOI:10.1039/b601930g
Reference
  Authors
Onaka H, Taniguchi S, Igarashi Y, Furumai T
  Title
Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans.
  Journal
J Antibiot (Tokyo) 55:1063-71 (2002)
DOI:10.7164/antibiotics.55.1063
Reference
  Authors
Lee ME, Aswani A, Han AS, Tomlin CJ, Dueber JE
  Title
Expression-level optimization of a multi-enzyme pathway in the absence of a high-throughput assay.
  Journal
Nucleic Acids Res 41:10668-78 (2013)
DOI:10.1093/nar/gkt809
Reference
  Authors
Onaka H, Taniguchi S, Igarashi Y, Furumai T
  Title
Characterization of the biosynthetic gene cluster of rebeccamycin from Lechevalieria aerocolonigenes ATCC 39243.
  Journal
Biosci Biotechnol Biochem 67:127-38 (2003)
DOI:10.1271/bbb.67.127
Reference
PMID:9172332
  Authors
Hammer PE, Hill DS, Lam ST, Van Pee KH, Ligon JM
  Title
Four genes from Pseudomonas fluorescens that encode the biosynthesis of pyrrolnitrin.
  Journal
Appl Environ Microbiol 63:2147-54 (1997)
DOI:10.1128/AEM.63.6.2147-2154.1997
Reference
  Authors
Mundt K, Wollinsky B, Ruan HL, Zhu T, Li SM
  Title
Identification of the verruculogen prenyltransferase FtmPT3 by a combination of chemical, bioinformatic and biochemical approaches.
  Journal
Chembiochem 13:2583-92 (2012)
DOI:10.1002/cbic.201200523
Related
pathway
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis
map00523  Polyketide sugar unit biosynthesis
KO pathway
ko00404   

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