Entry Name cAMP signaling pathway
Description cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Ortholog table Other DBs Reference Authors Fimia GM, Sassone-Corsi P
Title Cyclic AMP signalling.
Journal J Cell Sci 114:1971-2 (2001)
Reference Authors Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
Title Cyclic AMP: master regulator of innate immune cell function.
Journal Reference Authors Oldenburger A, Maarsingh H, Schmidt M
Title Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.
Journal Reference Authors Ahuja M, Jha A, Maleth J, Park S, Muallem S
Title cAMP and Ca signaling in secretory epithelia: Crosstalk and synergism.
Journal Reference Authors Shirshev SV
Title Role of Epac proteins in mechanisms of cAMP-dependent immunoregulation.
Journal Reference Authors Roscioni SS, Elzinga CR, Schmidt M
Title Epac: effectors and biological functions.
Journal Reference Authors Roberts OL, Dart C
Title cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP).
Journal Reference Authors Schaub MC, Hefti MA, Zaugg M
Title Integration of calcium with the signaling network in cardiac myocytes.
Journal Reference Authors Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J
Title The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.
Journal Reference Authors Saucerman JJ, McCulloch AD
Title Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.
Journal Reference Authors Yang JH, Saucerman JJ
Title Computational models reduce complexity and accelerate insight into cardiac signaling networks.
Journal Reference Authors Taggart P, Boyett MR, Logantha S, Lambiase PD
Title Anger, emotion, and arrhythmias: from brain to heart.
Journal Reference Authors Bozzi Y, Dunleavy M, Henshall DC
Title Cell signaling underlying epileptic behavior.
Journal Reference Authors Lizcano JM, Morrice N, Cohen P
Title Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.
Journal Reference Authors Gerlo S, Kooijman R, Beck IM, Kolmus K, Spooren A, Haegeman G
Title Cyclic AMP: a selective modulator of NF-kappaB action.
Journal Reference Authors Lauder JM
Title Neurotransmitters as growth regulatory signals: role of receptors and second messengers.
Journal Reference Authors Voglis G, Tavernarakis N
Title The role of synaptic ion channels in synaptic plasticity.
Journal Reference Authors Altarejos JY, Montminy M
Title CREB and the CRTC co-activators: sensors for hormonal and metabolic signals.
Journal Reference Authors Bozzi Y, Borrelli E
Title The role of dopamine signaling in epileptogenesis.
Journal Reference Authors Ceulemans H, Bollen M
Title Functional diversity of protein phosphatase-1, a cellular economizer and reset button.
Journal Reference Authors Lipinski RJ, Gipp JJ, Zhang J, Doles JD, Bushman W
Title Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling.
Journal Reference Authors Lasala C, Schteingart HF, Arouche N, Bedecarras P, Grinspon RP, Picard JY, Josso N, di Clemente N, Rey RA
Title SOX9 and SF1 are involved in cyclic AMP-mediated upregulation of anti-Mullerian gene expression in the testicular prepubertal Sertoli cell line SMAT1.
Journal Reference Authors Rosenkranz AC, Rauch BH, Freidel K, Schror K
Title Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT.
Journal Reference Authors Lazennec G, Canaple L, Saugy D, Wahli W
Title Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators.
Journal Reference Authors Murthy KS
Title Signaling for contraction and relaxation in smooth muscle of the gut.
Journal Reference Authors Birukova AA, Zagranichnaya T, Alekseeva E, Bokoch GM, Birukov KG
Title Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection.
Journal Reference Authors Houslay MD, Milligan G
Title Tailoring cAMP-signalling responses through isoform multiplicity.
Journal Related KO pathway
