KEGG PATHWAY: map05152

PATHWAY: map05152

Entry

map05152                    Pathway

Name

Tuberculosis

Description

Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection.

Class

Human Diseases; Infectious disease: bacterial

Pathway map

map05152

Tuberculosis

Disease

H00342

Tuberculosis

Reference

PMID:21274449

Authors

Saiga H, Shimada Y, Takeda K

Title

Innate immune effectors in mycobacterial infection.

Journal

Clin Dev Immunol 2011:347594 (2011)
DOI:10.1155/2011/347594

Reference

PMID:20415982

Authors

Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y

Title

The immunology of tuberculosis: from bench to bedside.

Journal

Respirology 15:433-50 (2010)
DOI:10.1111/j.1440-1843.2010.01739.x

Reference

PMID:11932234

Authors

van Crevel R, Ottenhoff TH, van der Meer JW

Title

Innate immunity to Mycobacterium tuberculosis.

Journal

Clin Microbiol Rev 15:294-309 (2002)
DOI:10.1128/CMR.15.2.294-309.2002

Reference

PMID:18288961

Authors

Torrelles JB, Azad AK, Henning LN, Carlson TK, Schlesinger LS

Title

Role of C-type lectins in mycobacterial infections.

Journal

Curr Drug Targets 9:102-12 (2008)
DOI:10.2174/138945008783502467

Reference

PMID:17359235

Authors

Jo EK, Yang CS, Choi CH, Harding CV

Title

Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.

Journal

Cell Microbiol 9:1087-98 (2007)
DOI:10.1111/j.1462-5822.2007.00914.x

Reference

PMID:21274433

Authors

Marakalala MJ, Graham LM, Brown GD

Title

The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.

Journal

Clin Dev Immunol 2010:567571 (2010)
DOI:10.1155/2010/567571

Reference

PMID:15083155

Authors

Koul A, Herget T, Klebl B, Ullrich A

Title

Interplay between mycobacteria and host signalling pathways.

Journal

Nat Rev Microbiol 2:189-202 (2004)
DOI:10.1038/nrmicro840

Reference

PMID:20199890

Authors

Torrelles JB, Schlesinger LS

Title

Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.

Journal

Tuberculosis (Edinb) 90:84-93 (2010)
DOI:10.1016/j.tube.2010.02.003

Reference

PMID:15228522

Authors

Briken V, Porcelli SA, Besra GS, Kremer L

Title

Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.

Journal

Mol Microbiol 53:391-403 (2004)
DOI:10.1111/j.1365-2958.2004.04183.x

Reference

PMID:19563525

Authors

Baena A, Porcelli SA

Title

Evasion and subversion of antigen presentation by Mycobacterium tuberculosis.

Journal

Tissue Antigens 74:189-204 (2009)
DOI:10.1111/j.1399-0039.2009.01301.x

Reference

PMID:19369951

Authors

Flannagan RS, Cosio G, Grinstein S

Title

Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.

Journal

Nat Rev Microbiol 7:355-66 (2009)
DOI:10.1038/nrmicro2128

Reference

PMID:18541216

Authors

Pieters J

Title

Mycobacterium tuberculosis and the macrophage: maintaining a balance.

Journal

Cell Host Microbe 3:399-407 (2008)
DOI:10.1016/j.chom.2008.05.006

Reference

PMID:19634703

Authors

Scherr N, Jayachandran R, Mueller P, Pieters J

Title

Interference of Mycobacterium tuberculosis with macrophage responses.

Journal

Indian J Exp Biol 47:401-6 (2009)

Reference

PMID:16200082

Authors

Reith W, LeibundGut-Landmann S, Waldburger JM.

Title

Regulation of MHC class II gene expression by the class II transactivator.

Journal

Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708

Reference

PMID:17785780

Authors

Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A

Title

Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.

Journal

J Immunol 179:3463-71 (2007)
DOI:10.4049/jimmunol.179.6.3463

Reference

PMID:18407066

Authors

Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V

Title

Mycobacterium tuberculosis prevents inflammasome activation.

Journal

Cell Host Microbe 3:224-32 (2008)
DOI:10.1016/j.chom.2008.03.003

Reference

PMID:11378475

Authors

Shtrichman R, Samuel CE

Title

The role of gamma interferon in antimicrobial immunity.

Journal

Curr Opin Microbiol 4:251-9 (2001)
DOI:10.1016/S1369-5274(00)00199-5

Related
pathway

map00571

Lipoarabinomannan (LAM) biosynthesis

map04010

MAPK signaling pathway

map04210

Apoptosis

map04612

Antigen processing and presentation

map04620

Toll-like receptor signaling pathway

map04621

NOD-like receptor signaling pathway

map04630

JAK-STAT signaling pathway

KO pathway

ko05152

All links

Chemical substance (18)   
   KEGG COMPOUND (9)   
   KEGG GLYCAN (9)   
Gene (533443)   
   KEGG ORTHOLOGY (131)   
   RefGene (533312)   
Literature (17)   
   PubMed (17)   
All databases (533478)   

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