KEGG   PATHWAY: mbb03440Help
Entry
mbb03440                    Pathway                                

Name
Homologous recombination - Mycobacterium bovis BCG Pasteur 1173P2
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
mbb03440  Homologous recombination
mbb03440

Ortholog table
Module
mbb_M00260  DNA polymerase III complex, bacteria [PATH:mbb03440]
Other DBs
BSID: 45811
GO: 0000724
Organism
Mycobacterium bovis BCG Pasteur 1173P2 [GN:mbb]
Gene
BCG_2498  Conserved hypothetical protein [KO:K03111]
BCG_0085  ssb; Probable single-strand binding protein ssb [KO:K03111]
BCG_0003  recF_1; dna replication and repair protein recF [KO:K03629]
BCG_0033  recF_2; Dna replication and repair protein recF [KO:K03629]
BCG_2376c  Conserved hypothetical protein [KO:K03584]
BCG_3775c  recR; Recombination protein recR [KO:K06187]
BCG_2750c  recA; RecA protein [contains: endonuclease pi-mtui [KO:K03553]
BCG_1667  polA; DNA polymerase I polA [KO:K02335] [EC:2.7.7.7]
BCG_2616c  ruvA; Probable holliday junction DNA helicase ruvA [KO:K03550] [EC:3.6.4.12]
BCG_2615c  ruvB; Probable holliday junction DNA helicase ruvB [KO:K03551] [EC:3.6.4.12]
BCG_2617c  ruvC; Probable crossover junction endodeoxyribonuclease ruvC [KO:K01159] [EC:3.1.22.4]
BCG_2995c  recG; Probable atp-dependent dna helicase recG [KO:K03655] [EC:3.6.4.12]
BCG_0677c  recBa; Probable exonuclease V (beta chain) recBa [first part] [KO:K03582] [EC:3.1.11.5]
BCG_0678c  recC; PRobable exonuclease V (gamma chain) recC [KO:K03583] [EC:3.1.11.5]
BCG_0675c  recD; Probable exonuclease V (alpha chain) recD [KO:K03581] [EC:3.1.11.5]
BCG_1600  dnaE1; Probable DNA polymerase III (alpha chain) dnaE1 [KO:K02337] [EC:2.7.7.7]
BCG_0032  dnaN_2; DNA polymerase III subunit beta dnaN [KO:K02338] [EC:2.7.7.7]
BCG_0002  dnaN_1; DNA polymerase III subunit beta dnaN [KO:K02338] [EC:2.7.7.7]
BCG_3781c  dnaZX; DNA polymerase III (subunit gamma/tau) dnaZ/X [KO:K02343] [EC:2.7.7.7]
BCG_2429c  Conserved hypothetical protein [KO:K02340] [EC:2.7.7.7]
BCG_3702c  DNA polymerase [KO:K02341] [EC:2.7.7.7]
BCG_3771c  dnaQ; Putative dna polymerase III (epsilon subunit) dnaQ [KO:K02342] [EC:2.7.7.7]
BCG_2207  Conserved hypothetical protein [KO:K02342] [EC:2.7.7.7]
BCG_1463  priA; Putative primosomal protein N' priA [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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