KEGG   PATHWAY: mmu00270Help
Entry
mmu00270                    Pathway                                

Name
Cysteine and methionine metabolism - Mus musculus (mouse)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
BRITE hierarchy
Pathway map
mmu00270  Cysteine and methionine metabolism
mmu00270

Ortholog table
Module
mmu_M00034  Methionine salvage pathway [PATH:mmu00270]
mmu_M00035  Methionine degradation [PATH:mmu00270]
mmu_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:mmu00270]
Other DBs
GO: 0006534 0006555
Organism
Mus musculus (mouse) [GN:mmu]
Gene
107869  Cth; cystathionase (cystathionine gamma-lyase) [KO:K01758] [EC:4.4.1.1]
229905  Kyat3; kynurenine aminotransferase 3 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
70266  Kyat1; kynurenine aminotransferase 1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
12411  Cbs; cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
12116  Bhmt; betaine-homocysteine methyltransferase [KO:K00544] [EC:2.1.1.5]
64918  Bhmt2; betaine-homocysteine methyltransferase 2 [KO:K00547] [EC:2.1.1.10]
238505  Mtr; 5-methyltetrahydrofolate-homocysteine methyltransferase [KO:K00548] [EC:2.1.1.13]
11720  Mat1a; methionine adenosyltransferase I, alpha [KO:K00789] [EC:2.5.1.6]
232087  Mat2a; methionine adenosyltransferase II, alpha [KO:K00789] [EC:2.5.1.6]
108645  Mat2b; methionine adenosyltransferase II, beta [KO:K00789] [EC:2.5.1.6]
11702  Amd1; S-adenosylmethionine decarboxylase 1 [KO:K01611] [EC:4.1.1.50]
100041585  Amd2; S-adenosylmethionine decarboxylase 2 [KO:K01611] [EC:4.1.1.50]
20810  Srm; spermidine synthase [KO:K00797] [EC:2.5.1.16]
20603  Sms; spermine synthase [KO:K00802] [EC:2.5.1.22]
66902  Mtap; methylthioadenosine phosphorylase [KO:K00772] [EC:2.4.2.28]
67873  Mri1; methylthioribose-1-phosphate isomerase 1 [KO:K08963] [EC:5.3.1.23]
56369  Apip; APAF1 interacting protein [KO:K08964] [EC:4.2.1.109]
67870  Enoph1; enolase-phosphatase 1 [KO:K09880] [EC:3.1.3.77]
104923  Adi1; acireductone dioxygenase 1 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
234724  Tat; tyrosine aminotransferase [KO:K00815] [EC:2.6.1.5]
14204  Il4i1; interleukin 4 induced 1 [KO:K03334] [EC:1.4.3.2]
100470  Lao1; L-amino acid oxidase 1 [KO:K03334] [EC:1.4.3.2]
100328588  Il4i1b; interleukin 4 induced 1B [KO:K03334] [EC:1.4.3.2]
73988  4930438A08Rik; RIKEN cDNA 4930438A08 gene [KO:K03334] [EC:1.4.3.2]
13433  Dnmt1; DNA methyltransferase (cytosine-5) 1 [KO:K00558] [EC:2.1.1.37]
13435  Dnmt3a; DNA methyltransferase 3A [KO:K17398] [EC:2.1.1.37]
13436  Dnmt3b; DNA methyltransferase 3B [KO:K17399] [EC:2.1.1.37]
269378  Ahcy; S-adenosylhomocysteine hydrolase [KO:K01251] [EC:3.3.1.1]
229709  Ahcyl1; S-adenosylhomocysteine hydrolase-like 1 [KO:K01251] [EC:3.3.1.1]
74340  Ahcyl2; S-adenosylhomocysteine hydrolase-like 2 [KO:K01251] [EC:3.3.1.1]
11615  Gm4737; predicted gene 4737 [KO:K01251] [EC:3.3.1.1]
12035  Bcat1; branched chain aminotransferase 1, cytosolic [KO:K00826] [EC:2.6.1.42]
12036  Bcat2; branched chain aminotransferase 2, mitochondrial [KO:K00826] [EC:2.6.1.42]
268782  Agxt2; alanine-glyoxylate aminotransferase 2 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
14629  Gclc; glutamate-cysteine ligase, catalytic subunit [KO:K11204] [EC:6.3.2.2]
14630  Gclm; glutamate-cysteine ligase, modifier subunit [KO:K11205]
14854  Gss; glutathione synthetase [KO:K21456] [EC:6.3.2.3]
12583  Cdo1; cysteine dioxygenase 1, cytosolic [KO:K00456] [EC:1.13.11.20]
14718  Got1; glutamic-oxaloacetic transaminase 1, soluble [KO:K14454] [EC:2.6.1.1]
14719  Got2; glutamatic-oxaloacetic transaminase 2, mitochondrial [KO:K14455] [EC:2.6.1.1]
246221  Mpst; mercaptopyruvate sulfurtransferase [KO:K01011] [EC:2.8.1.1 2.8.1.2]
22117  Tst; thiosulfate sulfurtransferase, mitochondrial [KO:K01011] [EC:2.8.1.1 2.8.1.2]
16828  Ldha; lactate dehydrogenase A [KO:K00016] [EC:1.1.1.27]
16832  Ldhb; lactate dehydrogenase B [KO:K00016] [EC:1.1.1.27]
16833  Ldhc; lactate dehydrogenase C [KO:K00016] [EC:1.1.1.27]
106557  Ldhal6b; lactate dehydrogenase A-like 6B [KO:K00016] [EC:1.1.1.27]
17449  Mdh1; malate dehydrogenase 1, NAD (soluble) [KO:K00025] [EC:1.1.1.37]
17448  Mdh2; malate dehydrogenase 2, NAD (mitochondrial) [KO:K00026] [EC:1.1.1.37]
231691  Sds; serine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
257635  Sdsl; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
236539  Phgdh; 3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
107272  Psat1; phosphoserine aminotransferase 1 [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
Reference
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
mmu00010  Glycolysis / Gluconeogenesis
mmu00250  Alanine, aspartate and glutamate metabolism
mmu00260  Glycine, serine and threonine metabolism
mmu00290  Valine, leucine and isoleucine biosynthesis
mmu00430  Taurine and hypotaurine metabolism
mmu00480  Glutathione metabolism
mmu00620  Pyruvate metabolism
mmu00640  Propanoate metabolism
mmu00770  Pantothenate and CoA biosynthesis
mmu00920  Sulfur metabolism
KO pathway
ko00270   

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