KEGG   PATHWAY: mmu05310Help
Entry
mmu05310                    Pathway                                

Name
Asthma - Mus musculus (mouse)
Description
Asthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and airway inflammation. Inhaled allergens encounter antigen presenting cells (APC) that line the airway. Upon recognition of the antigen and activation by APC, naive T cells differentiate into TH2 cells. Activated TH2 stimulate the formation of IgE by B cells. IgE molecules bind to IgE receptors located on mast cells. The crosslinking of mast-cell-bound IgE by allergens leads to the release of biologically active mediators (histamine, leukotrienes) by means of degranulation and, so, to the immediate symptoms of allergy. Mast cells also release chemotactic factors that contribute to the recruitment of inflammatory cells, particularly eosinophils, whose proliferation and differentiation from bone marrow progenitors is promoted by IL-5. The activation of eosinophils leads to release of toxic granules and oxygen free radicals that lead to tissue damage and promote the development of chronic inflammation.
Class
Human Diseases; Immune diseases
BRITE hierarchy
Pathway map
mmu05310  Asthma
mmu05310

Ortholog table
Organism
Mus musculus (mouse) [GN:mmu]
Gene
14960  H2-Aa; histocompatibility 2, class II antigen A, alpha [KO:K06752]
14961  H2-Ab1; histocompatibility 2, class II antigen A, beta 1 [KO:K06752]
14969  H2-Eb1; histocompatibility 2, class II antigen E beta [KO:K06752]
14998  H2-DMa; histocompatibility 2, class II, locus DMa [KO:K06752]
14999  H2-DMb1; histocompatibility 2, class II, locus Mb1 [KO:K06752]
15000  H2-DMb2; histocompatibility 2, class II, locus Mb2 [KO:K06752]
15001  H2-Oa; histocompatibility 2, O region alpha locus [KO:K06752]
15002  H2-Ob; histocompatibility 2, O region beta locus [KO:K06752]
100504404  H2-Ea-ps; histocompatibility 2, class II antigen E alpha, pseudogene [KO:K06752]
16189  Il4; interleukin 4 [KO:K05430]
21947  Cd40lg; CD40 ligand [KO:K03161]
21939  Cd40; CD40 antigen [KO:K03160]
641025  CRP55H; Ig heavy chain Mem5-like [KO:K06856]
14125  Fcer1a; Fc receptor, IgE, high affinity I, alpha polypeptide [KO:K08089]
14126  Ms4a2; membrane-spanning 4-domains, subfamily A, member 2 [KO:K08090]
14127  Fcer1g; Fc receptor, IgE, high affinity I, gamma polypeptide [KO:K07983]
16198  Il9; interleukin 9 [KO:K05432]
16153  Il10; interleukin 10 [KO:K05443]
16163  Il13; interleukin 13 [KO:K05435]
16191  Il5; interleukin 5 [KO:K05428]
20292  Ccl11; chemokine (C-C motif) ligand 11 [KO:K16597]
21926  Tnf; tumor necrosis factor [KO:K03156]
16187  Il3; interleukin 3 [KO:K04736]
19074  Prg2; proteoglycan 2, bone marrow [KO:K10786]
13861  Epx; eosinophil peroxidase [KO:K10788] [EC:1.11.1.7]
Compound
C00388  Histamine
C00696  Prostaglandin D2
C02166  Leukotriene C4
C04598  2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine
C05951  Leukotriene D4
Reference
  Authors
Busse WW, Lemanske RF Jr.
  Title
Asthma.
  Journal
N Engl J Med 344:350-62 (2001)
DOI:10.1056/NEJM200102013440507
Reference
  Authors
Renauld JC.
  Title
New insights into the role of cytokines in asthma.
  Journal
J Clin Pathol 54:577-89 (2001)
DOI:10.1136/jcp.54.8.577
Reference
  Authors
Romagnani S.
  Title
The role of lymphocytes in allergic disease.
  Journal
J Allergy Clin Immunol 105:399-408 (2000)
DOI:10.1067/mai.2000.104575
Reference
  Authors
Averbeck M, Gebhardt C, Emmrich F, Treudler R, Simon JC.
  Title
Immunologic principles of allergic disease.
  Journal
J Dtsch Dermatol Ges 5:1015-28 (2007)
DOI:10.1111/j.1610-0387.2007.06538.x
Reference
  Authors
Conroy DM, Williams TJ.
  Title
Eotaxin and the attraction of eosinophils to the asthmatic lung.
  Journal
Respir Res 2:150-6 (2001)
DOI:10.1186/rr52
Reference
  Authors
Effros RM, Nagaraj H.
  Title
Asthma: new developments concerning immune mechanisms, diagnosis and treatment.
  Journal
Curr Opin Pulm Med 13:37-43 (2007)
DOI:10.1097/MCP.0b013e3280108757
Reference
  Authors
Barnes PJ.
  Title
Immunology of asthma and chronic obstructive pulmonary disease.
  Journal
Nat Rev Immunol 8:183-92 (2008)
DOI:10.1038/nri2254
Reference
  Authors
Holgate ST, Polosa R.
  Title
Treatment strategies for allergy and asthma.
  Journal
Nat Rev Immunol 8:218-30 (2008)
DOI:10.1038/nri2262
Reference
  Authors
Valenta R.
  Title
The future of antigen-specific immunotherapy of allergy.
  Journal
Nat Rev Immunol 2:446-53 (2002)
DOI:10.1038/nri824
Reference
  Authors
Trivedi SG, Lloyd CM.
  Title
Eosinophils in the pathogenesis of allergic airways disease.
  Journal
Cell Mol Life Sci 64:1269-89 (2007)
DOI:10.1007/s00018-007-6527-y
Reference
  Authors
Heinecke JW.
  Title
Eosinophil-dependent bromination in the pathogenesis of asthma.
  Journal
J Clin Invest 105:1331-2 (2000)
DOI:10.1172/JCI10072
KO pathway
ko05310   

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