KEGG   PATHWAY: mmu05320
Entry
mmu05320                    Pathway                                
Name
Autoimmune thyroid disease - Mus musculus (house mouse)
Description
The classification of autoimmune throid disease (AITD) includes Hashimoto's thyroiditis (HT) or chronic autoimmune thyroiditis and its variants, Graves' disease (GD) and autoimmune atrophic thyroiditis or primary myxedema. HT is characterized by the presence of goitre, thyroid autoantibodies against thyroid peroxidase (TPO) and thyroglobulin (Tg) in serum and varying degrees of thyroid dysfunction. During HT, self-reactive CD4+ T lymphocytes (Th) recruit B cells and CD8+ T cells (CTL) into the thyroid. Disease progression leads to the death of thyroid cells and hypothyroidism. Both autoantibodies and thyroid-specific cytotoxic T lymphocytes (CTLs) have been proposed to be responsible for autoimmune thyrocyte depletion. In GD, the TSH-R is the most important autoantigen. Antibodies directed against it mimic the effects of the hormone on thyroid cells, TSH, stimulating autonomous production of thyroxine and triiodothyronine and causing hyperthyroidism. The presence of TSH-R-blocking antibodies that bind the TSH receptor in a similar fashion to the antibodies in patients with Grave's disease but that block rather than activate the receptor explains some cases of atrophic hypothyroidism.
Class
Human Diseases; Immune disease
Pathway map
mmu05320  Autoimmune thyroid disease
mmu05320

Organism
Mus musculus (house mouse) [GN:mmu]
Gene
100504404  H2-Ea; histocompatibility 2, class II antigen E alpha [KO:K06752]
100529082  H2-T27; histocompatibility 2, T region locus 27 [KO:K06751]
110557  H2-Q6; histocompatibility 2, Q region locus 6 [KO:K06751]
110558  H2-Q9; histocompatibility 2, Q region locus 9 [KO:K06751]
110696  H2-M10.3; histocompatibility 2, M region locus 10.3 [KO:K06751]
12477  Ctla4; cytotoxic T-lymphocyte-associated protein 4 [KO:K06538]
12487  Cd28; CD28 antigen [KO:K06470]
12519  Cd80; CD80 antigen [KO:K05412]
12524  Cd86; CD86 antigen [KO:K05413]
12640  Cga; glycoprotein hormones, alpha subunit [KO:K08522]
14102  Fas; Fas cell surface death receptor [KO:K04390]
14103  Fasl; Fas ligand [KO:K04389]
14939  Gzmb; granzyme B [KO:K01353] [EC:3.4.21.79]
14960  H2-Aa; histocompatibility 2, class II antigen A, alpha [KO:K06752]
14961  H2-Ab1; histocompatibility 2, class II antigen A, beta 1 [KO:K06752]
14963  H2-Bl; histocompatibility 2, blastocyst [KO:K06751]
14964  H2-D1; histocompatibility 2, D region locus 1 [KO:K06751]
14969  H2-Eb1; histocompatibility 2, class II antigen E beta [KO:K06752]
14972  H2-K1; histocompatibility 2, K1, K region [KO:K06751]
14980  H2-L; histocompatibility 2, D region locus L [KO:K06751]
14985  H2-M10.1; histocompatibility 2, M region locus 10.1 [KO:K06751]
14990  H2-M2; histocompatibility 2, M region locus 2 [KO:K06751]
14991  H2-M3; histocompatibility 2, M region locus 3 [KO:K06751]
14997  H2-M9; histocompatibility 2, M region locus 9 [KO:K06751]
14998  H2-DMa; histocompatibility 2, class II, locus DMa [KO:K06752]
14999  H2-DMb1; histocompatibility 2, class II, locus Mb1 [KO:K06752]
15000  H2-DMb2; histocompatibility 2, class II, locus Mb2 [KO:K06752]
15001  H2-Oa; histocompatibility 2, O region alpha locus [KO:K06752]
15002  H2-Ob; histocompatibility 2, O region beta locus [KO:K06752]
15006  H2-Q1; histocompatibility 2, Q region locus 1 [KO:K06751]
15007  H2-Q10; histocompatibility 2, Q region locus 10 [KO:K06751]
15013  H2-Q2; histocompatibility 2, Q region locus 2 [KO:K06751]
15015  H2-Q4; histocompatibility 2, Q region locus 4 [KO:K06751]
15018  H2-Q7; histocompatibility 2, Q region locus 7 [KO:K06751]
15024  H2-T10; histocompatibility 2, T region locus 10 [KO:K06751]
15039  H2-T22; histocompatibility 2, T region locus 22 [KO:K06751]
15040  H2-T23; histocompatibility 2, T region locus 23 [KO:K06751]
15042  H2-T24; histocompatibility 2, T region locus 24 [KO:K06751]
15043  H2-T3; histocompatibility 2, T region locus 3 [KO:K06751]
15962  Ifna1; interferon alpha 1 [KO:K05414]
15964  Ifna11; interferon alpha 11 [KO:K05414]
15965  Ifna2; interferon alpha 2 [KO:K05414]
15967  Ifna4; interferon alpha 4 [KO:K05414]
15968  Ifna5; interferon alpha 5 [KO:K05414]
15969  Ifna6; interferon alpha 6 [KO:K05414]
15970  Ifna7; interferon alpha 7 [KO:K05414]
15972  Ifna9; interferon alpha 9 [KO:K05414]
15974  Ifnab; interferon alpha B [KO:K05414]
16153  Il10; interleukin 10 [KO:K05443]
16183  Il2; interleukin 2 [KO:K05429]
16189  Il4; interleukin 4 [KO:K05430]
16191  Il5; interleukin 5 [KO:K05428]
18646  Prf1; perforin 1 (pore forming protein) [KO:K07818]
21819  Tg; thyroglobulin [KO:K10809]
21939  Cd40; CD40 antigen [KO:K03160]
21947  Cd40lg; CD40 ligand [KO:K03161]
22018  Tpo; thyroid peroxidase [KO:K00431] [EC:1.11.1.8]
22094  Tshb; thyroid stimulating hormone, beta subunit [KO:K05251]
22095  Tshr; thyroid stimulating hormone receptor [KO:K04249]
224753  H2-M10.4; histocompatibility 2, M region locus 10.4 [KO:K06751]
224754  H2-M11; histocompatibility 2, M region locus 11 [KO:K06751]
224756  H2-M1; histocompatibility 2, M region locus 1 [KO:K06751]
224761  H2-M10.5; histocompatibility 2, M region locus 10.5 [KO:K06751]
230396  Ifna13; interferon alpha 13 [KO:K05414]
230398  Ifna16; interferon alpha 16 [KO:K05414]
240095  H2-M5; histocompatibility 2, M region locus 5 [KO:K06751]
242517  Ifna15; interferon alpha 15 [KO:K05414]
242519  Ifna12; interferon alpha 12 [KO:K05414]
333715  H2-M10.2; histocompatibility 2, M region locus 10.2 [KO:K06751]
381091  H2-Eb2; histocompatibility 2, class II antigen E beta2 [KO:K06752]
399549  H2-M10.6; histocompatibility 2, M region locus 10.6 [KO:K06751]
404549  Ifna14; interferon alpha 14 [KO:K05414]
547349  H2-K1; MHC class I family member [KO:K06751]
630294  H2-T25; histocompatibility-2, T region locus 25 [KO:K06751]
667977  H2-T26; histocompatibility 2, T region locus 26 [KO:K06751]
69717  Gm10499; predicted gene 10499 [KO:K06751]
Compound
C01382  Iodine
C01829  Thyroxine
C02465  Triiodothyronine
D00636  Amiodarone hydrochloride (JP18/USP)
Reference
PMID:15049952
  Authors
Fountoulakis S, Tsatsoulis A.
  Title
On the pathogenesis of autoimmune thyroid disease: a unifying hypothesis.
  Journal
Clin Endocrinol (Oxf) 60:397-409 (2004)
DOI:10.1046/j.1365-2265.2004.01978.x
Reference
PMID:15762980
  Authors
Chistiakov DA.
  Title
Immunogenetics of Hashimoto's thyroiditis.
  Journal
J Autoimmune Dis 2:1 (2005)
DOI:10.1186/1740-2557-2-1
Reference
PMID:9534029
  Authors
McIver B, Morris JC.
  Title
The pathogenesis of Graves' disease.
  Journal
Endocrinol Metab Clin North Am 27:73-89 (1998)
DOI:10.1016/S0889-8529(05)70299-1
Reference
PMID:11913070
  Authors
Stassi G, De Maria R.
  Title
Autoimmune thyroid disease: new models of cell death in autoimmunity.
  Journal
Nat Rev Immunol 2:195-204 (2002)
DOI:10.1038/nri750
Reference
PMID:12192541
  Authors
Collins J, Gough S.
  Title
Autoimmunity in thyroid disease.
  Journal
Eur J Nucl Med Mol Imaging 29 Suppl 2:S417-24 (2002)
DOI:10.1007/s00259-002-0848-8
Reference
PMID:11396701
  Authors
Ruwhof C, Drexhage HA.
  Title
Iodine and thyroid autoimmune disease in animal models.
  Journal
Thyroid 11:427-36 (2001)
DOI:10.1089/105072501300176381
Reference
PMID:17192582
  Authors
Tsatsoulis A.
  Title
The role of stress in the clinical expression of thyroid autoimmunity.
  Journal
Ann N Y Acad Sci 1088:382-95 (2006)
DOI:10.1196/annals.1366.015
Reference
PMID:15132715
  Authors
Prummel MF, Strieder T, Wiersinga WM.
  Title
The environment and autoimmune thyroid diseases.
  Journal
Eur J Endocrinol 150:605-18 (2004)
DOI:10.1530/eje.0.1500605
Reference
PMID:11577986
  Authors
Kopp P.
  Title
The TSH receptor and its role in thyroid disease.
  Journal
Cell Mol Life Sci 58:1301-22 (2001)
DOI:10.1007/PL00000941
Related
pathway
mmu04210  Apoptosis
mmu04514  Cell adhesion molecules
mmu04610  Complement and coagulation cascades
mmu04612  Antigen processing and presentation
mmu04660  T cell receptor signaling pathway
mmu04662  B cell receptor signaling pathway
mmu04918  Thyroid hormone synthesis
KO pathway
ko05320   

  All links  
No link information was found.
DBGET integrated database retrieval system