KEGG   PATHWAY: ncr03440Help
Entry
ncr03440                    Pathway                                

Name
Homologous recombination - Neurospora crassa
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
ncr03440  Homologous recombination
ncr03440

Ortholog table
Module
ncr_M00288  RPA complex [PATH:ncr03440]
Other DBs
BSID: 87567
GO: 0000724
Organism
Neurospora crassa [GN:ncr]
Gene
NCU00901  uvs-6; ultraviolet-sensitive-6 [KO:K10866] [EC:3.6.-.-]
NCU08730  mus-23; mutagen sensitive-23 [KO:K10865]
NCU00274  mus-21; mutagen sensitive-21 [KO:K04728] [EC:2.7.11.1]
NCU07913  hypothetical protein [KO:K10881]
NCU01771  DNA repair protein rhp57 [KO:K10958]
NCU03606  rpa-1; replication protein A-1 [KO:K07466]
NCU07717  rpa-2; replication protein A-2 [KO:K10739]
NCU01460  rpa-3; replication protein A-3 [KO:K10740]
NCU02741  mei-3; meiotic-3 [KO:K04482]
NCU04275  mus-11; mutagen sensitive-11 [KO:K10873]
NCU02348  mus-25; mutagen sensitive-25 [KO:K10875] [EC:3.6.4.-]
NCU01192  pold-1; DNA polymerase Delta-1 [KO:K02327] [EC:2.7.7.7]
NCU03763  DNA polymerase delta subunit 2 [KO:K02328]
NCU07998  hypothetical protein [KO:K03504]
NCU03528  DNA polymerase delta subunit 4 [KO:K03505]
NCU08598  qde-3; quelling-defective-3 [KO:K10901] [EC:3.6.4.12]
NCU00081  DNA topoisomerase 3-beta [KO:K03165] [EC:5.99.1.2]
NCU07457  crossover junction endonuclease mus-81 [KO:K08991] [EC:3.1.22.-]
NCU06826  hypothetical protein [KO:K10882] [EC:3.1.22.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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