KEGG   PATHWAY: ndi03440Help
Entry
ndi03440                    Pathway                                

Name
Homologous recombination - Naumovozyma dairenensis
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
ndi03440  Homologous recombination
ndi03440

Ortholog table
Module
ndi_M00292  MRX complex [PATH:ndi03440]
Other DBs
BSID: 701364
GO: 0000724
Organism
Naumovozyma dairenensis [GN:ndi]
Gene
NDAI_0F04000  NDAI0F04000; hypothetical protein [KO:K10866] [EC:3.6.-.-]
NDAI_0K00980  NDAI0K00980; hypothetical protein [KO:K10865]
NDAI_0B05680  NDAI0B05680; hypothetical protein [KO:K10868]
NDAI_0E04020  NDAI0E04020; hypothetical protein [KO:K04728] [EC:2.7.11.1]
NDAI_0B05610  NDAI0B05610; hypothetical protein [KO:K10881]
NDAI_0A03620  NDAI0A03620; hypothetical protein [KO:K10957]
NDAI_0A06550  NDAI0A06550; hypothetical protein [KO:K10958]
NDAI_0J01860  NDAI0J01860; hypothetical protein [KO:K07466]
NDAI_0G03880  NDAI0G03880; hypothetical protein [KO:K10739]
NDAI_0A01680  NDAI0A01680; hypothetical protein [KO:K04482]
NDAI_0C00800  NDAI0C00800; hypothetical protein [KO:K10873]
NDAI_0D04410  NDAI0D04410; hypothetical protein [KO:K10959]
NDAI_0K02510  NDAI0K02510; hypothetical protein [KO:K10875] [EC:3.6.4.-]
NDAI_0A07510  NDAI0A07510; hypothetical protein [KO:K10877] [EC:3.6.4.-]
NDAI_0B03180  NDAI0B03180; hypothetical protein [KO:K02327] [EC:2.7.7.7]
NDAI_0C02800  NDAI0C02800; hypothetical protein [KO:K02328]
NDAI_0G04780  NDAI0G04780; hypothetical protein [KO:K03504]
NDAI_0I00750  NDAI0I00750; hypothetical protein [KO:K10901] [EC:3.6.4.12]
NDAI_0F01230  NDAI0F01230; hypothetical protein [KO:K10901] [EC:3.6.4.12]
NDAI_0G02110  NDAI0G02110; hypothetical protein [KO:K03165] [EC:5.99.1.2]
NDAI_0A04370  NDAI0A04370; hypothetical protein [KO:K08991] [EC:3.1.22.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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