KEGG   PATHWAY: ngi05330
Entry
ngi05330                    Pathway                                

Name
Allograft rejection - Nannospalax galili (Upper Galilee mountains blind mole rat)
Description
Allograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of antigen presentation. In the direct pathway, recipient T cells react to intact allogeneic MHC molecules expressed on the surface of donor cells. This pathway would activate host CD4 or CD8 T cells. In contrast, donor MHC molecules (and all other proteins) shed from the graft can be taken up by host APCs and presented to recipient T cells in the context of self-MHC molecules - the indirect pathway. Such presentation activates predominantly CD4 T cells. A direct cytotoxic T-cell attack on graft cells can be made only by T cells that recognize the graft MHC molecules directly. Nontheless, T cells with indirect allospecificity can contribute to graft rejection by activating macrophages, which cause tissue injury and fibrosis, and are also likely to be important in the development of an alloantibody response to graft.
Class
Human Diseases; Immune disease
Pathway map
ngi05330  Allograft rejection
ngi05330

Organism
Nannospalax galili (Upper Galilee mountains blind mole rat) [GN:ngi]
Gene
103738688  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
103740578  class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like [KO:K06751]
103739356  HLA class I histocompatibility antigen, B-73 alpha chain-like [KO:K06751]
103744250  HLA class I histocompatibility antigen, A-30 alpha chain-like [KO:K06751]
103747894  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
103725555  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
103752329  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
103752528  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
103752527  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
103724463  patr class I histocompatibility antigen, A-126 alpha chain [KO:K06751]
103731142  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
103729790  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
103729781  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
103729792  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
103729784  HLA class I histocompatibility antigen, A-23 alpha chain-like [KO:K06751]
103729783  class I histocompatibility antigen, B alpha chain-like [KO:K06751]
103742022  Cd80; CD80 molecule [KO:K05412]
103742023  T-lymphocyte activation antigen CD80-like [KO:K05412]
103741969  Cd86; CD86 molecule [KO:K05413]
103744474  Cd28; CD28 molecule [KO:K06470]
103745345  Il12a; interleukin 12A [KO:K05406]
103724546  Il12b; interleukin 12B [KO:K05425]
103740694  Faslg; Fas ligand [KO:K04389]
103738053  Fas; Fas cell surface death receptor [KO:K04390]
103736978  Prf1; perforin 1 [KO:K07818]
103739490  granzyme B-like [KO:K01353] [EC:3.4.21.79]
103744106  granzyme B-like [KO:K01353] [EC:3.4.21.79]
103751171  granzyme B-like [KO:K01353] [EC:3.4.21.79]
103732523  granzyme B-like [KO:K01353] [EC:3.4.21.79]
103748403  SMH class II histocompatibility antigen, beta-1 chain-like [KO:K06752]
103747627  SMH class II histocompatibility antigen, beta-1 chain [KO:K06752]
103747703  HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
103748487  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
103747994  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
103748078  class II histocompatibility antigen, M beta 1 chain [KO:K06752]
103747550  HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
103729174  rano class II histocompatibility antigen, B-1 beta chain-like [KO:K06752]
103729166  H-2 class II histocompatibility antigen, A-F alpha chain-like [KO:K06752]
103729147  rano class II histocompatibility antigen, B alpha chain [KO:K06752]
103729158  rano class II histocompatibility antigen, A beta chain-like [KO:K06752]
103738064  rano class II histocompatibility antigen, B-1 beta chain [KO:K06752]
103739735  SMH class II histocompatibility antigen, beta-1 chain-like [KO:K06752]
103745139  HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
103745137  RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752]
103741891  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
103741892  HLA class II histocompatibility antigen, DRB1-1 beta chain-like [KO:K06752]
103741888  HLA class II histocompatibility antigen, DR beta 4 chain-like [KO:K06752]
103724457  HLA class II histocompatibility antigen, DRB1-10 beta chain-like [KO:K06752]
103725871  patr class II histocompatibility antigen, DO beta chain-like [KO:K06752]
103731003  rano class II histocompatibility antigen, A beta chain-like [KO:K06752]
103731002  SLA class II histocompatibility antigen, DQ haplotype D alpha chain [KO:K06752]
103746951  Il2; interleukin 2 [KO:K05429]
103740147  Cd40lg; CD40 ligand [KO:K03161]
103751235  Cd40; CD40 molecule [KO:K03160]
103745085  Ifng; interferon gamma [KO:K04687]
103724452  Tnf; tumor necrosis factor [KO:K03156]
103747047  Il4; interleukin 4 [KO:K05430]
103747045  Il5; interleukin 5 [KO:K05428]
103725974  Il10; interleukin 10 [KO:K05443]
103751925  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
103726091  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
Compound
C00533  Nitric oxide
Reference
  Authors
Arakelov A, Lakkis FG.
  Title
The alloimmune response and effector mechanisms of allograft rejection.
  Journal
Semin Nephrol 20:95-102 (2000)
Reference
  Authors
Le Moine A, Goldman M, Abramowicz D.
  Title
Multiple pathways to allograft rejection.
  Journal
Transplantation 73:1373-81 (2002)
DOI:10.1097/00007890-200205150-00001
Reference
  Authors
Trivedi HL.
  Title
Immunobiology of rejection and adaptation.
  Journal
Transplant Proc 39:647-52 (2007)
DOI:10.1016/j.transproceed.2007.01.047
Reference
  Authors
Pietra BA.
  Title
Transplantation immunology 2003: simplified approach.
  Journal
Pediatr Clin North Am 50:1233-59 (2003)
DOI:10.1016/S0031-3955(03)00119-6
Reference
PMID:8835634
  Authors
Oka T, Yoshimura N.
  Title
Immunosuppression in organ transplantation.
  Journal
Jpn J Pharmacol 71:89-100 (1996)
DOI:10.1254/jjp.71.89
Reference
  Authors
Sayegh MH.
  Title
Why do we reject a graft? Role of indirect allorecognition in graft rejection.
  Journal
Kidney Int 56:1967-79 (1999)
DOI:10.1046/j.1523-1755.1999.00751.x
Reference
  Authors
Benichou G.
  Title
Direct and indirect antigen recognition: the pathways to allograft immune rejection.
  Journal
Front Biosci 4:D476-80 (1999)
DOI:10.2741/benichou
Reference
  Authors
Turvey SE, Wood KJ.
  Title
Immunobiology of solid organ transplantation.
  Journal
Int Surg 84:279-90 (1999)
Reference
  Authors
Janeway CA, Travers P, Walport M, Shlomchik MJ.
  Title
Immunobiology 6th edition
  Journal
Garland Science Publishing (2005)
Reference
  Authors
Game DS, Lechler RI.
  Title
Pathways of allorecognition: implications for transplantation tolerance.
  Journal
Transpl Immunol 10:101-8 (2002)
DOI:10.1016/S0966-3274(02)00055-2
Reference
  Authors
Lechler RI, Garden OA, Turka LA.
  Title
The complementary roles of deletion and regulation in transplantation tolerance.
  Journal
Nat Rev Immunol 3:147-58 (2003)
DOI:10.1038/nri1002
Related
pathway
ngi04210  Apoptosis
ngi04514  Cell adhesion molecules
ngi04610  Complement and coagulation cascades
ngi04612  Antigen processing and presentation
ngi04660  T cell receptor signaling pathway
ngi04662  B cell receptor signaling pathway
KO pathway
ko05330   

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