KEGG   PATHWAY: nmi03440Help
Entry
nmi03440                    Pathway                                

Name
Homologous recombination - Neisseria meningitidis alpha14 (cnl strain)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
nmi03440  Homologous recombination
nmi03440

Ortholog table
Module
nmi_M00260  DNA polymerase III complex, bacteria [PATH:nmi03440]
Other DBs
BSID: 117810
GO: 0000724
Organism
Neisseria meningitidis alpha14 (cnl strain) [GN:nmi]
Gene
NMO_0725  recJ; single-stranded-DNA-specific exonuclease [KO:K07462] [EC:3.1.-.-]
NMO_1292  ssb; single-strand binding protein [KO:K03111]
NMO_1594  recO; DNA repair protein RecO [KO:K03584]
NMO_1050  recR; recombination protein RecR [KO:K06187]
NMO_1278  recA; RecA protein [KO:K03553]
NMO_0191  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
NMO_1772  ruvA; holliday junction DNA helicase [KO:K03550] [EC:3.6.4.12]
NMO_1056  ruvB; holliday junction DNA helicase [KO:K03551] [EC:3.6.4.12]
NMO_1252  ruvC; crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.22.4]
NMO_0388  recG; ATP-dependent DNA helicase [KO:K03655] [EC:3.6.4.12]
NMO_0673  recB; exodeoxyribonuclease V, beta subunit [KO:K03582] [EC:3.1.11.5]
NMO_1536  recC; exodeoxyribonuclease V gamma chain [KO:K03583] [EC:3.1.11.5]
NMO_1045  recD; exodeoxyribonuclease V, alpha subunit [KO:K03581] [EC:3.1.11.5]
NMO_0349  dnaE; DNA polymerase III alpha subunit [KO:K02337] [EC:2.7.7.7]
NMO_0268  dnaN; DNA polymerase III, beta chain [KO:K02338] [EC:2.7.7.7]
NMO_1276  dnaZX; putative DNA polymerase III tau and gamma chain [KO:K02343] [EC:2.7.7.7]
NMO_0599  holA; putative DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
NMO_0658  holB; DNA polymerase III, delta' subunit [KO:K02341] [EC:2.7.7.7]
NMO_1335  dnaQ; DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
NMO_1285  putative DNA polymerase III subunit [KO:K02342] [EC:2.7.7.7]
NMO_1379  holC; DNA polymerase III chi subunit [KO:K02339] [EC:2.7.7.7]
NMO_0433  priA; putative primosomal protein [KO:K04066] [EC:3.6.4.-]
NMO_1162  priB; primosomal replication protein [KO:K02686]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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