KEGG   PATHWAY: pae02010
Entry
pae02010                    Pathway                                
Name
ABC transporters - Pseudomonas aeruginosa PAO1
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
pae02010  ABC transporters
pae02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Pseudomonas aeruginosa PAO1 [GN:pae]
Gene
PA1493  cysP; sulfate ABC transporter substrate-binding protein [KO:K02048]
PA0283  sbp; sulfate-binding protein [KO:K23163]
PA0282  cysT; sulfate transporter CysT [KO:K02046]
PA0281  cysW; sulfate transporter CysW [KO:K02047]
PA0280  cysA; sulfate.thiosulfate ABC transporter ATP-binding protein CysA [KO:K02045] [EC:7.3.2.3]
PA3938  taurine-binding protein [KO:K15551]
PA3936  taurine ABC transporter permease [KO:K15552]
PA3937  taurine ABC transporter ATP-binding protein [KO:K10831] [EC:7.6.2.7]
PA3449  hypothetical protein [KO:K15553]
PA2595  hypothetical protein [KO:K15553]
PA2594  hypothetical protein [KO:K15553]
PA3445  hypothetical protein [KO:K15553]
PA0186  ABC transporter [KO:K15553]
PA2596  hypothetical protein [KO:K15553]
PA2599  hypothetical protein [KO:K15553]
PA2309  hypothetical protein [KO:K15553]
PA2296  hypothetical protein [KO:K15553]
PA3443  ABC transporter permease [KO:K15554]
PA3448  ABC transporter permease [KO:K15554]
PA0185  ABC transporter permease [KO:K15554]
PA2307  ABC transporter permease [KO:K15554]
PA2295  ABC transporter permease [KO:K15554]
PA3442  aliphatic sulfonates ABC transporter ATP-binding subunit [KO:K15555] [EC:7.6.2.14]
PA0184  ABC transporter ATP-binding protein [KO:K15555] [EC:7.6.2.14]
PA3447  ABC transporter ATP-binding protein [KO:K15555] [EC:7.6.2.14]
PA2308  ABC transporter ATP-binding protein [KO:K15555] [EC:7.6.2.14]
PA2294  ABC transporter ATP-binding protein [KO:K15555] [EC:7.6.2.14]
PA1863  modA; molybdenum ABC transporter substrate-binding protein ModA [KO:K02020]
PA1862  modB; molybdenum ABC transporter permease ModB [KO:K02018]
PA1861  modC; molybdenum ABC transporter ATP-binding protein ModC [KO:K02017] [EC:7.3.2.5]
PA5217  iron ABC transporter substrate-binding protein [KO:K02012]
PA4687  hitA; ferric iron-binding periplasmic protein HitA [KO:K02012]
PA5216  iron ABC transporter substrate-binding protein [KO:K02011]
PA4688  hitB; iron (III)-transporter permease HitB [KO:K02011]
PA3538  ABC transporter ATP-binding protein [KO:K02010] [EC:7.2.2.7]
PA3610  potD; polyamine ABC transporter substrate-binding protein PotD [KO:K11069]
PA0323  ABC transporter [KO:K11069]
PA0203  ABC transporter [KO:K11069]
PA3609  potC; polyamine ABC transporter permease PotC [KO:K11070]
PA0324  ABC transporter permease [KO:K11070]
PA0204  ABC transporter permease [KO:K11070]
PA3608  potB; polyamine ABC transporter permease PotB [KO:K11071]
PA0325  ABC transporter permease [KO:K11071]
PA0205  ABC transporter permease [KO:K11071]
PA3607  potA; polyamine transporter ATP-binding protein PotA [KO:K11072] [EC:7.6.2.11]
PA0206  spermidine/putrescine ABC transporter ATP-binding protein [KO:K11072] [EC:7.6.2.11]
PA0326  ABC transporter ATP-binding protein [KO:K11072] [EC:7.6.2.11]
PA0300  spuD; putrescine ABC transporter substrate-binding protein SpuD [KO:K11073]
PA0301  spuE; spermidine ABC transporter substrate-binding protein SpuE [KO:K11073]
PA1410  spermidine/putrescine-binding protein [KO:K11073]
PA2711  spermidine/putrescine-binding protein [KO:K11073]
PA2592  spermidine/putrescine-binding protein [KO:K11073]
PA0295  polyamine binding protein [KO:K11073]
PA0304  spuH; polyamine transporter PotI [KO:K11074]
PA0303  spuG; polyamine transporter PotH [KO:K11075]
PA0302  spuF; polyamine transporter PotG [KO:K11076] [EC:7.6.2.16]
PA5096  ABC transporter [KO:K02002]
PA0030  hypothetical protein [KO:K02002]
PA5103  hypothetical protein [KO:K02002]
PA5378  hypothetical protein [KO:K02002]
PA5388  hypothetical protein [KO:K02002]
PA3236  glycine betaine-binding protein [KO:K02002]
PA5095  ABC transporter permease [KO:K02001]
PA5377  ABC transporter permease [KO:K02001]
PA5094  ABC transporter ATP-binding protein [KO:K02000] [EC:7.6.2.9]
PA5376  ABC transporter ATP-binding protein [KO:K02000] [EC:7.6.2.9]
PA3889  ABC transporter [KO:K05845]
PA3890  ABC transporter permease [KO:K05846]
PA3888  ABC transporter permease [KO:K05846]
PA3891  ABC transporter ATP-binding protein [KO:K05847] [EC:7.6.2.9]
PA2341  maltose ABC transporter ATP-binding protein [KO:K10111] [EC:7.5.2.-]
PA3187  ABC transporter ATP-binding protein [KO:K10112] [EC:7.5.2.-]
PA2338  maltose/mannitol ABC transporter substrate-binding protein [KO:K10227]
PA2339  binding-protein-dependent maltose/mannitol transport protein [KO:K10228]
PA2340  binding-protein-dependent maltose/mannitol transport protein [KO:K10229]
PA4453  hypothetical protein [KO:K07323]
PA4454  hypothetical protein [KO:K02067]
PA3213  hypothetical protein [KO:K02067]
PA4455  ABC transporter permease [KO:K02066]
PA3211  ABC transporter permease [KO:K02066]
PA4452  hypothetical protein [KO:K07122]
PA4456  ABC transporter ATP-binding protein [KO:K02065]
PA3212  ABC transporter ATP-binding protein [KO:K02065]
PA0146  hypothetical protein [KO:K07335]
PA0137  ABC transporter permease [KO:K23535]
PA0138  ABC transporter permease [KO:K23536]
PA0136  ABC transporter ATP-binding protein [KO:K23537]
PA3190  sugar ABC transporter substrate-binding protein [KO:K17315]
PA3189  sugar ABC transporter permease [KO:K17316]
PA3188  sugar ABC transporter permease [KO:K17317]
PA1946  rbsB; ribose ABC transporter substrate-binding protein [KO:K10439]
PA1948  rbsC; ribose ABC transporter permease [KO:K10440]
PA1947  rbsA; ribose transporter RbsA [KO:K10441] [EC:7.5.2.7]
PA2548  hypothetical protein [KO:K02040]
PA5369  pstS; phosphate ABC transporter substrate-binding protein [KO:K02040]
PA5368  pstC; phosphate ABC transporter permease [KO:K02037]
PA5367  pstA; phosphate ABC transporter permease [KO:K02038]
PA5366  pstB; phosphate ABC transporter ATP-binding protein [KO:K02036] [EC:7.3.2.1]
PA3313  hypothetical protein [KO:K02044]
PA3383  phosphonate ABC transporter substrate-binding protein [KO:K02044]
PA3315  phosphonates ABC transporter permease [KO:K02042]
PA3316  ABC transporter permease [KO:K02042]
PA3382  phnE; phosphonate transporter PhnE [KO:K02042]
PA3314  phosphonates ABC transporter ATP-binding protein [KO:K02041] [EC:7.3.2.2]
PA3384  phnC; phosphonate ABC transporter ATP-binding protein [KO:K02041] [EC:7.3.2.2]
PA2925  hisM; histidine ABC transporter permease HisM [KO:K10015]
PA2924  hisQ; histidine ABC transporter permease HisQ [KO:K10016]
PA2926  hisP; histidine ABC transporter ATP-binding protein HisP [KO:K10017] [EC:7.4.2.1]
PA2923  hisJ; histidine ABC transporter substrate-binding protein HisJ [KO:K10014]
PA1342  ABC transporter [KO:K10001]
PA1340  amino acid ABC transporter permease [KO:K10002]
PA1341  amino acid ABC transporter permease [KO:K10003]
PA1339  amino acid ABC transporter ATP binding protein [KO:K10004] [EC:7.4.2.1]
PA3858  amino acid-binding protein [KO:K09969]
PA0314  L-cysteine ABC transporter protein FliY [KO:K02424]
PA0313  L-cysteine ABC transporter protein YecS [KO:K10009]
PA0888  aotJ; arginine/ornithine ABC transporter substrate-binding protein AotJ [KO:K10022]
PA3865  amino acid binding protein [KO:K10022]
PA0890  aotM; arginine/ornithine ABC transporter permease AotM [KO:K10023]
PA0889  aotQ; arginine/ornithine ABC transporter permease AotQ [KO:K10024]
PA0892  aotP; arginine/ornithine ABC transporter ATP-binding protein AotP [KO:K10025] [EC:7.4.2.1]
PA5153  amino acid ABC transporter substrate-binding protein [KO:K23055]
PA5154  ABC transporter permease [KO:K23056]
PA5155  amino acid ABC transporter permease [KO:K23057]
PA5152  ABC transporter ATP-binding protein [KO:K23058] [EC:7.4.2.1]
PA1260  amino acid ABC transporter substrate-binding protein [KO:K23061]
PA1258  ABC transporter permease [KO:K23062]
PA1257  amino acid ABC transporter permease [KO:K23063]
PA1256  amino acid ABC transporter ATP binding protein [KO:K23064] [EC:7.4.2.1]
PA1074  braC; branched-chain amino acid ABC transporter substrate-binding protein BraC [KO:K01999]
PA4913  ABC transporter [KO:K01999]
PA3364  amiC; aliphatic amidase expression-regulating protein [KO:K01999]
PA1073  braD; branched-chain amino acid ABC transporter permease BraD [KO:K01997]
PA4912  branched-chain amino acid ABC transporter [KO:K01997]
PA1072  braE; branched-chain amino acid ABC transporter permease BraE [KO:K01998]
PA4911  branched-chain amino acid ABC transporter permease [KO:K01998]
PA1071  braF; ABC transporter ATP-binding protein [KO:K01995]
PA4910  ABC transporter ATP-binding protein [KO:K01995]
PA1070  braG; ABC transporter ATP-binding protein [KO:K01996]
PA4909  ABC transporter ATP-binding protein [KO:K01996]
PA5505  TonB-dependent receptor [KO:K02073]
PA3931  hypothetical protein [KO:K02073]
PA2349  hypothetical protein [KO:K02073]
PA2351  ABC transporter permease [KO:K02072]
PA5504  D-methionine ABC transporter [KO:K02072]
PA5503  ABC transporter ATP-binding protein [KO:K02071]
PA2350  methionine ABC transporter ATP-binding protein [KO:K02071]
PA4858  hypothetical protein [KO:K11959]
PA4859  ABC transporter permease [KO:K11960]
PA4860  ABC transporter permease [KO:K11961]
PA4861  ABC transporter ATP-binding protein [KO:K11962]
PA4862  ABC transporter ATP-binding protein [KO:K11963]
PA4496  ABC transporter [KO:K12368]
PA4500  ABC transporter [KO:K12368]
PA4502  ABC transporter [KO:K12368]
PA5317  dipeptide ABC transporter substrate-binding protein [KO:K12368]
PA4497  ABC transporter [KO:K12368]
PA4503  ABC transporter permease [KO:K12369]
PA4504  ABC transporter permease [KO:K12370]
PA4505  ABC transporter ATP-binding protein [KO:K12371]
PA4506  peptide ABC transporter ATP-binding protein [KO:K12372]
PA2058  ABC transporter [KO:K13893]
PA1810  ABC transporter [KO:K13893]
PA1811  solute-binding protein [KO:K13893]
PA2059  ABC transporter permease [KO:K13894]
PA1809  ABC transporter permease [KO:K13894]
PA1808  ABC transporter permease [KO:K13895]
PA2060  ABC transporter permease [KO:K13895]
PA2061  ABC transporter ATP-binding protein [KO:K13896]
PA1807  ABC transporter ATP-binding protein [KO:K13896]
PA4159  fepB; iron-enterobactin transporter periplasmic binding protein [KO:K23185]
PA4160  fepD; ferric enterobactin transporter FepD [KO:K23186]
PA4161  fepG; ferric enterobactin transporter FepG [KO:K23187]
PA4158  fepC; ferric enterobactin transporter FepC [KO:K23188] [EC:7.2.2.17 7.2.2.-]
PA4045  hypothetical protein [KO:K06858]
PA2407  adhesion protein [KO:K09815]
PA5498  adhesin [KO:K09815]
PA2409  ABC transporter permease [KO:K09816]
PA5501  znuB; zinc ABC transporter permease [KO:K09816]
PA2408  ABC transporter ATP-binding protein [KO:K09817] [EC:7.2.2.20]
PA5500  znuC; zinc transporter ZnuC [KO:K09817] [EC:7.2.2.20]
PA5451  wzm; LPS efflux transporter membrane protein [KO:K09690]
PA2678  ABC transporter permease [KO:K09690]
PA5450  wzt; ABC transporter [KO:K09691] [EC:7.5.2.14]
PA1386  ABC transporter ATP-binding protein [KO:K09691] [EC:7.5.2.14]
PA2986  hypothetical protein [KO:K09808]
PA2988  hypothetical protein [KO:K09808]
PA2987  lipoprotein-releasing system ABC transporter ATP-binding protein [KO:K09810] [EC:7.6.2.-]
PA1478  heme exporter protein CcmD [KO:K02196]
PA1477  ccmC; heme exporter protein CcmC [KO:K02195]
PA1476  ccmB; heme exporter protein CcmB [KO:K02194]
PA1475  ccmA; cytochrome c biogenesis ATP-binding export protein CcmA [KO:K02193] [EC:7.6.2.5]
PA3828  hypothetical protein [KO:K07091]
PA3827  hypothetical protein [KO:K11720]
PA4461  ABC transporter ATP-binding protein [KO:K06861] [EC:7.5.2.5]
PA3395  nosY; membrane protein NosY [KO:K19341]
PA3394  nosF; copper ABC transporter ATP-binding protein [KO:K19340]
PA0375  ftsX; cell division protein FtsX [KO:K09811]
PA0374  ftsE; cell division protein FtsE [KO:K09812]
PA4997  msbA; transporter MsbA [KO:K11085] [EC:7.5.2.6]
PA4143  toxin transporter [KO:K13409]
PA3228  ABC transporter ATP-binding protein/permease [KO:K18893]
PA1876  ABC transporter ATP-binding protein/permease [KO:K12541]
PA3406  hasD; transporter HasD [KO:K12536]
PA1246  aprD; alkaline protease secretion ATP-binding protein AprD [KO:K12536]
PA2390  pvdT; pyoverdine biosynthesis protein PvdT [KO:K05685] [EC:7.6.2.-]
PA2397  pvdE; pyoverdine biosynthesis protein PvdE [KO:K06160]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   

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Genome (1)   
   KEGG GENOME (1)   
Gene (207)   
   KEGG GENES (207)   
All databases (208)   

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