KEGG   PATHWAY: pag00290
Entry
pag00290                    Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Pseudomonas aeruginosa LESB58
Class
Metabolism; Amino acid metabolism
Pathway map
pag00290  Valine, leucine and isoleucine biosynthesis
pag00290

Module
pag_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:pag00290]
pag_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:pag00290]
pag_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:pag00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Pseudomonas aeruginosa LESB58 [GN:pag]
Gene
PLES_44671  hypothetical [KO:K01754] [EC:4.3.1.19]
PLES_03281  ilvA1; threonine dehydratase, biosynthetic [KO:K01754] [EC:4.3.1.19]
PLES_38551  ilvA2; threonine dehydratase, biosynthetic [KO:K01754] [EC:4.3.1.19]
PLES_19381  leuC; 3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
PLES_19391  leuD; 3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
PLES_19411  leuB; 3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
PLES_32871  probable decarboxylase [KO:K01652] [EC:2.2.1.6]
PLES_50811  ilvI; acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
PLES_07471  probable acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
PLES_39961  probable decarboxylase [KO:K01652] [EC:2.2.1.6]
PLES_50801  ilvH; acetolactate synthase isozyme III small subunit [KO:K01653] [EC:2.2.1.6]
PLES_50791  ilvC; ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
PLES_03501  ilvD; dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
PLES_54021  ilvE; branched-chain amino acid transferase [KO:K00826] [EC:2.6.1.42]
PLES_16421  ldh; leucine dehydrogenase [KO:K00263] [EC:1.4.1.9]
PLES_22371  probable aminotransferase [KO:K14260] [EC:2.6.1.66 2.6.1.2]
PLES_11821  leuA; 2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
PLES_40921  probable 2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
PMID:15292141
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
pag00260  Glycine, serine and threonine metabolism
pag00280  Valine, leucine and isoleucine degradation
pag00620  Pyruvate metabolism
KO pathway
ko00290   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG GENES (18)   
All databases (19)   

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