KEGG   PATHWAY: pay02060
Entry
pay02060                    Pathway                                
Name
Phosphotransferase system (PTS) - Photorhabdus asymbiotica
Description
The phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) is a major mechanism used by bacteria for uptake of carbohydrates, particularly hexoses, hexitols, and disaccharides, where the source of energy is from PEP. The PTS consists of two general components, enzyme I (EI) and histidine phosphocarrier protein (HPr), and of membrane-bound sugar specific permeases (enzymes II). Each enzyme II (EII) complex consists of one or two hydrophobic integral membrane domains (domains C and D) and two hydrophilic domains (domains A and B). EII complexes may exist as distinct proteins or as a single multidomain protein. The PTS catalyzes the uptake of carbohydrates and their conversion into their respective phosphoesters during transport. There are four successive phosphoryl transfers in the PTS. Initial autophosphorylation of EI, using PEP as a substrate, is followed by transfer of the phosphoryl group from EI to HPr. EIIA catalyzes the self-phosphoryl transfer from HPr after which the phosphoryl group is transferred to histidine or cysteine residues of EIIB. The sugar is transported through the membrane-bound EIIC and is phosphorylated by the appropriate sugar-specific EIIB.
Class
Environmental Information Processing; Membrane transport
Pathway map
pay02060  Phosphotransferase system (PTS)
pay02060

Other DBs
GO: 0009401
TC: 4.A
Organism
Photorhabdus asymbiotica [GN:pay]
Gene
PAU_01403  ptsI; phosphoenolpyruvate-protein phosphotransferase (phosphotransferas system, enzyme i) [KO:K08483] [EC:2.7.3.9]
PAU_01404  ptsH; phosphocarrier protein hpr (histidine-containing protein) [KO:K02784]
PAU_01402  crr; glucose-specific phosphotransferase enzyme IIA component [KO:K02777] [EC:2.7.1.-]
PAU_03088  nagE; pts system, n-acetylglucosamine-specific iiabc component [KO:K02804] [EC:2.7.1.193]
PAU_01260  scrA; PTS system, sucrose-specific IIBC [KO:K02810] [EC:2.7.1.211]
PAU_00547  bglF; beta-glucoside-specific phosphotransferase system-dependent permease [KO:K02757] [EC:2.7.1.-]
PAU_00549  bglP; similar to beta-glucoside permease iiabc component [KO:K02757] [EC:2.7.1.-]
PAU_01357  treB; pts system, trehalose-specific iibc component (eiibc-tre) (trehalose permease iibc component) (phosphotransferase enzyme ii, bc component (eii-tre) [KO:K02819] [EC:2.7.1.201]
PAU_00314  putative PTS system EIIBC component [KO:K11192] [EC:2.7.1.192]
PAU_01786  celC; pts system, cellobiose-specific iia component (eiia-cel) (cellobiose permease iia component) (phosphotransferase enzyme ii, a component (eiii-cel) [KO:K02759] [EC:2.7.1.196 2.7.1.205]
PAU_01788  celA; pts system, cellobiose-specific iib component [KO:K02760] [EC:2.7.1.196 2.7.1.205]
PAU_01787  celB; phosphotransferase system cellobiose-specific component iic [KO:K02761]
PAU_01837  manX; pts system, mannose-specific iiab component (eiiab-man) (mannose permease iiab component) (phosphotransferase enzyme ii, ab component (eiii-man) [KO:K02794] [EC:2.7.1.191]
PAU_01836  manY; pts system, mannose-specific iic component (eiic-man) (mannose permease iic component) (phosphotransferase enzyme ii, c component (eii-p-man) [KO:K02795]
PAU_01835  manZ; pts system, mannose-specific iid component (eiid-man) (mannose permease iid component) (phosphotransferase enzyme ii, d component (eii-m-man) [KO:K02796]
PAU_00778  yadI; similar to putative pts system iia component yadi of escherichia coli [KO:K02744] [EC:2.7.1.-]
PAU_00775  agaV; pts system, n-acetylgalactosamine-specific iib component 2 (eiib-aga' (n-acetylgalactosamine-permease iib component 2) (phosphotransferas enzyme ii, b component 2) [KO:K02745] [EC:2.7.1.-]
PAU_00776  agaC; pts system, n-acetylgalactosamine-specific iic component 1 (eiic-aga (n-acetylgalactosamine-permease iic component 1) [KO:K02746]
PAU_00777  agaD; pts system, n-acetylgalactosamine-specific iid component (eiid-aga (n-acetylgalactosamine-permease iid component) (phosphotransferas enzyme ii, d component) [KO:K02747]
PAU_02591  sgcA; putative phosphotransferase enzyme ii, a component sgca [KO:K02821] [EC:2.7.1.194]
PAU_02590  sgaB; conserved hypothetical protein [KO:K02822] [EC:2.7.1.194]
PAU_02589  conserved hypothetical protein [KO:K03475]
PAU_01678  fruK; 1-phosphofructokinase [KO:K00882] [EC:2.7.1.56]
PAU_00580  ptsP; phosphoenolpyruvate-protein phosphotransferase pts (phosphotransferase system, enzyme i) (enzyme i-ntr) [KO:K08484] [EC:2.7.3.9]
PAU_03683  ptsO; phosphocarrier protein npr (nitrogen related hpr) [KO:K08485]
PAU_03681  ptsN; nitrogen regulatory iia protein (enzyme iia-ntr) (phosphotransferas enzyme ii, a component) [KO:K02806] [EC:2.7.1.-]
Compound
C00022  Pyruvate
C00031  D-Glucose
C00072  Ascorbate
C00074  Phosphoenolpyruvate
C00089  Sucrose
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00124  D-Galactose
C00140  N-Acetyl-D-glucosamine
C00159  D-Mannose
C00185  Cellobiose
C00208  Maltose
C00243  Lactose
C00275  D-Mannose 6-phosphate
C00329  D-Glucosamine
C00352  D-Glucosamine 6-phosphate
C00354  D-Fructose 1,6-bisphosphate
C00357  N-Acetyl-D-glucosamine 6-phosphate
C00392  Mannitol
C00644  D-Mannitol 1-phosphate
C00689  alpha,alpha'-Trehalose 6-phosphate
C00697  Nitrogen
C00794  D-Sorbitol
C01083  alpha,alpha-Trehalose
C01094  D-Fructose 1-phosphate
C01096  Sorbitol 6-phosphate
C01113  D-Galactose 6-phosphate
C01132  N-Acetyl-D-galactosamine
C01451  Salicin
C01452  Sorbose
C01674  Chitobiose
C01697  Galactitol
C01798  D-Glucoside
C02262  D-Galactosamine
C02713  N-Acetylmuramate
C02888  Sorbose 1-phosphate
C02995  Maltose 6'-phosphate
C03752  2-Amino-2-deoxy-D-gluconate
C04534  6-Phospho-beta-D-glucosyl-(1,4)-D-glucose
C05396  Lactose 6'-phosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C06311  Galactitol 1-phosphate
C06376  N-Acetyl-D-galactosamine 6-phosphate
C06377  D-Galactosamine 6-phosphate
C11544  2-O-(alpha-D-Mannosyl)-D-glycerate
C16186  L-Ascorbate 6-phosphate
C16488  Fructoselysine
C16489  Fructoselysine 6-phosphate
C16688  Sucrose 6-phosphate
C16698  N-Acetylmuramic acid 6-phosphate
C16699  2-O-(6-Phospho-alpha-mannosyl)-D-glycerate
C20589  D-Glucosaminate-6-phosphate
C20978  Glucoselysine
C20979  Glucoselysine-6-phosphate
C21152  N,N'-Diacetylchitobiose 6'-phosphate
Reference
  Authors
Darbon E, Galinier A, Le Coq D, Deutscher J.
  Title
Phosphotransfer functions mutated Bacillus subtilis HPr-like protein Crh carrying a histidine in the active site.
  Journal
J Mol Microbiol Biotechnol 3:439-44 (2001)
Reference
  Authors
Dahl U, Jaeger T, Nguyen BT, Sattler JM, Mayer C.
  Title
Identification of a phosphotransferase system of Escherichia coli required for growth on N-acetylmuramic acid.
  Journal
J Bacteriol 186:2385-92 (2004)
DOI:10.1128/JB.186.8.2385-2392.2004
Reference
PMID:2117666
  Authors
Martin-Verstraete I, Debarbouille M, Klier A, Rapoport G
  Title
Levanase operon of Bacillus subtilis includes a fructose-specific phosphotransferase system regulating the expression of the operon.
  Journal
J Mol Biol 214:657-71 (1990)
DOI:10.1016/0022-2836(90)90284-S
Reference
  Authors
Kristich CJ, Glekas GD, Ordal GW.
  Title
The conserved cytoplasmic module of the transmembrane chemoreceptor McpC mediates carbohydrate chemotaxis in Bacillus subtilis.
  Journal
Mol Microbiol 47:1353-66 (2003)
DOI:10.1046/j.1365-2958.2003.03375.x
Reference
  Authors
Sampaio MM, Chevance F, Dippel R, Eppler T, Schlegel A, Boos W, Lu YJ, Rock CO.
  Title
Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor.
  Journal
J Biol Chem 279:5537-48 (2004)
DOI:10.1074/jbc.M310980200
Reference
  Authors
Keseler IM, Collado-Vides J, Gama-Castro S, Ingraham J, Paley S, Paulsen IT, Peralta-Gil M, Karp PD.
  Title
EcoCyc: a comprehensive database resource for Escherichia coli.
  Journal
Nucleic Acids Res 33:D334-7 (2005)
DOI:10.1093/nar/gki108
Reference
  Authors
Mukherjee A, Mammel MK, LeClerc JE, Cebula TA.
  Title
Altered utilization of N-acetyl-D-galactosamine by Escherichia coli O157:H7 from the 2006 spinach outbreak.
  Journal
J Bacteriol 190:1710-7 (2008)
DOI:10.1128/JB.01737-07
Reference
  Authors
Brinkkotter A, Kloss H, Alpert C, Lengeler JW.
  Title
Pathways for the utilization of N-acetyl-galactosamine and galactosamine in Escherichia coli.
  Journal
Mol Microbiol 37:125-35 (2000)
DOI:10.1046/j.1365-2958.2000.01969.x
Reference
  Authors
Tchieu JH, Norris V, Edwards JS, Saier MH Jr.
  Title
The complete phosphotranferase system in Escherichia coli.
  Journal
J Mol Microbiol Biotechnol 3:329-46 (2001)
Reference
  Authors
Kotrba P, Inui M, Yukawa H.
  Title
Bacterial phosphotransferase system (PTS) in carbohydrate uptake and control of carbon metabolism.
  Journal
J Biosci Bioeng 92:502-17 (2001)
DOI:10.1016/S1389-1723(01)80308-X
Related
pathway
pay00051  Fructose and mannose metabolism
KO pathway
ko02060   

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