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Entry
pmr02060                    Pathway                                

Name
Phosphotransferase system (PTS) - Proteus mirabilis HI4320
Description
The phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) is a major mechanism used by bacteria for uptake of carbohydrates, particularly hexoses, hexitols, and disaccharides, where the source of energy is from PEP. The PTS consists of two general components, enzyme I (EI) and histidine phosphocarrier protein (HPr), and of membrane-bound sugar specific permeases (enzymes II). Each enzyme II (EII) complex consists of one or two hydrophobic integral membrane domains (domains C and D) and two hydrophilic domains (domains A and B). EII complexes may exist as distinct proteins or as a single multidomain protein. The PTS catalyzes the uptake of carbohydrates and their conversion into their respective phosphoesters during transport. There are four successive phosphoryl transfers in the PTS. Initial autophosphorylation of EI, using PEP as a substrate, is followed by transfer of the phosphoryl group from EI to HPr. EIIA catalyzes the self-phosphoryl transfer from HPr after which the phosphoryl group is transferred to histidine or cysteine residues of EIIB. The sugar is transported through the membrane-bound EIIC and is phosphorylated by the appropriate sugar-specific EIIB.
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
pmr02060  Phosphotransferase system (PTS)
pmr02060

Ortholog table
Module
pmr_M00265  PTS system, glucose-specific II component [PATH:pmr02060]
pmr_M00266  PTS system, maltose/glucose-specific II component [PATH:pmr02060]
pmr_M00267  PTS system, N-acetylglucosamine-specific II component [PATH:pmr02060]
pmr_M00270  PTS system, trehalose-specific II component [PATH:pmr02060]
pmr_M00271  PTS system, beta-glucoside-specific II component [PATH:pmr02060]
pmr_M00275  PTS system, cellobiose-specific II component [PATH:pmr02060]
pmr_M00277  PTS system, N-acetylgalactosamine-specific II component [PATH:pmr02060]
pmr_M00283  PTS system, ascorbate-specific II component [PATH:pmr02060]
Other DBs
BSID: 73056
GO: 0009401
TC: 4.A
Organism
Proteus mirabilis HI4320 [GN:pmr]
Gene
PMI1829  ptsI; phosphoenolpyruvate-protein phosphotransferase [KO:K08483] [EC:2.7.3.9]
PMI1828  hpr; PTS system phosphocarrier protein [KO:K02784]
PMI1830  crr; PTS family enzyme IIA component [KO:K02777] [EC:2.7.1.-]
PMI2292  ptsG; glucose-specific PTS system, EIIBC component [KO:K02778 K02779] [EC:2.7.1.199]
PMI0455  nagE; N-acetylglucosamine-specific PTS system, EIICBA component [KO:K02802 K02803 K02804] [EC:2.7.1.193 2.7.1.193]
PMI2982  PTS system, EIIBC component [KO:K02790 K02791] [EC:2.7.1.208 2.7.1.199]
PMI3515  PTS system EIIBC component [KO:K02809 K02810] [EC:2.7.1.211]
PMI2226  PTS system, IIabc component [KO:K02755 K02756 K02757] [EC:2.7.1.- 2.7.1.-]
PMI0291  treB; trehalose-specific PTS system, EIIBC component [KO:K02818 K02819] [EC:2.7.1.201]
PMI2954  chbA; N,N'-diacetylchitobiose-specific PTS system, EIIA component [KO:K02759] [EC:2.7.1.205 2.7.1.196]
PMI2956  chbB; N,N'-diacetylchitobiose-specific PTS system, EIIB component [KO:K02760] [EC:2.7.1.205 2.7.1.196]
PMI2955  chbC; N,N'-diacetylchitobiose-specific PTS system, EIIC component [KO:K02761]
PMI2135  agaF; putative N-acetylgalactosamine-specific PTS system, EIIA component [KO:K02744] [EC:2.7.1.-]
PMI2138  agaV; putative N-acetylgalactosamine-specific PTS system, EIIB component [KO:K02745] [EC:2.7.1.-]
PMI2137  agaW; putative N-acetylgalactosamine-specific PTS system, EIIC component [KO:K02746]
PMI2136  agaD; putative N-acetylgalactosamine-specific PTS system, EIID component [KO:K02747]
PMI1777  PTS system EIIA component [KO:K02821] [EC:2.7.1.194]
PMI1776  PTS system EIIB component [KO:K02822] [EC:2.7.1.194]
PMI1775  putative PTS system EIIC component [KO:K03475]
PMI2320  ptsP; phosphoenolpyruvate-protein phosphotransferase [KO:K08484] [EC:2.7.3.9]
PMI3644  ptsO; phosphocarrier protein [KO:K08485]
PMI3646  ptsN; nitrogen regulatory protein [includes: PTS system EIIA component] [KO:K02806] [EC:2.7.1.-]
Compound
C00022  Pyruvate
C00031  D-Glucose
C00072  Ascorbate
C00074  Phosphoenolpyruvate
C00089  Sucrose
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00124  D-Galactose
C00140  N-Acetyl-D-glucosamine
C00159  D-Mannose
C00185  Cellobiose
C00208  Maltose
C00243  Lactose
C00275  D-Mannose 6-phosphate
C00329  D-Glucosamine
C00352  D-Glucosamine 6-phosphate
C00357  N-Acetyl-D-glucosamine 6-phosphate
C00392  Mannitol
C00644  D-Mannitol 1-phosphate
C00689  alpha,alpha'-Trehalose 6-phosphate
C00697  Nitrogen
C00794  D-Sorbitol
C01083  alpha,alpha-Trehalose
C01094  D-Fructose 1-phosphate
C01096  Sorbitol 6-phosphate
C01113  D-Galactose 6-phosphate
C01132  N-Acetyl-D-galactosamine
C01451  Salicin
C01452  Sorbose
C01674  Chitobiose
C01697  Galactitol
C01798  D-Glucoside
C02262  D-Galactosamine
C02713  N-Acetylmuramate
C02888  Sorbose 1-phosphate
C02995  Maltose 6'-phosphate
C03752  2-Amino-2-deoxy-D-gluconate
C04534  6-Phospho-beta-D-glucosyl-(1,4)-D-glucose
C05396  Lactose 6'-phosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C06311  Galactitol 1-phosphate
C06376  N-Acetyl-D-galactosamine 6-phosphate
C06377  D-Galactosamine 6-phosphate
C11544  2-O-(alpha-D-Mannosyl)-D-glycerate
C16186  L-Ascorbate 6-phosphate
C16488  Fructoselysine
C16489  Fructoselysine 6-phosphate
C16688  Sucrose 6-phosphate
C16698  N-Acetylmuramic acid 6-phosphate
C16699  2-O-(6-Phospho-alpha-mannosyl)-D-glycerate
C20589  D-Glucosaminate-6-phosphate
C20978  Glucoselysine
C20979  Glucoselysine-6-phosphate
C21152  N,N'-Diacetylchitobiose 6'-phosphate
Reference
  Authors
Darbon E, Galinier A, Le Coq D, Deutscher J.
  Title
Phosphotransfer functions mutated Bacillus subtilis HPr-like protein Crh carrying a histidine in the active site.
  Journal
J Mol Microbiol Biotechnol 3:439-44 (2001)
Reference
  Authors
Dahl U, Jaeger T, Nguyen BT, Sattler JM, Mayer C.
  Title
Identification of a phosphotransferase system of Escherichia coli required for growth on N-acetylmuramic acid.
  Journal
J Bacteriol 186:2385-92 (2004)
DOI:10.1128/JB.186.8.2385-2392.2004
Reference
PMID:2117666
  Authors
Martin-Verstraete I, Debarbouille M, Klier A, Rapoport G
  Title
Levanase operon of Bacillus subtilis includes a fructose-specific phosphotransferase system regulating the expression of the operon.
  Journal
J Mol Biol 214:657-71 (1990)
DOI:10.1016/0022-2836(90)90284-S
Reference
  Authors
Kristich CJ, Glekas GD, Ordal GW.
  Title
The conserved cytoplasmic module of the transmembrane chemoreceptor McpC mediates carbohydrate chemotaxis in Bacillus subtilis.
  Journal
Mol Microbiol 47:1353-66 (2003)
DOI:10.1046/j.1365-2958.2003.03375.x
Reference
  Authors
Sampaio MM, Chevance F, Dippel R, Eppler T, Schlegel A, Boos W, Lu YJ, Rock CO.
  Title
Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor.
  Journal
J Biol Chem 279:5537-48 (2004)
DOI:10.1074/jbc.M310980200
Reference
  Authors
Keseler IM, Collado-Vides J, Gama-Castro S, Ingraham J, Paley S, Paulsen IT, Peralta-Gil M, Karp PD.
  Title
EcoCyc: a comprehensive database resource for Escherichia coli.
  Journal
Nucleic Acids Res 33:D334-7 (2005)
DOI:10.1093/nar/gki108
Reference
  Authors
Mukherjee A, Mammel MK, LeClerc JE, Cebula TA.
  Title
Altered utilization of N-acetyl-D-galactosamine by Escherichia coli O157:H7 from the 2006 spinach outbreak.
  Journal
J Bacteriol 190:1710-7 (2008)
DOI:10.1128/JB.01737-07
Reference
  Authors
Brinkkotter A, Kloss H, Alpert C, Lengeler JW.
  Title
Pathways for the utilization of N-acetyl-galactosamine and galactosamine in Escherichia coli.
  Journal
Mol Microbiol 37:125-35 (2000)
DOI:10.1046/j.1365-2958.2000.01969.x
Reference
  Authors
Tchieu JH, Norris V, Edwards JS, Saier MH Jr.
  Title
The complete phosphotranferase system in Escherichia coli.
  Journal
J Mol Microbiol Biotechnol 3:329-46 (2001)
Reference
  Authors
Kotrba P, Inui M, Yukawa H.
  Title
Bacterial phosphotransferase system (PTS) in carbohydrate uptake and control of carbon metabolism.
  Journal
J Biosci Bioeng 92:502-17 (2001)
DOI:10.1016/S1389-1723(01)80308-X
KO pathway
ko02060   

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