KEGG   PATHWAY: pmw03440Help
Entry
pmw03440                    Pathway                                

Name
Homologous recombination - Paenibacillus mucilaginosus K02
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
pmw03440  Homologous recombination
pmw03440

Ortholog table
Other DBs
BSID: 627530
GO: 0000724
Organism
Paenibacillus mucilaginosus K02 [GN:pmw]
Gene
B2K_30570  hypothetical protein [KO:K07462] [EC:3.1.-.-]
B2K_37660  single-stranded DNA-binding protein [KO:K03111]
B2K_00020  recombinase F [KO:K03629]
B2K_28305  DNA repair protein RecO [KO:K03584]
B2K_36170  recombinase RecR [KO:K06187]
B2K_26310  protein RecA [KO:K03553]
B2K_08240  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
B2K_30635  Holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
B2K_30630  Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
B2K_16230  hypothetical protein [KO:K01159] [EC:3.1.22.4]
B2K_30640  Holliday junction resolvase [KO:K01159] [EC:3.1.22.4]
B2K_27060  ATP-dependent DNA helicase [KO:K03655] [EC:3.6.4.12]
B2K_26495  polC; DNA polymerase III subunit alpha [KO:K03763] [EC:2.7.7.7]
B2K_00010  DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
B2K_24365  DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
B2K_36180  DNA polymerase III subunit gamma/tau [KO:K02343] [EC:2.7.7.7]
B2K_28550  DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
B2K_36125  ATPase [KO:K02341] [EC:2.7.7.7]
B2K_09785  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
B2K_27140  primosomal protein N' [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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