KEGG   PATHWAY: pps04672
Entry
pps04672                    Pathway                                

Name
Intestinal immune network for IgA production - Pan paniscus (bonobo)
Description
The intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies that serve as the first line of defense against microorganisms. The basic map of IgA production includes induction of mucosal B cells in the Peyer's patches, circulation through the bloodstream and homing to intestinal mucosa of IgA-commited plasma cells, and local antibody production for export across the intestinal membranes. Multiple cytokines, including TGF-{beta}, IL-10, IL-4, IL-5, and IL-6, are required to promote IgA class switching and terminal differentiation process of the B cells. Secreted IgA promotes immune exclusion by entrapping dietary antigens and microorganisms in the mucus and functions for neutralization of toxins and pathogenic microbes.
Class
Organismal Systems; Immune system
Pathway map
pps04672  Intestinal immune network for IgA production
pps04672

Other DBs
GO: 0002387
Organism
Pan paniscus (bonobo) [GN:pps]
Gene
100967832  CD80; CD80 molecule [KO:K05412]
100981251  CD86; CD86 molecule [KO:K05413]
100986750  HLA class II histocompatibility antigen, DRB1-4 beta chain [KO:K06752]
100987433  HLA class II histocompatibility antigen, DRB1-10 beta chain-like [KO:K06752]
100987081  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
100967723  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
100972641  HLA class II histocompatibility antigen, DQ beta 2 chain [KO:K06752]
100967376  RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752]
100979649  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
100968989  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
100968410  MHC-DMB; HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
100995577  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
100995226  Papa-DPB1; HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
100970847  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
100973583  HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752]
100972994  HLA class II histocompatibility antigen, DQ beta 1 chain [KO:K06752]
100993847  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
100993508  HLA class II histocompatibility antigen, DQ alpha 1 chain [KO:K06752]
100992093  CD28; CD28 molecule [KO:K06470]
100975083  uncharacterized LOC100975083 [KO:K10785]
100985012  uncharacterized LOC100985012 [KO:K10785]
100988366  uncharacterized LOC100988366 [KO:K10785]
100982662  uncharacterized LOC100982662 [KO:K10785]
100983000  uncharacterized LOC100983000 [KO:K10785]
100995080  uncharacterized LOC100995080 [KO:K10785]
100988045  uncharacterized LOC100988045 [KO:K10785]
100984780  IL2; interleukin 2 [KO:K05429]
100988878  IL4; interleukin 4 [KO:K05430]
100991249  IL5; interleukin 5 [KO:K05428]
100967827  IL6; interleukin 6 [KO:K05405]
100990760  IL10; interleukin 10 [KO:K05443]
100980947  TGFB1; transforming growth factor beta 1 [KO:K13375]
100978212  TNFSF13; tumor necrosis factor superfamily member 13 [KO:K05475]
100975430  TNFSF13B; tumor necrosis factor superfamily member 13b [KO:K05476]
100968537  TNFRSF13B; TNF receptor superfamily member 13B [KO:K05150]
100990622  TNFRSF17; TNF receptor superfamily member 17 [KO:K05153]
100983622  Ig heavy chain Mem5-like [KO:K06856]
100979030  putative V-set and immunoglobulin domain-containing-like protein IGHV1OR21-1 [KO:K06856]
100970186  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
103785315  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
103785316  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
100989153  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
100973347  AICDA; activation induced cytidine deaminase [KO:K10989] [EC:3.5.4.38]
100974274  CD40; CD40 molecule [KO:K03160]
100975410  CD40LG; CD40 ligand [KO:K03161]
100993375  ICOS; inducible T-cell costimulator [KO:K06713]
100995445  ICOSLG; inducible T-cell costimulator ligand [KO:K06710]
100976001  CCR9; C-C motif chemokine receptor 9 [KO:K04184]
100983460  ITGA4; integrin subunit alpha 4 [KO:K06483]
100989804  ITGB7; integrin subunit beta 7 [KO:K06590]
100974444  CXCL12; C-X-C motif chemokine ligand 12 [KO:K10031]
100968161  CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189]
100987853  CCL28; C-C motif chemokine ligand 28 [KO:K05513]
100968227  CCR10; C-C motif chemokine receptor 10 [KO:K04185]
100974396  CCL25; C-C motif chemokine ligand 25 [KO:K13072]
100973901  MADCAM1; mucosal vascular addressin cell adhesion molecule 1 [KO:K06779]
100982660  LTBR; lymphotoxin beta receptor [KO:K03159]
100984930  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
100988257  IL15; interleukin 15 [KO:K05433]
100994584  IL15RA; interleukin 15 receptor subunit alpha [KO:K05074]
100987708  PIGR; polymeric immunoglobulin receptor [KO:K13073]
Compound
C00777  Retinoate
C15493  9-cis-Retinoic acid
Reference
  Authors
Fagarasan S, Honjo T
  Title
Intestinal IgA synthesis: regulation of front-line body defences.
  Journal
Nat Rev Immunol 3:63-72 (2003)
DOI:10.1038/nri982
Reference
  Authors
Macpherson AJ, McCoy KD, Johansen FE, Brandtzaeg P
  Title
The immune geography of IgA induction and function.
  Journal
Mucosal Immunol 1:11-22 (2008)
DOI:10.1038/mi.2007.6
Reference
  Authors
Kunisawa J, Kiyono H
  Title
A marvel of mucosal T cells and secretory antibodies for the creation of first lines of defense.
  Journal
Cell Mol Life Sci 62:1308-21 (2005)
DOI:10.1007/s00018-005-5035-1
Reference
  Authors
Cerutti A, Rescigno M
  Title
The biology of intestinal immunoglobulin A responses.
  Journal
Immunity 28:740-50 (2008)
DOI:10.1016/j.immuni.2008.05.001
Reference
  Authors
Tsuji M, Suzuki K, Kinoshita K, Fagarasan S
  Title
Dynamic interactions between bacteria and immune cells leading to intestinal IgA synthesis.
  Journal
Semin Immunol 20:59-66 (2008)
DOI:10.1016/j.smim.2007.12.003
Reference
  Authors
Corthesy B
  Title
Roundtrip ticket for secretory IgA: role in mucosal homeostasis?
  Journal
J Immunol 178:27-32 (2007)
DOI:10.4049/jimmunol.178.1.27
Reference
  Authors
Suzuki K, Fagarasan S
  Title
How host-bacterial interactions lead to IgA synthesis in the gut.
  Journal
Trends Immunol 29:523-31 (2008)
DOI:10.1016/j.it.2008.08.001
Reference
  Authors
Mora JR, von Andrian UH
  Title
Differentiation and homing of IgA-secreting cells.
  Journal
Mucosal Immunol 1:96-109 (2008)
DOI:10.1038/mi.2007.14
Reference
  Authors
Suzuki K, Ha SA, Tsuji M, Fagarasan S
  Title
Intestinal IgA synthesis: a primitive form of adaptive immunity that regulates microbial communities in the gut.
  Journal
Semin Immunol 19:127-35 (2007)
DOI:10.1016/j.smim.2006.10.001
Reference
  Authors
Cerutti A
  Title
The regulation of IgA class switching.
  Journal
Nat Rev Immunol 8:421-34 (2008)
DOI:10.1038/nri2322
Related
pathway
pps04612  Antigen processing and presentation
pps04660  T cell receptor signaling pathway
pps04662  B cell receptor signaling pathway
pps04670  Leukocyte transendothelial migration
KO pathway
ko04672   

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