Entry |
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Name |
Intestinal immune network for IgA production - Pan paniscus (bonobo)
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Description |
The intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies that serve as the first line of defense against microorganisms. The basic map of IgA production includes induction of mucosal B cells in the Peyer's patches, circulation through the bloodstream and homing to intestinal mucosa of IgA-commited plasma cells, and local antibody production for export across the intestinal membranes. Multiple cytokines, including TGF-{beta}, IL-10, IL-4, IL-5, and IL-6, are required to promote IgA class switching and terminal differentiation process of the B cells. Secreted IgA promotes immune exclusion by entrapping dietary antigens and microorganisms in the mucus and functions for neutralization of toxins and pathogenic microbes.
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Class |
Organismal Systems; Immune system
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Pathway map |
pps04672 | Intestinal immune network for IgA production |

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Other DBs |
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Organism |
Pan paniscus (bonobo) [GN: pps]
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Gene |
100986750 | HLA class II histocompatibility antigen, DRB1-4 beta chain [KO:K06752] |
100987433 | HLA class II histocompatibility antigen, DRB1-10 beta chain-like [KO:K06752] |
100987081 | HLA class II histocompatibility antigen, DR alpha chain [KO:K06752] |
100967723 | HLA class II histocompatibility antigen, DO alpha chain [KO:K06752] |
100972641 | HLA class II histocompatibility antigen, DQ beta 2 chain [KO:K06752] |
100967376 | RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752] |
100979649 | HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752] |
100968989 | HLA class II histocompatibility antigen, DM alpha chain [KO:K06752] |
100968410 | MHC-DMB; HLA class II histocompatibility antigen, DM beta chain [KO:K06752] |
100995577 | HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752] |
100995226 | Papa-DPB1; HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752] |
100970847 | HLA class II histocompatibility antigen, DO beta chain [KO:K06752] |
100973583 | HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752] |
100972994 | HLA class II histocompatibility antigen, DQ beta 1 chain [KO:K06752] |
100993847 | HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752] |
100993508 | HLA class II histocompatibility antigen, DQ alpha 1 chain [KO:K06752] |
100975430 | TNFSF13B; tumor necrosis factor superfamily member 13b [KO:K05476] |
100979030 | putative V-set and immunoglobulin domain-containing-like protein IGHV1OR21-1 [KO:K06856] |
100970186 | putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856] |
103785315 | putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856] |
103785316 | putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856] |
100989153 | putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856] |
100973901 | MADCAM1; mucosal vascular addressin cell adhesion molecule 1 [KO:K06779] |
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Compound |
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Reference |
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Authors |
Fagarasan S, Honjo T |
Title |
Intestinal IgA synthesis: regulation of front-line body defences. |
Journal |
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Reference |
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Authors |
Macpherson AJ, McCoy KD, Johansen FE, Brandtzaeg P |
Title |
The immune geography of IgA induction and function. |
Journal |
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Reference |
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Authors |
Kunisawa J, Kiyono H |
Title |
A marvel of mucosal T cells and secretory antibodies for the creation of first lines of defense. |
Journal |
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Reference |
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Authors |
Cerutti A, Rescigno M |
Title |
The biology of intestinal immunoglobulin A responses. |
Journal |
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Reference |
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Authors |
Tsuji M, Suzuki K, Kinoshita K, Fagarasan S |
Title |
Dynamic interactions between bacteria and immune cells leading to intestinal IgA synthesis. |
Journal |
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Reference |
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Authors |
Corthesy B |
Title |
Roundtrip ticket for secretory IgA: role in mucosal homeostasis? |
Journal |
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Reference |
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Authors |
Suzuki K, Fagarasan S |
Title |
How host-bacterial interactions lead to IgA synthesis in the gut. |
Journal |
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Reference |
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Authors |
Mora JR, von Andrian UH |
Title |
Differentiation and homing of IgA-secreting cells. |
Journal |
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Reference |
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Authors |
Suzuki K, Ha SA, Tsuji M, Fagarasan S |
Title |
Intestinal IgA synthesis: a primitive form of adaptive immunity that regulates microbial communities in the gut. |
Journal |
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Reference |
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Authors |
Cerutti A |
Title |
The regulation of IgA class switching. |
Journal |
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Related pathway |
pps04612 | Antigen processing and presentation |
pps04660 | T cell receptor signaling pathway |
pps04662 | B cell receptor signaling pathway |
pps04670 | Leukocyte transendothelial migration |
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KO pathway |
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