KEGG   PATHWAY: pps05332
Entry
pps05332                    Pathway                                
Name
Graft-versus-host disease - Pan paniscus (bonobo)
Description
Graft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT) where immunocompetent donor T cells attack the genetically disparate host cells. GVHD pathophysiology can be summerized in a three-step process. Step 1 involves the development of an inflammatory milieu resulting from damage in the host tissues induced by the preparative chemotherapy or radiotherapy regimen. Damaged tissues secrete inflammatory cytokines, including interleukin 1 (IL-1), and tumor necrosis factor (TNF-alpha ). During step 2, antigen-presenting cells (APCs) trigger the activation of donor-derived T cells, which induce further T-cell expansion, induce cytotoxic T lymphocytes (CTL) and natural killer (NK) cells responses and prime additional mononuclear phagocytes to produce TNF-alpha and IL-1. Also, nitric oxide (NO) is produced by activated macrophages, and it may contribute to the tissue damage seen during step 3. During step 3, the effector phase, activated CTL and NK cells mediate cytotoxicity against target host cells through Fas-Fas ligand interactions and perforin-granzyme B.
Class
Human Diseases; Immune disease
Pathway map
pps05332  Graft-versus-host disease
pps05332

Disease
H00084  Graft-versus-host disease
Organism
Pan paniscus (bonobo) [GN:pps]
Gene
100967723  [KO:K06752]
100967827  IL6; interleukin-6 isoform X2 [KO:K05405]
100967832  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
100968410  MHC-DMB; HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
100968989  [KO:K06752]
100970360  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100970847  [KO:K06752]
100972641  [KO:K06752]
100972994  [KO:K06752]
100973583  [KO:K06752]
100977055  [KO:K06751]
100977674  TNF; tumor necrosis factor [KO:K03156]
100978112  Papa-A; patr class I histocompatibility antigen, A-2 alpha chain-like precursor [KO:K06751]
100978457  [KO:K06751]
100978774  [KO:K06751]
100979338  [KO:K06751]
100979649  [KO:K06752]
100979698  PRF1; perforin-1 isoform X2 [KO:K07818]
100981251  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
100982294  [KO:K06751]
100982859  [KO:K06751]
100984780  IL2; interleukin-2 [KO:K05429]
100986750  [KO:K06752]
100986982  [KO:K07980]
100987081  [KO:K06752]
100987153  GZMB; granzyme B [KO:K01353] [EC:3.4.21.79]
100988526  FAS; tumor necrosis factor receptor superfamily member 6 isoform X3 [KO:K04390]
100990924  [KO:K06541]
100991779  IFNG; interferon gamma [KO:K04687]
100992093  CD28; T-cell-specific surface glycoprotein CD28 isoform X2 [KO:K06470]
100992162  KLRD1; natural killer cells antigen CD94 isoform X1 [KO:K06516]
100992623  [KO:K07980]
100993452  [KO:K06751]
100993613  IL1B; interleukin-1 beta [KO:K04519]
100994016  [KO:K07980]
100994286  IL1A; interleukin-1 alpha [KO:K04383]
100995226  [KO:K06752]
100995577  [KO:K06752]
117977013  [KO:K07980]
134728424  [KO:K07980]
134729565  [KO:K07980]
134729566  [KO:K07980]
134729568  [KO:K07980]
134729569  [KO:K07980]
134729572  [KO:K07981]
134730587  [KO:K06752]
Compound
C00338  Lipopolysaccharide
C00533  Nitric oxide
Reference
  Authors
Ferrara JL, Reddy P.
  Title
Pathophysiology of graft-versus-host disease.
  Journal
Semin Hematol 43:3-10 (2006)
DOI:10.1053/j.seminhematol.2005.09.001
Reference
  Authors
Reddy P.
  Title
Pathophysiology of acute graft-versus-host disease.
  Journal
Hematol Oncol 21:149-61 (2003)
DOI:10.1002/hon.716
Reference
  Authors
Sun Y, Tawara I, Toubai T, Reddy P.
  Title
Pathophysiology of acute graft-versus-host disease: recent advances.
  Journal
Transl Res 150:197-214 (2007)
DOI:10.1016/j.trsl.2007.06.003
Reference
  Authors
Jaksch M, Mattsson J.
  Title
The pathophysiology of acute graft-versus-host disease.
  Journal
Scand J Immunol 61:398-409 (2005)
DOI:10.1111/j.1365-3083.2005.01595.x
Reference
  Authors
Vogelsang GB, Lee L, Bensen-Kennedy DM.
  Title
Pathogenesis and treatment of graft-versus-host disease after bone marrow transplant.
  Journal
Annu Rev Med 54:29-52 (2003)
DOI:10.1146/annurev.med.54.101601.152339
Reference
  Authors
Reddy P, Ferrara JL.
  Title
Immunobiology of acute graft-versus-host disease.
  Journal
Blood Rev 17:187-94 (2003)
DOI:10.1016/S0268-960X(03)00009-2
Reference
  Authors
Blazar BR, Murphy WJ.
  Title
Bone marrow transplantation and approaches to avoid graft-versus-host disease (GVHD).
  Journal
Philos Trans R Soc Lond B Biol Sci 360:1747-67 (2005)
DOI:10.1098/rstb.2005.1701
Reference
  Authors
Couriel D, Caldera H, Champlin R, Komanduri K.
  Title
Acute graft-versus-host disease: pathophysiology, clinical manifestations, and management.
  Journal
Cancer 101:1936-46 (2004)
DOI:10.1002/cncr.20613
Reference
  Authors
Jacobsohn DA, Vogelsang GB.
  Title
Acute graft versus host disease.
  Journal
Orphanet J Rare Dis 2:35 (2007)
DOI:10.1186/1750-1172-2-35
Related
pathway
pps04060  Cytokine-cytokine receptor interaction
pps04210  Apoptosis
pps04514  Cell adhesion molecules
pps04612  Antigen processing and presentation
pps04620  Toll-like receptor signaling pathway
pps04650  Natural killer cell mediated cytotoxicity
pps04660  T cell receptor signaling pathway
KO pathway
ko05332   

  All links  
No link information was found.   
DBGET integrated database retrieval system