KEGG   PATHWAY: pti04145Help
Entry
pti04145                    Pathway                                

Name
Phagosome - Phaeodactylum tricornutum
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
pti04145  Phagosome
pti04145

Ortholog table
Other DBs
BSID: 153953
GO: 0045335
Organism
Phaeodactylum tricornutum [GN:pti]
Gene
PHATRDRAFT_29812  hypothetical protein [KO:K05692]
PHATRDRAFT_51157  ACT1; actin/actin like protein [KO:K05692]
PHATRDRAFT_54066  SybE; hypothetical protein [KO:K08517]
PHATRDRAFT_51511  Rab5a; hypothetical protein [KO:K07889]
PHATRDRAFT_30282  hypothetical protein [KO:K00914] [EC:2.7.1.137]
PHATRDRAFT_27923  hypothetical protein [KO:K02145] [EC:3.6.3.14]
PHATRDRAFT_24978  hypothetical protein [KO:K02147]
PHATRDRAFT_55482  det3-like protein [KO:K02148]
PHATRDRAFT_51058  hypothetical protein [KO:K02149]
PHATRDRAFT_29711  hypothetical protein [KO:K02150]
PHATRDRAFT_31133  hypothetical protein [KO:K02151]
PHATR_44050  hypothetical protein [KO:K02152]
PHATRDRAFT_28794  hypothetical protein [KO:K02154]
PHATR_21030  hypothetical protein [KO:K02146]
PHATRDRAFT_43023  hypothetical protein [KO:K02144]
PHATRDRAFT_21882  hypothetical protein [KO:K02155]
PHATRDRAFT_15145  hypothetical protein [KO:K02155]
PHATRDRAFT_22609  hypothetical protein [KO:K02155]
PHATRDRAFT_23706  hypothetical protein [KO:K02155]
PHATRDRAFT_29011  hypothetical protein [KO:K02155]
PHATRDRAFT_11649  hypothetical protein [KO:K03661]
PHATRDRAFT_51199  Rab7; hypothetical protein [KO:K07897]
PHATRDRAFT_31156  DHC1; hypothetical protein [KO:K10413]
PHATRDRAFT_46969  hypothetical protein [KO:K10415]
PHATRDRAFT_54534  hypothetical protein [KO:K07374]
PHATR_21122  hypothetical protein [KO:K07375]
PHATRDRAFT_25433  hypothetical protein [KO:K01365] [EC:3.4.22.15]
PHATRDRAFT_56443  Sec61alpha; transport protein Sec61 alpha subunit [KO:K10956]
PHATRDRAFT_17885  hypothetical protein [KO:K07342]
PHATRDRAFT_41172  calreticulin [KO:K08057]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Reference
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
KO pathway
ko04145   

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