KEGG   PATHWAY: rfe03440Help
Entry
rfe03440                    Pathway                                

Name
Homologous recombination - Rickettsia felis
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
rfe03440  Homologous recombination
rfe03440

Ortholog table
Module
rfe_M00260  DNA polymerase III complex, bacteria [PATH:rfe03440]
Other DBs
BSID: 24565
GO: 0000724
Organism
Rickettsia felis [GN:rfe]
Gene
RF_0763  recJ; Single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
RF_1325  ssb; Single-stranded DNA-binding protein [KO:K03111]
RF_0035  recF; DNA replication and repair protein RecF [KO:K03629]
RF_0868  recO; DNA repair protein RecO [KO:K03584]
RF_0672  recR; Recombination protein RecR [KO:K06187]
RF_1221  recA; RecA protein [KO:K03553]
RF_1239  polA; DNA polymerase I (POL I) [KO:K02335] [EC:2.7.7.7]
RF_0604  ruvA; Holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
RF_0606  ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
RF_1173  ruvC; Crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.22.4]
RF_0378  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
RF_1244  dnaE; DNA polymerase III alpha chain [KO:K02337] [EC:2.7.7.7]
RF_0649  dnaN; DNA polymerase III beta chain [KO:K02338] [EC:2.7.7.7]
RF_1364  dnaX; DNA polymerase III gamma and tau chains [KO:K02343] [EC:2.7.7.7]
RF_1078  holA; DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
RF_1107  holB; DNA polymerase III delta subunit [KO:K02341] [EC:2.7.7.7]
RF_0176  dnaQ; DNA polymerase III epsilon chain [KO:K02342] [EC:2.7.7.7]
RF_p34  DNA polymerase III, epsilon subunit-like protein [KO:K02342] [EC:2.7.7.7]
RF_1375  unknown [KO:K02339] [EC:2.7.7.7]
RF_0858  priA; Primosomal protein N' [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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