KEGG   PATHWAY: rn00450
Entry
rn00450                     Pathway                                
Name
Selenocompound metabolism
Class
Metabolism; Metabolism of other amino acids
Pathway map
rn00450  Selenocompound metabolism
rn00450

Reaction
R03595  ATP:selenide, water phosphotransferase
R03596  hydrogen selenide:NADP+ oxidoreductase
R03599  L-selenocysteine selenide-lyase (L-alanine-forming)
R04770  selenomethionine methanethiol-lyase (deaminating)
R04772  S-adenosyl-L-methionine:L-methionine S-methyltransferase
R04773  selenomethionine:tRNAMet ligase (AMP-forming)
R04929  ATP:selenate adenylyltransferase
R04931  S-adenosyl-L-methionine:thiol S-methyltransferase
R04941  selenocystathionine L-homocysteine-lyase (deaminating)
R04944  O-phosphorylhomoserine:selenocysteine Se-(3-amino-3-carboxypropyl)transferase
R04946  O4-succinyl-L-homoserine:L-selenocysteine Se-(3-amino-3-carboxypropyl)transferase
R07229  selenite:reduced acceptor oxidoreductase
R08219  selenophosphate:L-seryl-tRNASec selenium transferase
R08223  L-seryl-tRNA(Sec) kinase
R08224  selenophosphate:O-phospho-L-seryl-tRNA(Sec) selenium transferase
R09365  5-methyltetrahydropteroyltri-L-glutamate:L-selenohomocysteine Se-methyltransferase
R09366  Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating; pyruvate-forming)
R09367   
R09368   
R09369  S-adenosyl-L-methionine:methaneselenol Se-methyltransferase
R09370  S-adenosyl-L-methionine:dimethyl-selenide Se-methyltransferase
R09371  S-adenosyl-L-methionine:hydrogen-selenide Se-methyltransferase
R09372  methaneselenol:NADP+ oxidoreductase
R09373  L-methionine:methylselenopyruvate aminotransferase
Compound
C00017  Protein
C00041  L-Alanine
C01528  Hydrogen selenide
C02535  Dimethyl selenide
C05172  Selenophosphoric acid
C05335  L-Selenomethionine
C05336  Selenomethionyl-tRNA(Met)
C05684  Selenite
C05686  Adenylylselenate
C05688  L-Selenocysteine
C05689  Se-Methyl-L-selenocysteine
C05690  Se-Methylselenomethionine
C05695  gamma-Glutamyl-Se-methylselenocysteine
C05697  Selenate
C05698  Selenohomocysteine
C05699  L-Selenocystathionine
C05703  Methaneselenol
C06481  L-Seryl-tRNA(Sec)
C06482  L-Selenocysteinyl-tRNA(Sec)
C16638  O-Phosphoseryl-tRNA(Sec)
C18870  Selenodiglutathione
C18871  Glutathioselenol
C18872  Trimethylselenonium
C18893  1-Methylseleno-N-acetyl-D-galactosamine
C18902  Methylselenic acid
C18904  Methylselenopyruvate
C18905  Methylselenocysteine Se-oxide
Reference
PMID:21190829
  Authors
Hoefig CS, Renko K, Kohrle J, Birringer M, Schomburg L
  Title
Comparison of different selenocompounds with respect to nutritional value vs. toxicity using liver cells in culture.
  Journal
J Nutr Biochem 22:945-55 (2011)
DOI:10.1016/j.jnutbio.2010.08.006
Reference
PMID:19051051
  Authors
McKenzie MJ, Hunter DA, Pathirana R, Watson LM, Joyce NI, Matich AJ, Rowan DD, Brummell DA
  Title
Accumulation of an organic anticancer selenium compound in a transgenic Solanaceous species shows wider applicability of the selenocysteine methyltransferase transgene from selenium hyperaccumulators.
  Journal
Transgenic Res 18:407-24 (2009)
DOI:10.1007/s11248-008-9233-0
Reference
PMID:20383543
  Authors
Pinto JT, Lee JI, Sinha R, MacEwan ME, Cooper AJ
  Title
Chemopreventive mechanisms of alpha-keto acid metabolites of naturally occurring organoselenium compounds.
  Journal
Amino Acids 41:29-41 (2011)
DOI:10.1007/s00726-010-0578-3
Reference
PMID:17451884
  Authors
Suzuki KT, Kurasaki K, Suzuki N
  Title
Selenocysteine beta-lyase and methylselenol demethylase in the metabolism of Se-methylated selenocompounds into selenide.
  Journal
Biochim Biophys Acta 1770:1053-61 (2007)
DOI:10.1016/j.bbagen.2007.03.007
Reference
PMID:11782468
  Authors
Gromer S, Gross JH
  Title
Methylseleninate is a substrate rather than an inhibitor of mammalian thioredoxin reductase. Implications for the antitumor effects of selenium.
  Journal
J Biol Chem 277:9701-6 (2002)
DOI:10.1074/jbc.M109234200
KO pathway
ko00450   

  All links  
Chemical reaction (45)   
   KEGG REACTION (24)   
   KEGG RCLASS (21)   
All databases (45)   

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