KEGG   PATHWAY: rn00512
Entry
rn00512                     Pathway                                

Name
Mucin type O-glycan biosynthesis
Description
O-glycans are a class of glycans that modify serine or threonine residues of proteins. Biosynthesis of O-glycans starts from the transfer of N-acetylgalactosamine (GalNAc) to serine or threonine. The first GalNAc may be extended with sugars including galactose, N-acetylglucosamine, fucose, or sialic acid, but not mannose, glucose, or xylose. Depending on the sugars added, there are four common O-glycan core structures, cores 1 through 4, and an additional four, cores 5 though 8. Mucins are highly O-glycosylated glycoproteins ubiquitous in mucous secretions on cell surfaces and in body fluids. Mucin O-glycans can be branched, and many sugars or groups of sugars are antigenic. Important modifications of mucin O-glycans include O-acetylation of sialic acid and O-sulfation of galactose and N-acetylglucosamine.
Class
Metabolism; Glycan biosynthesis and metabolism
Pathway map
rn00512  Mucin type O-glycan biosynthesis
rn00512

Module
M00056  O-glycan biosynthesis, mucin type core [PATH:rn00512]
Other DBs
GO: 0006493
Reaction
R05907   
R05908   
R05909   
R05910   
R05911   
R05912   
R05913   
R05914   
R05915   
R07628   
Compound
C02189  [Protein]-L-serine
G00023  Tn antigen
G00024  T antigen
G00025   
G00026   
G00027   
G00028   
G00029   
G00030   
G00031   
G00032   
G00033   
G00034   
G00035  Sialyl-Tn antigen
G10611  UDP-N-acetyl-D-galactosamine
Reference
  Authors
Brockhausen I.
  Title
Pathways of O-glycan biosynthesis in cancer cells.
  Journal
Biochim Biophys Acta 1473:67-95 (1999)
DOI:10.1016/S0304-4165(99)00170-1
Reference
  Authors
Iwai T, Inaba N, Naundorf A, Zhang Y, Gotoh M, Iwasaki H, Kudo T, Togayachi A, Ishizuka Y, Nakanishi H, Narimatsu H.
  Title
Molecular cloning and characterization of a novel UDP-GlcNAc:GalNAc-peptide beta1,3-N-acetylglucosaminyltransferase (beta 3Gn-T6), an enzyme synthesizing the core 3 structure of O-glycans.
  Journal
J Biol Chem 277:12802-9 (2002)
DOI:10.1074/jbc.M112457200
Reference
  Authors
Korekane H, Taguchi T, Sakamoto Y, Honke K, Dohmae N, Salminen H, Toivonen S, Helin J, Takio K, Renkonen O, Taniguchi N.
  Title
Purification and cDNA cloning of UDP-GlcNAc:GlcNAcbeta1-3Galbeta1-4Glc(NAc)-R [GlcNAc to Gal]beta1,6N-acetylglucosaminyltransferase from rat small intestine: a major carrier of dIGnT activity in rat small intestine.
  Journal
Glycobiology 13:387-400 (2003)
DOI:10.1093/glycob/cwg044
Reference
  Authors
van Die I, van Tetering A, Schiphorst WE, Sato T, Furukawa K, van den Eijnden DH.
  Title
The acceptor substrate specificity of human beta4-galactosyltransferase V indicates its potential function in O-glycosylation.
  Journal
FEBS Lett 450:52-6 (1999)
DOI:10.1016/S0014-5793(99)00462-7
KO pathway
ko00512   

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