Entry |
|
Name |
Polyketide sugar unit biosynthesis |
Class |
Metabolism; Metabolism of terpenoids and polyketides
|
Pathway map |
rn00523 | Polyketide sugar unit biosynthesis |

|
Module |
M00793 | dTDP-L-rhamnose biosynthesis, glucose-1P => dTDP-L-Rha [PATH:rn00523] |
|
Reaction |
R02328 | dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase |
R02773 | dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase |
R02776 | dTDP-6-deoxy-L-talose:NADP+ 4-oxidoreductase |
R02777 | dTDP-beta-L-rhamnose:NADP+ 4-oxidoreductase; dTDP-6-deoxy-L-mannose:NADP+ 4-oxidoreductase |
R05518 | dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose hydro-lyase (dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose-forming) |
R05526 | dTDP-4-oxo-2,6-dideoxy-D-glucose:NADP+ 3-oxidoreductase |
R05687 | dTDP-4-keto-6-deoxyglucose reductase |
R06423 | dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose:2-oxoglutarate aminotransferase |
R06424 | dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose:dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose isomerase |
R06426 | dTDP-3-amino-3,4,6-trideoxy-D-glucose:2-oxoglutarate aminotransferase |
R06427 | S-adenosyl-L-methionine:dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose 3-N,N-dimethyltransferase |
R06433 | dTDP-4-oxo-2,6-dideoxy-D-allose 5-epimerase |
R06436 | dTDP-L-mycarose:NADP+ 4-oxidoreductase |
R06437 | dTDP-4-dehydro-6-deoxy-alpha-D-glucose 3-epimerase |
R06438 | dTDP-6-deoxy-alpha-D-allose:NAD+ oxidoreductase |
R06439 | S-adenosyl-L-methionine:dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose 3-N,N-dimethyltransferase |
R06513 | dTDPglucose 4,6-hydro-lyase |
R06514 | dTDP-4-dehydro-6-deoxy-alpha-D-glucose 3,5-epimerase; dTDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase |
R06631 | dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose:2-oxoglutarate aminotransferase |
R08583 | dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase (dTDP-3-oxo-4,6-dideoxy-D-glucose-forming) |
R08597 | dTDP-4-oxo-2,6-dideoxy-D-glucose 3,5-epimerase |
R08930 | dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose hydro-lyase (dTDP-2,3,6-trideoxy-alpha-D-hexopyranose-forming) |
R08931 | dTDP-4-amino-2,3,4,6-tetradeoxy-D-glucose:2-oxoglutarate aminotransferase |
R08932 | S-adenosyl-L-methionine:dTDP-4-amino-2,3,4,6-tetradeoxy-D-glucose N,N-dimethyltransferase |
R08933 | S-adenosyl-L-methionine:dTDP-4-oxo-2,6-dideoxy-D-allose 3-C-methyltransferase |
R08934 | dTDP-3-methyl-4-oxo-2,6-dideoxy-D-glucose 5-epimerase |
R08935 | dTDP-6-deoxy-L-mannose:NADP+ 4-oxidoreductase (3,5-epimerizing) |
R09821 | S-adenosyl-L-methionine:dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N,N-dimethyltransferase |
R09824 | dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose:2-oxoglutarate aminotransferase |
R09873 | acetyl-CoA:dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N-acetyltransferase |
R09904 | dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose:dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose isomerase |
R10190 | dTDP-6-deoxy-beta-L-talose:NAD+ 4-oxidoreductase |
R10279 | dTDP-6-deoxy-beta-L-talose 4-epimerase |
R10459 | dTDP-5-dimethyl-L-lyxose:NAD+ 4-oxidoreductase |
R10536 | dTDP-alpha-D-fucopyranose furanomutase |
R10573 | dTDP-6-deoxy-alpha-D-allose:NADP+ oxidoreductase |
R11020 | S-adenosyl-L-methionine:dTDP-4-oxo-6-deoxy-D-allose 5-C-methyltransferase |
R11041 | S-adenosyl-L-methionine:dTDP-4-oxo-2,6-dideoxy-L-mannose 3-O-methyltransferase |
R11045 | S-adenosyl-L-methionine:dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose 3-N,N-dimethyltransferase |
R11046 | dTDP-3-N,N-dimethylamino-2,3,6-trideoxy-4-keto-D-glucose 5-epimerase |
R11051 | dTDP-4-oxo-2,6-dideoxy-D-allose:NADP+ 3-oxidoreductase |
R11468 | dTDP-4-amino-4,6-dideoxy-D-glucose:reduced-ferredoxin:oxygen oxidoreductase |
R11469 | S-adenosyl-L-methionine:dTDP-L-rhamnose 3'-O-methyltransferase |
R11471 | dTDP-glucose:NAD+ 6-oxidoreductase |
R11472 | dTDP-D-glucuronate:NAD+ oxidoreductase (decarboxylating) |
R11473 | dTDP-4-oxo-alpha-D-xylose hydro-lyase (dTDP-4-oxo-2-deoxy-alpha-D-pentos-2-ene-forming) |
R11474 | dTDP-4-oxo-2-deoxy-beta-L-xylose:NADP+ oxidoreductase |
R11475 | dTDP-4-amino-2,4-dideoxy-beta-L-xylose:2-oxoglutarate aminotransferase |
R11476 | S-adenosyl-L-methionine:dTDP-4-amino-2,4-dideoxy-beta-L-xylose N-methyltransferase |
|
Compound |
C00688 | dTDP-4-dehydro-beta-L-rhamnose |
C03187 | dTDP-6-deoxy-beta-L-talose |
C04268 | dTDP-4-amino-4,6-dideoxy-D-glucose |
C06620 | dTDP-3,4-dioxo-2,6-dideoxy-D-glucose |
C11447 | dTDP-4-dimethylamino-4,6-dideoxy-5-C-methyl-D-allose |
C11460 | dTDP-4-oxo-5-C-methyl-L-rhamnose |
C11461 | dTDP-4-amino-4,6-dideoxy-5-C-methyl-D-allose |
C11907 | dTDP-4-oxo-6-deoxy-D-glucose |
C11908 | dTDP-3-oxo-6-deoxy-D-glucose |
C11909 | dTDP-3-oxo-4,6-dideoxy-D-glucose |
C11910 | dTDP-3-amino-3,4,6-trideoxy-D-glucose |
C11915 | dTDP-3-methyl-4-oxo-2,6-dideoxy-L-allose |
C11922 | dTDP-4-oxo-2,6-dideoxy-D-glucose |
C11925 | dTDP-3-amino-3,6-dideoxy-D-glucose |
C11926 | dTDP-4-oxo-6-deoxy-D-allose |
C11927 | dTDP-4-oxo-2,6-dideoxy-L-mannose |
C11928 | dTDP-4-oxo-2,6-dideoxy-D-allose |
C12318 | dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose |
C12481 | dTDP-5-dimethyl-L-lyxose |
C18029 | dTDP-3-oxo-2,6-dideoxy-D-glucose |
C18030 | dTDP-2,6-dideoxy-D-kanosamine |
C18032 | dTDP-4-oxo-2,3,6-trideoxy-D-glucose |
C18033 | dTDP-4-amino-2,3,4,6-tetradeoxy-D-glucose |
C18035 | dTDP-3-methyl-4-oxo-2,6-dideoxy-D-glucose |
C19947 | dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose |
C19948 | dTDP-3-dimethylamino-3,6-dideoxy-alpha-D-galactopyranose |
C19960 | dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose |
C20156 | dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose |
C20682 | dTDP-alpha-D-fucofuranose |
C21071 | dTDP-3-O-methyl-4-oxo-2,6-dideoxy-L-mannose |
C21073 | dTDP-3-N,N-dimethylamino-2,3,6-trideoxy-4-keto-D-glucose |
C21074 | dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-L-allose |
C21348 | dTDP-4-hydroxyamino-4,6-dideoxy-alpha-D-glucose |
C21349 | dTDP-4-deoxy-4-thio-alpha-D-digitoxose |
C21350 | dTDP-3-O-methyl-beta-L-rhamnose |
C21351 | dTDP-4-oxo-alpha-D-xylose |
C21352 | dTDP-4-oxo-2-deoxy-alpha-D-pentos-2-ene |
C21353 | dTDP-4-oxo-2-deoxy-beta-L-xylose |
C21354 | dTDP-4-amino-2,4-dideoxy-beta-L-xylose |
C21355 | dTDP-4-methylamino-2,4-dideoxy-beta-L-xylose |
C21356 | dTDP-4-ethylamino-3-O-methyl-2,4-dideoxy-L-threo-pentopyranose |
C21362 | dTDP-3-methyl-4-oxo-alpha-D-ribopyranose |
|
Reference |
|
Authors |
Rawlings BJ. |
Title |
Type I polyketide biosynthesis in bacteria (Part A--erythromycin biosynthesis). |
Journal |
|
Reference |
|
Authors |
Rawlings BJ. |
Title |
Type I polyketide biosynthesis in bacteria (part B). |
Journal |
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Reference |
|
Authors |
Wohlert S, Lomovskaya N, Kulowski K, Fonstein L, Occi JL, Gewain KM, MacNeil DJ, Hutchinson CR |
Title |
Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans. |
Journal |
|
Reference |
|
Authors |
Bate N, Butler AR, Smith IP, Cundliffe E |
Title |
The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin. |
Journal |
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Reference |
|
Authors |
Amann S, Drager G, Rupprath C, Kirschning A, Elling L |
Title |
(Chemo)enzymatic synthesis of dTDP-activated 2,6-dideoxysugars as building blocks of polyketide antibiotics. |
Journal |
|
Reference |
|
Authors |
Thibodeaux CJ, Melancon CE, Liu HW |
Title |
Unusual sugar biosynthesis and natural product glycodiversification. |
Journal |
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Reference |
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Authors |
Volchegursky Y, Hu Z, Katz L, McDaniel R |
Title |
Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea. |
Journal |
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Reference |
|
Authors |
Mironov VA, Sergienko OV, Nastasiak IN, Danilenko VN. |
Title |
Biogenesis and regulation of biosynthesis of erythromycins in Saccharopolyspora. |
Journal |
|
Reference |
|
Authors |
Tello M, Jakimowicz P, Errey JC, Freel Meyers CL, Walsh CT, Buttner MJ, Lawson DM, Field RA |
Title |
Characterisation of Streptomyces spheroides NovW and revision of its functional assignment to a dTDP-6-deoxy-D-xylo-4-hexulose 3-epimerase. |
Journal |
|
Reference |
|
Authors |
Takahashi H, Liu YN, Chen H, Liu HW |
Title |
Biosynthesis of TDP-l-mycarose: the specificity of a single enzyme governs the outcome of the pathway. |
Journal |
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Reference |
|
Authors |
Aguirrezabalaga I, Olano C, Allende N, Rodriguez L, Brana AF, Mendez C, Salas JA |
Title |
Identification and expression of genes involved in biosynthesis of L-oleandrose and its intermediate L-olivose in the oleandomycin producer Streptomyces antibioticus. |
Journal |
|
Reference |
|
Authors |
Rodriguez L, Rodriguez D, Olano C, Brana AF, Mendez C, Salas JA |
Title |
Functional analysis of OleY L-oleandrosyl 3-O-methyltransferase of the oleandomycin biosynthetic pathway in Streptomyces antibioticus. |
Journal |
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Reference |
|
Authors |
Useglio M, Peiru S, Rodriguez E, Labadie GR, Carney JR, Gramajo H |
Title |
TDP-L-megosamine biosynthesis pathway elucidation and megalomicin a production in Escherichia coli. |
Journal |
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Reference |
|
Authors |
Liu W, Christenson SD, Standage S, Shen B |
Title |
Biosynthesis of the enediyne antitumor antibiotic C-1027. |
Journal |
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Reference |
|
Authors |
Van Lanen SG, Oh TJ, Liu W, Wendt-Pienkowski E, Shen B |
Title |
Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis. |
Journal |
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Reference |
|
Authors |
Gao Q, Zhang C, Blanchard S, Thorson JS |
Title |
Deciphering indolocarbazole and enediyne aminodideoxypentose biosynthesis through comparative genomics: insights from the AT2433 biosynthetic locus. |
Journal |
|
Reference |
|
Authors |
Simkhada D, Oh TJ, Kim EM, Yoo JC, Sohng JK |
Title |
Cloning and characterization of CalS7 from Micromonospora echinospora sp. calichensis as a glucose-1-phosphate nucleotidyltransferase. |
Journal |
|
Reference |
|
Authors |
Singh S, Peltier-Pain P, Tonelli M, Thorson JS |
Title |
A general NMR-based strategy for the in situ characterization of sugar-nucleotide-dependent biosynthetic pathways. |
Journal |
|
Reference |
|
Authors |
Singh S, Chang A, Helmich KE, Bingman CA, Wrobel RL, Beebe ET, Makino S, Aceti DJ, Dyer K, Hura GL, Sunkara M, Morris AJ, Phillips GN Jr, Thorson JS |
Title |
Structural and functional characterization of CalS11, a TDP-rhamnose 3'-O-methyltransferase involved in calicheamicin biosynthesis. |
Journal |
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Reference |
|
Authors |
Liang ZX |
Title |
Complexity and simplicity in the biosynthesis of enediyne natural products. |
Journal |
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Reference |
|
Authors |
Singh S, Michalska K, Bigelow L, Endres M, Kharel MK, Babnigg G, Yennamalli RM, Bingman CA, Joachimiak A, Thorson JS, Phillips GN Jr |
Title |
Structural Characterization of CalS8, a TDP-alpha-D-Glucose Dehydrogenase Involved in Calicheamicin Aminodideoxypentose Biosynthesis. |
Journal |
|
Reference |
|
Authors |
Peltier-Pain P, Singh S, Thorson JS |
Title |
Characterization of Early Enzymes Involved in TDP-Aminodideoxypentose Biosynthesis en Route to Indolocarbazole AT2433. |
Journal |
|
Reference |
|
Authors |
Singh S, Kim Y, Wang F, Bigelow L, Endres M, Kharel MK, Babnigg G, Bingman CA, Joachimiak A, Thorson JS, Phillips GN Jr |
Title |
Structural characterization of AtmS13, a putative sugar aminotransferase involved in indolocarbazole AT2433 aminopentose biosynthesis. |
Journal |
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Related pathway |
rn00520 | Amino sugar and nucleotide sugar metabolism |
rn00522 | Biosynthesis of 12-, 14- and 16-membered macrolides |
rn01059 | Biosynthesis of enediyne antibiotics |
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KO pathway |
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