KEGG   PATHWAY: rn00830
Entry
rn00830                     Pathway                                

Name
Retinol metabolism
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
rn00830  Retinol metabolism
rn00830

Other DBs
GO: 0006776
Reaction
R00032  beta-carotene:oxygen 15,15'-oxidoreductase (bond-cleaving)
R02123  retinal:NAD+ oxidoreductase
R02124  retinol:NAD+ oxidoreductase
R02125  retinal:oxygen oxidoreductase
R02127   
R02128   
R02366  Acyl-CoA:retinol O-acyltransferase
R02367  Palmitoyl-CoA:retinol O-acyltransferase
R02368  retinyl-palmitate palmitohydrolase
R02902   
R02904   
R02905   
R03048  11-cis-retinol:NAD+ oxidoreductase
R03049  11-cis-Retinyl-palmitate acylhydrolase
R03836   
R05041   
R06194   
R07163  all-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductas
R08379  retinol: NADP+ oxidoreductase
R08380  11-cis-retinol: NADP+ oxidoreductase
R08381  Palmitoyl-CoA:retinol O-acyltransferase
R08382  9-cis-retinol:NAD+ oxidoreductase
R08383   
R08384  retinal:oxygen oxidoreductase
R08385  retinal:NAD+ oxidoreductase
R08387  phosphatidylcholine:retinol O-acyltransferase
R08388  all-trans-retinyl ester acylhydrolase, 11-cis-retinol forming
R08389  phosphatidylcholine:retinol O-acyltransferase
R08390   
R08391   
R08392   
R11952  all-trans-retinol,reduced adrenodoxin:oxygen 3,4-oxidoreductase
Compound
C00376  Retinal
C00473  Retinol
C00777  Retinoate
C00778  Rhodopsin
C00899  11-cis-Retinol
C02075  Retinyl ester
C02094  beta-Carotene
C02110  11-cis-Retinal
C02588  Retinyl palmitate
C03455  11-cis-Retinyl palmitate
C05914  Bathorhodopsin
C05915  Lumirhodopsin
C05916  Metarhodopsin
C05917  Iodopsin
C11061  all-trans-Retinoyl-beta-glucuronide
C15492  all-trans-13,14-Dihydroretinol
C15493  9-cis-Retinoic acid
C16677  all-trans-4-Hydroxyretinoic acid
C16678  all-trans-4-Oxoretinoic acid
C16679  all-trans-18-Hydroxyretinoic acid
C16680  all-trans-5,6-Epoxyretinoic acid
C16681  9-cis-Retinal
C16682  9-cis-Retinol
C16683  4-Oxoretinol
C21797  all-trans-3,4-Didehydroretinol
Reference
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225
Reference
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003
Reference
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341
Reference
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242
Reference
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200
Related
pathway
rn00906  Carotenoid biosynthesis
KO pathway
ko00830   

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