Entry
Name
Biosynthesis of type II polyketide products
Class
Metabolism; Metabolism of terpenoids and polyketides
Pathway map
rn01057 Biosynthesis of type II polyketide products
Ortholog table
Module
M00779 Dihydrokalafungin biosynthesis, octaketide => dihydrokalafungin [PATH:rn01057 ]
M00780 Tetracycline/oxytetracycline biosynthesis, pretetramide => tetracycline/oxytetracycline [PATH:rn01057 ]
M00781 Nogalavinone/aklavinone biosynthesis, deoxynogalonate/deoxyaklanonate => nogalavinone/aklavinone [PATH:rn01057 ]
M00782 Mithramycin biosynthesis, 4-demethylpremithramycinone => mithramycin [PATH:rn01057 ]
M00783 Tetracenomycin C/8-demethyltetracenomycin C biosynthesis, tetracenomycin F2 => tetracenomycin C/8-demethyltetracenomycin C [PATH:rn01057 ]
M00784 Elloramycin biosynthesis, 8-demethyltetracenomycin C => elloramycin A [PATH:rn01057 ]
M00823 Chlortetracycline biosynthesis, pretetramide => chlortetracycline [PATH:rn01057 ]
Reaction
R04060 anhydrotetracycline,NADPH:oxygen oxidoreductase (6-hydroxylating)
R05459 tetracycline:coenzyme-F420 oxidoreductase
R05462 4-hydroxy-6-methylpretetramide,NADPH:oxygen oxidoreductase (12a-hydroxylating)
R05463 6-methylpretetramide,NADPH:oxygen oxidoreductase (4-hydroxylating)
R05705 FMNH2:NAD+ oxidoreductase
R06660 dTDP-D-olivose:compound-100-1 O-beta-D-olivosyltransferase
R06668 dTDP-D-olivose:urdamycin-G D-olivosyltransferase
R06675 S-adenosyl-L-methionine:nogalonic-acid O-methyltransferase
R06676 auraviketone lyase (decyclizing)
R06677 auramycinone:NADP+ 7-oxidoreductase
R06679 12-deoxyaklanonic-acid:oxygen oxidoreductase
R06680 S-adenosyl-L-methionine:aklanonate O-methyltransferase
R06681 aklaviketone lyase (ring-opening)
R06682 aklavinone:NADP+ 7-oxidoreductase
R06683 aklavinone,NADPH:oxygen oxidoreductase (12-hydroxylating)
R06684 dTDP-beta-L-daunosamine:epsilon-rhodomycinone beta-L-daunosaminyltransferase
R06687 S-adenosyl-L-methionine:13-deoxycarminomycin 4-O-methyltransferase
R06688 13-deoxydaunorubicin,NADPH:oxygen oxidoreductase (13-hydroxylating)
R06689 13-dihydrodaunorubicin,NADPH:oxygen oxidoreductase (13-hydroxylating)
R06690 daunorubicin,NADPH:oxygen oxidoreductase (hydroxylating)
R06691 13-deoxycarminomycin,NADPH:oxygen oxidoreductase (13-hydroxylating)
R06692 13-dihydrocarminomycin,NADPH:oxygen oxidoreductase
R06693 S-adenosyl-L-methionine:carminomycin 4-O-methyltransferase
R06699 tetracenomycin-F2 hydro-lyase (tetracenomycin-F1-forming)
R06700 tetracenomycin-F1:oxygen C5-monooxygenase
R06703 S-adenosyl-L-methionine:tetracenomycin-E O-methyltransferase
R06704 tetracenomycin-A2,NADPH:oxygen oxidoreductase (tetracenomycin-C-forming)
R06713 S-adenosyl-L-methionine:tetracenomycin-B3 O-methyltransferase
R06715 S-adenosyl-L-methionine:4-demethylpremithramycinone O-methyltransferase
R06716 dTDP-D-olivose:premithramycinone D-olivosyltransferase
R06717 dTDP-D-oliose:premithramycin-A1 D-oliosyltransferase
R06719 S-adenosyl-L-methionine:premithramycin-A3' C-methyltransferase
R09189 S-adenosyl-L-methionine:pretetramid C-methyltransferase
R09190 6-methylpretetramide,NADPH:oxygen oxidoreductase (4,12a-hydroxylating)
R09191 S-adenosyl-L-methionine:4-amino-anhydrotetracycline N-methyltransferase
R09192 oxytetracycline:coenzyme-F420 oxidoreductase
R09198 5a,11a-dehydrotetracycline,NADPH:oxygen oxidoreductase (5-hydroxylating)
R09313 dihydrokalafungin-dihydroquinone,FMNH2:oxygen oxidoreductase (hydroxylating)
R09327 deoxynogalonate:oxygen oxidoreductase
R09328 nogalaviketone lyase (ring-opening)
R09329 nogalavinone:NADP+ 7-oxidoreductase
R09331 dTDP-beta-L-rhodosamine:aklavinone 7-alpha-L-rhodosaminyltransferase
R09332 dTDP-2-deoxy-beta-L-fucose:aclacinomycin-T 2-deoxy-alpha-L-fucosyltransferase
R09334 aclacinomycin N:oxygen oxidoreductase
R09335 aclacinomycin A:oxygen oxidoreductase
R09337 epsilon-rhodomycin-T acylhydrolase
R09345 dTDP-D-olivose:UWM6 9-C-beta-D-olivosyltransferase
R09351 dTDP-D-olivose:premithramycin-A3 D-olivosyltransferase
R09352 dTDP-D-olivose:3A-deolivosylpremithramycin-B D-olivosyltransferase
R09353 premithramycin-B,NADPH:oxygen oxidoreductase
R10545 aclacinomycin T acylhydrolase
R10954 tetracenomycin-B2,NADPH:oxygen oxidoreductase (8-demethyltetracenomycin-C-forming)
R10955 dTDP-beta-L-rhamnose:8-demethyltetracenomycin-C alpha-L-rhamnosyltransferase
R10956 S-adenosyl-L-methionine:8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase
R10957 S-adenosyl-L-methionine:8-demethyl-8-(2-methoxy-alpha-L-rhamnosyl)tetracenomycin-C 3'-O-methyltransferase
R10958 S-adenosyl-L-methionine:8-demethyl-8-(2,3-di-O-methoxy-alpha-L-rhamnosyl)tetracenomycin-C 4'-O-methyltransferase
R10959 S-adenosyl-L-methionine:8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)tetracenomycin-C O-methyltransferase
R11478 tetracycline:FADH2 oxidoreductase (7-halogenating)
Compound
C03206 5a,11a-Dehydrotetracycline
C06627 4-Keto-anhydrotetracycline
C06628 4-Hydroxy-6-methylpretetramide
C06654 4-Amino-anhydrotetracycline
C12373 Tetracenomycin F1 methylester
C12374 Decarboxytetracenomycin F1
C12375 Tetracenomycin D3 methylester
C12379 8-Demethyltetracenomycin C
C12382 4-Demethylpremithramycinone
C12400 19-Hydroxy-8-O-methyltetrangulol
C12427 10-Carboxy-13-deoxycarminomycin
C12433 (13S)-13-Dihydrodaunorubicin
C12435 6-Deoxydihydrokalafungin
C18293 Nonaketamide monocyclic intermediate
C18294 Nonaketamide tricyclic intermediate
C18296 5a,11a-Dehydrooxytetracycline
C18329 7,9,12-Octaketide intermediate 3
C18332 7,9,12-Decaketide intermediate 3
C18335 7,9,12-Decaketide intermediate 6
C18336 7,12-Decaketide intermediate 1
C18337 9,14-Decaketide intermediate 1
C18353 Octaketide bicyclic intermediate
C18360 Dihydrokalafungin dihydroquinone form
C18641 15-Demethoxy-epsilon-rhodomycin
C18681 C1'-C9-Glycosylated UWM6
C18709 Decaketide tricyclic intermediate
C18710 3A-Deolivosylpremithramycin B
C18778 8-D-Olivosyl-landomycin
C20689 15-Demethylaclacinomycin T
C20974 8-Demethyl-8-alpha-L-rhamnosyltetracenomycin C
C20975 8-Demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)tetracenomycin C
C20976 8-Demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)tetracenomycin C
C20977 8-Demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)tetracenomycin C
Reference
Authors
Taguchi T, Okamoto S, Lezhava A, Li A, Ochi K, Ebizuka Y, Ichinose K
Title
Possible involvement of ActVI-ORFA in transcriptional regulation of actVI tailoring-step genes for actinorhodin biosynthesis.
Journal
Reference
Authors
Ichinose K, Ozawa M, Itou K, Kunieda K, Ebizuka Y
Title
Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequinone gene clusters.
Journal
Reference
Authors
Li A, Itoh T, Taguchi T, Xiang T, Ebizuka Y, Ichinose K
Title
Functional studies on a ketoreductase gene from Streptomyces sp. AM-7161 to control the stereochemistry in medermycin biosynthesis.
Journal
Reference
Authors
Ichinose K, Bedford DJ, Tornus D, Bechthold A, Bibb MJ, Revill WP, Floss HG, Hopwood DA
Title
The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22: sequence analysis and expression in a heterologous host.
Journal
Reference
Authors
Hopwood DA
Title
Genetic Contributions to Understanding Polyketide Synthases.
Journal
Reference
Authors
Fernandez-Moreno MA, Martinez E, Caballero JL, Ichinose K, Hopwood DA, Malpartida F
Title
DNA sequence and functions of the actVI region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor A3(2).
Journal
J Biol Chem 269:24854-63 (1994)
Reference
Authors
Itoh T, Taguchi T, Kimberley MR, Booker-Milburn KI, Stephenson GR, Ebizuka Y, Ichinose K
Title
Actinorhodin biosynthesis: structural requirements for post-PKS tailoring intermediates revealed by functional analysis of ActVI-ORF1 reductase.
Journal
Reference
Authors
Ichinose K, Taguchi T, Bedford DJ, Ebizuka Y, Hopwood DA
Title
Functional complementation of pyran ring formation in actinorhodin biosynthesis in Streptomyces coelicolor A3(2) by ketoreductase genes for granaticin biosynthesis.
Journal
Reference
Authors
Taguchi T, Ebizuka Y, Hopwood DA, Ichinose K
Title
A new mode of stereochemical control revealed by analysis of the biosynthesis of dihydrogranaticin in Streptomyces violaceoruber Tu22.
Journal
Reference
Authors
Taguchi T, Kunieda K, Takeda-Shitaka M, Takaya D, Kawano N, Kimberley MR, Booker-Milburn KI, Stephenson GR, Umeyama H, Ebizuka Y, Ichinose K
Title
Remarkably different structures and reaction mechanisms of ketoreductases for the opposite stereochemical control in the biosynthesis of BIQ antibiotics.
Journal
Reference
Authors
Okamoto S, Taguchi T, Ochi K, Ichinose K
Title
Biosynthesis of actinorhodin and related antibiotics: discovery of alternative routes for quinone formation encoded in the act gene cluster.
Journal
Reference
Authors
Valton J, Mathevon C, Fontecave M, Niviere V, Ballou DP
Title
Mechanism and regulation of the Two-component FMN-dependent monooxygenase ActVA-ActVB from Streptomyces coelicolor.
Journal
Reference
Authors
Valton J, Fontecave M, Douki T, Kendrew SG, Niviere V
Title
An aromatic hydroxylation reaction catalyzed by a two-component FMN-dependent Monooxygenase. The ActVA-ActVB system from Streptomyces coelicolor.
Journal
Reference
Authors
Valton J, Filisetti L, Fontecave M, Niviere V
Title
A two-component flavin-dependent monooxygenase involved in actinorhodin biosynthesis in Streptomyces coelicolor.
Journal
Reference
Authors
Ellis HR
Title
The FMN-dependent two-component monooxygenase systems.
Journal
Reference
Authors
Filisetti L, Fontecave M, Niviere V
Title
Mechanism and substrate specificity of the flavin reductase ActVB from Streptomyces coelicolor.
Journal
Reference
Authors
Kendrew SG, Hopwood DA, Marsh EN
Title
Identification of a monooxygenase from Streptomyces coelicolor A3(2) involved in biosynthesis of actinorhodin: purification and characterization of the recombinant enzyme.
Journal
Reference
Authors
Sciara G, Kendrew SG, Miele AE, Marsh NG, Federici L, Malatesta F, Schimperna G, Savino C, Vallone B
Title
The structure of ActVA-Orf6, a novel type of monooxygenase involved in actinorhodin biosynthesis.
Journal
Reference
Authors
Fetzner S, Steiner RA
Title
Cofactor-independent oxidases and oxygenases.
Journal
Reference
Authors
Krohn K (ed).
Title
Anthracycline Chemistry and Biology I : Biological Occurence and Biosynthesis, Synthesis and Chemistry
Journal
Topics in Current Chemistry 282 (2008)
Reference
Authors
Torkkell S, Kunnari T, Palmu K, Mantsala P, Hakala J, Ylihonko K
Title
The entire nogalamycin biosynthetic gene cluster of Streptomyces nogalater: characterization of a 20-kb DNA region and generation of hybrid structures.
Journal
Reference
Authors
Grocholski T, Koskiniemi H, Lindqvist Y, Mantsala P, Niemi J, Schneider G
Title
Crystal structure of the cofactor-independent monooxygenase SnoaB from Streptomyces nogalater: implications for the reaction mechanism.
Journal
Reference
Authors
Koskiniemi H, Grocholski T, Schneider G, Niemi J
Title
Expression, purification and crystallization of the cofactor-independent monooxygenase SnoaB from the nogalamycin biosynthetic pathway.
Journal
Reference
Authors
Chung JY, Fujii I, Harada S, Sankawa U, Ebizuka Y
Title
Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.
Journal
Reference
Authors
Dickens ML, Ye J, Strohl WR
Title
Analysis of clustered genes encoding both early and late steps in daunomycin biosynthesis by Streptomyces sp. strain C5.
Journal
Reference
Authors
Torkkell S, Kunnari T, Palmu K, Hakala J, Mantsala P, Ylihonko K
Title
Identification of a cyclase gene dictating the C-9 stereochemistry of anthracyclines from Streptomyces nogalater.
Journal
Reference
Authors
Sultana A, Kallio P, Jansson A, Wang JS, Niemi J, Mantsala P, Schneider G
Title
Structure of the polyketide cyclase SnoaL reveals a novel mechanism for enzymatic aldol condensation.
Journal
Reference
Authors
Kallio P, Sultana A, Niemi J, Mantsala P, Schneider G
Title
Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity.
Journal
Reference
Authors
Dickens ML, Ye J, Strohl WR
Title
Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5.
Journal
Reference
Authors
Leimkuhler C, Fridman M, Lupoli T, Walker S, Walsh CT, Kahne D
Title
Characterization of rhodosaminyl transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of aclacinomycin A.
Journal
Reference
Authors
Lu W, Leimkuhler C, Gatto GJ Jr, Kruger RG, Oberthur M, Kahne D, Walsh CT
Title
AknT is an activating protein for the glycosyltransferase AknS in L-aminodeoxysugar transfer to the aglycone of aclacinomycin A.
Journal
Reference
Authors
Lu W, Leimkuhler C, Oberthur M, Kahne D, Walsh CT
Title
AknK is an L-2-deoxyfucosyltransferase in the biosynthesis of the anthracycline aclacinomycin A.
Journal
Reference
Authors
Alexeev I, Sultana A, Mantsala P, Niemi J, Schneider G
Title
Aclacinomycin oxidoreductase (AknOx) from the biosynthetic pathway of the antibiotic aclacinomycin is an unusual flavoenzyme with a dual active site.
Journal
Reference
Authors
Lindqvist Y, Koskiniemi H, Jansson A, Sandalova T, Schnell R, Liu Z, Mantsala P, Niemi J, Schneider G
Title
Structural basis for substrate recognition and specificity in aklavinone-11-hydroxylase from rhodomycin biosynthesis.
Journal
Reference
Authors
Malla S, Niraula NP, Singh B, Liou K, Sohng JK
Title
Limitations in doxorubicin production from Streptomyces peucetius.
Journal
Reference
Authors
Otten SL, Liu X, Ferguson J, Hutchinson CR
Title
Cloning and characterization of the Streptomyces peucetius dnrQS genes encoding a daunosamine biosynthesis enzyme and a glycosyl transferase involved in daunorubicin biosynthesis.
Journal
Reference
Authors
Malla S, Niraula NP, Liou K, Sohng JK
Title
Enhancement of doxorubicin production by expression of structural sugar biosynthesis and glycosyltransferase genes in Streptomyces peucetius.
Journal
Reference
Authors
Dickens ML, Priestley ND, Strohl WR
Title
In vivo and in vitro bioconversion of epsilon-rhodomycinone glycoside to doxorubicin: functions of DauP, DauK, and DoxA.
Journal
Reference
Authors
Lomovskaya N, Otten SL, Doi-Katayama Y, Fonstein L, Liu XC, Takatsu T, Inventi-Solari A, Filippini S, Torti F, Colombo AL, Hutchinson CR
Title
Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.
Journal
Reference
Authors
Jansson A, Koskiniemi H, Erola A, Wang J, Mantsala P, Schneider G, Niemi J
Title
Aclacinomycin 10-hydroxylase is a novel substrate-assisted hydroxylase requiring S-adenosyl-L-methionine as cofactor.
Journal
Reference
Authors
Wohlert SE, Wendt-Pienkowski E, Bao W, Hutchinson CR
Title
Production of aromatic minimal polyketides by the daunorubicin polyketide synthase genes reveals the incompatibility of the heterologous DpsY and JadI cyclases.
Journal
Reference
Authors
Zhou H, Li Y, Tang Y
Title
Cyclization of aromatic polyketides from bacteria and fungi.
Journal
Reference
Authors
Hertweck C, Luzhetskyy A, Rebets Y, Bechthold A
Title
Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork.
Journal
Reference
Authors
Chen Y, Fan K, He Y, Xu X, Peng Y, Yu T, Jia C, Yang K
Title
Characterization of JadH as an FAD- and NAD(P)H-dependent bifunctional hydroxylase/dehydrase in jadomycin biosynthesis.
Journal
Reference
Authors
Rix U, Wang C, Chen Y, Lipata FM, Remsing Rix LL, Greenwell LM, Vining LC, Yang K, Rohr J
Title
The oxidative ring cleavage in jadomycin biosynthesis: a multistep oxygenation cascade in a biosynthetic black box.
Journal
Reference
Authors
Chen YH, Wang CC, Greenwell L, Rix U, Hoffmeister D, Vining LC, Rohr J, Yang KQ
Title
Functional analyses of oxygenases in jadomycin biosynthesis and identification of JadH as a bifunctional oxygenase/dehydrase.
Journal
Reference
Authors
Borissow CN, Graham CL, Syvitski RT, Reid TR, Blay J, Jakeman DL
Title
Stereochemical integrity of oxazolone ring-containing jadomycins.
Journal
Reference
Authors
Mittler M, Bechthold A, Schulz GE
Title
Structure and action of the C-C bond-forming glycosyltransferase UrdGT2 involved in the biosynthesis of the antibiotic urdamycin.
Journal
Reference
Authors
Trefzer A, Hoffmeister D, Kunzel E, Stockert S, Weitnauer G, Westrich L, Rix U, Fuchser J, Bindseil KU, Rohr J, Bechthold A
Title
Function of glycosyltransferase genes involved in urdamycin A biosynthesis.
Journal
Reference
Authors
Hoffmeister D, Ichinose K, Bechthold A
Title
Two sequence elements of glycosyltransferases involved in urdamycin biosynthesis are responsible for substrate specificity and enzymatic activity.
Journal
Reference
Authors
Rohr J, Schonewolf M, Udvarnoki G, Eckardt K, Schumann G, Wagner C, Beale JM, Sorey SD.
Title
Investigations on the biosynthesis of the angucycline group antibiotics aquayamycin and the urdamycins A and B. Results from the structural analysis of novel blocked mutant products.
Journal
Reference
Authors
Zhu L, Ostash B, Rix U, Nur-E-Alam M, Mayers A, Luzhetskyy A, Mendez C, Salas JA, Bechthold A, Fedorenko V, Rohr J
Title
Identification of the function of gene lndM2 encoding a bifunctional oxygenase-reductase involved in the biosynthesis of the antitumor antibiotic landomycin E by Streptomyces globisporus 1912 supports the originally assigned structure for landomycinone.
Journal
Reference
Authors
Baig I, Kharel M, Kobylyanskyy A, Zhu L, Rebets Y, Ostash B, Luzhetskyy A, Bechthold A, Fedorenko VA, Rohr J
Title
On the acceptor substrate of C-glycosyltransferase UrdGT2: three prejadomycin C-Glycosides from an engineered mutant of Streptomyces globisporus 1912 DeltalndE(urdGT2).
Journal
Reference
Authors
Ostash B, Rix U, Rix LL, Liu T, Lombo F, Luzhetskyy A, Gromyko O, Wang C, Brana AF, Mendez C, Salas JA, Fedorenko V, Rohr J
Title
Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus.
Journal
Reference
Authors
Lombo F, Menendez N, Salas JA, Mendez C
Title
The aureolic acid family of antitumor compounds: structure, mode of action, biosynthesis, and novel derivatives.
Journal
Reference
Authors
Trefzer A, Blanco G, Remsing L, Kunzel E, Rix U, Lipata F, Brana AF, Mendez C, Rohr J, Bechthold A, Salas JA
Title
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.
Journal
Reference
Authors
Lozano MJ, Remsing LL, Quiros LM, Brana AF, Fernandez E, Sanchez C, Mendez C, Rohr J, Salas JA
Title
Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.
Journal
Reference
Authors
Blanco G, Fernandez E, Fernandez MJ, Brana AF, Weissbach U, Kunzel E, Rohr J, Mendez C, Salas JA
Title
Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.
Journal
Reference
Authors
Nur-e-Alam M, Mendez C, Salas JA, Rohr J
Title
Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.
Journal
Reference
Authors
Fernandez E, Weissbach U, Sanchez Reillo C, Brana AF, Mendez C, Rohr J, Salas JA
Title
Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.
Journal
Reference
Authors
Beam MP, Bosserman MA, Noinaj N, Wehenkel M, Rohr J
Title
Crystal structure of Baeyer-Villiger monooxygenase MtmOIV, the key enzyme of the mithramycin biosynthetic pathway .
Journal
Reference
Authors
Wang C, Gibson M, Rohr J, Oliveira MA
Title
Crystallization and X-ray diffraction properties of Baeyer-Villiger monooxygenase MtmOIV from the mithramycin biosynthetic pathway in Streptomyces argillaceus.
Journal
Reference
Authors
Rodriguez D, Quiros LM, Brana AF, Salas JA
Title
Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.
Journal
Reference
Authors
Hutchinson CR
Title
Biosynthetic Studies of Daunorubicin and Tetracenomycin C.
Journal
Reference
Authors
Summers RG, Wendt-Pienkowski E, Motamedi H, Hutchinson CR
Title
The tcmVI region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens encodes the tetracenomycin F1 monooxygenase, tetracenomycin F2 cyclase, and, most likely, a second cyclase.
Journal
Reference
Authors
Shen B, Hutchinson CR
Title
Tetracenomycin F2 cyclase: intramolecular aldol condensation in the biosynthesis of tetracenomycin C in Streptomyces glaucescens.
Journal
Reference
Authors
Shen B, Hutchinson CR
Title
Tetracenomycin F1 monooxygenase: oxidation of a naphthacenone to a naphthacenequinone in the biosynthesis of tetracenomycin C in Streptomyces glaucescens.
Journal
Reference
Authors
Summers RG, Wendt-Pienkowski E, Motamedi H, Hutchinson CR
Title
Nucleotide sequence of the tcmII-tcmIV region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens and evidence that the tcmN gene encodes a multifunctional cyclase-dehydratase-O-methyl transferase.
Journal
Reference
Authors
Ames BD, Korman TP, Zhang W, Smith P, Vu T, Tang Y, Tsai SC
Title
Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides.
Journal
Reference
Authors
Rafanan ER Jr, Hutchinson CR, Shen B
Title
Triple hydroxylation of tetracenomycin A2 to tetracenomycin C involving two molecules of O(2) and one molecule of H(2)O.
Journal
Reference
Authors
Ramos A, Lombo F, Brana AF, Rohr J, Mendez C, Salas JA
Title
Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster.
Journal
Reference
Authors
Patallo EP, Blanco G, Fischer C, Brana AF, Rohr J, Mendez C, Salas JA
Title
Deoxysugar methylation during biosynthesis of the antitumor polyketide elloramycin by Streptomyces olivaceus. Characterization of three methyltransferase genes.
Journal
Related pathway
rn01056 Biosynthesis of type II polyketide backbone
KO pathway