KEGG   PATHWAY: rno04010Help
Entry
rno04010                    Pathway                                

Name
MAPK signaling pathway - Rattus norvegicus (rat)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
rno04010  MAPK signaling pathway
rno04010

Ortholog table
Module
rno_M00687  MAPK (ERK1/2) signaling [PATH:rno04010]
rno_M00688  MAPK (JNK) signaling [PATH:rno04010]
rno_M00689  MAPK (p38) signaling [PATH:rno04010]
rno_M00690  MAPK (ERK5) signaling [PATH:rno04010]
Other DBs
BSID: 83440
GO: 0000165
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
25398  Cacna1a; calcium voltage-gated channel subunit alpha1 A [KO:K04344]
257648  Cacna1b; calcium voltage-gated channel subunit alpha1 B [KO:K04849]
24239  Cacna1c; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
29716  Cacna1d; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
54234  Cacna1e; calcium voltage-gated channel subunit alpha1 E [KO:K04852]
114493  Cacna1f; calcium voltage-gated channel subunit alpha1 F [KO:K04853]
29717  Cacna1g; calcium voltage-gated channel subunit alpha1 G [KO:K04854]
114862  Cacna1h; calcium voltage-gated channel subunit alpha1 H [KO:K04855]
56827  Cacna1i; calcium voltage-gated channel subunit alpha1 I [KO:K04856]
682930  Cacna1s; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
25399  Cacna2d1; calcium voltage-gated channel auxiliary subunit alpha2delta 1 [KO:K04858]
300992  Cacna2d2; calcium voltage-gated channel auxiliary subunit alpha2delta 2 [KO:K04859]
306243  Cacna2d3; calcium voltage-gated channel auxiliary subunit alpha2delta 3 [KO:K04860]
312668  Cacna2d4; calcium voltage-gated channel auxiliary subunit alpha2delta 4 [KO:K04861]
50688  Cacnb1; calcium voltage-gated channel auxiliary subunit beta 1 [KO:K04862]
116600  Cacnb2; calcium voltage-gated channel auxiliary subunit beta 2 [KO:K04863]
25297  Cacnb3; calcium voltage-gated channel auxiliary subunit beta 3 [KO:K04864]
58942  Cacnb4; calcium voltage-gated channel auxiliary subunit beta 4 [KO:K04865]
29658  Cacng1; calcium voltage-gated channel auxiliary subunit gamma 1 [KO:K04866]
84347  Cacng2; calcium voltage-gated channel auxiliary subunit gamma 2 [KO:K04867]
140724  Cacng3; calcium voltage-gated channel auxiliary subunit gamma 3 [KO:K04868]
140725  Cacng4; calcium voltage-gated channel auxiliary subunit gamma 4 [KO:K04869]
140726  Cacng5; calcium voltage-gated channel auxiliary subunit gamma 5 [KO:K04870]
140727  Cacng6; calcium voltage-gated channel auxiliary subunit gamma 6 [KO:K04871]
140728  Cacng7; calcium voltage-gated channel auxiliary subunit gamma 7 [KO:K04872]
140729  Cacng8; calcium voltage-gated channel auxiliary subunit gamma 8 [KO:K04873]
25636  Prkaca; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
293508  Prkacb; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
24680  Prkca; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
25023  Prkcb; protein kinase C, beta [KO:K19662] [EC:2.7.11.13]
24681  Prkcg; protein kinase C, gamma [KO:K19663] [EC:2.7.11.13]
81663  Gna12; G protein subunit alpha 12 [KO:K04346]
114120  Gng12; G protein subunit gamma 12 [KO:K04347]
685513  similar to Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-12 subunit precursor [KO:K04347]
24674  Ppp3ca; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
24675  Ppp3cb; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
171378  Ppp3cc; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
29748  Ppp3r1; protein phosphatase 3, regulatory subunit B, alpha [KO:K06268]
29749  Ppp3r2; protein phosphatase 3, regulatory subunit B, beta [KO:K06268]
192213  Rasgrf1; RAS protein-specific guanine nucleotide-releasing factor 1 [KO:K04349]
114513  Rasgrf2; RAS protein-specific guanine nucleotide-releasing factor 2 [KO:K12326]
29434  Rasgrp1; RAS guanyl releasing protein 1 [KO:K04350]
361714  Rasgrp2; RAS guanyl releasing protein 2 [KO:K12361]
313874  Rasgrp3; RAS guanyl releasing protein 3 [KO:K12362]
170668  Rasgrp4; RAS guanyl releasing protein 4 [KO:K12363]
310533  Rapgef2; Rap guanine nucleotide exchange factor 2 [KO:K08018]
24592  Nf1; neurofibromin 1 [KO:K08052]
25676  Rasa1; RAS p21 protein activator 1 [KO:K04352]
25597  Rasa2; RAS p21 protein activator 2 [KO:K08053]
295347  Rap1a; RAP1A, member of RAS oncogene family [KO:K04353]
171337  Rap1b; RAP1B, member of RAS oncogene family [KO:K07836]
25313  Egf; epidermal growth factor [KO:K04357]
24827  Tgfa; transforming growth factor alpha [KO:K08774]
59325  Ereg; epiregulin [KO:K09784]
29183  Areg; amphiregulin [KO:K09782]
25317  Fgf1; fibroblast growth factor 1 [KO:K18496]
54250  Fgf2; fibroblast growth factor 2 [KO:K18497]
170633  Fgf3; fibroblast growth factor 3 [KO:K04358]
116499  Fgf4; fibroblast growth factor 4 [KO:K04358]
60662  Fgf5; fibroblast growth factor 5 [KO:K04358]
170700  Fgf6; fibroblast growth factor 6 [KO:K04358]
29348  Fgf7; fibroblast growth factor 7 [KO:K04358]
29349  Fgf8; fibroblast growth factor 8 [KO:K04358]
25444  Fgf9; fibroblast growth factor 9 [KO:K04358]
25443  Fgf10; fibroblast growth factor 10 [KO:K04358]
60464  Fgf16; fibroblast growth factor 16 [KO:K04358]
29368  Fgf17; fibroblast growth factor 17 [KO:K04358]
29369  Fgf18; fibroblast growth factor 18 [KO:K04358]
66017  Fgf20; fibroblast growth factor 20 [KO:K04358]
170579  Fgf22; fibroblast growth factor 22 [KO:K04358]
170582  Fgf19; fibroblast growth factor 19 [KO:K22603]
170580  Fgf21; fibroblast growth factor 21 [KO:K22429]
170583  Fgf23; fibroblast growth factor 23 [KO:K22428]
310738  Ngf; nerve growth factor [KO:K02582]
24225  Bdnf; brain-derived neurotrophic factor [KO:K04355]
81737  Ntf3; neurotrophin 3 [KO:K04356]
25730  Ntf4; neurotrophin 4 [KO:K12457]
24506  Ins2; insulin 2 [KO:K04526]
24505  Ins1; insulin 1 [KO:K04526]
24482  Igf1; insulin-like growth factor 1 [KO:K05459]
24483  Igf2; insulin-like growth factor 2 [KO:K13769]
25266  Pdgfa; platelet derived growth factor subunit A [KO:K04359]
24628  Pdgfb; platelet derived growth factor subunit B [KO:K17386]
79429  Pdgfc; platelet derived growth factor C [KO:K05450]
66018  Pdgfd; platelet derived growth factor D [KO:K05450]
78965  Csf1; colony stimulating factor 1 [KO:K05453]
60427  Kitlg; KIT ligand [KO:K05461]
103691134  Flt3lg; fms-related tyrosine kinase 3 ligand [KO:K05454]
83785  Vegfa; vascular endothelial growth factor A [KO:K05448]
89811  Vegfb; vascular endothelial growth factor B [KO:K16858]
94203  Pgf; placental growth factor [KO:K16859]
114111  Vegfc; vascular endothelial growth factor C [KO:K05449]
360457  Vegfd; vascular endothelial growth factor D [KO:K05449]
24446  Hgf; hepatocyte growth factor [KO:K05460]
89807  Angpt1; angiopoietin 1 [KO:K05465]
89805  Angpt2; angiopoietin 2 [KO:K05466]
296269  Angpt4; angiopoietin 4 [KO:K05467]
94268  Efna1; ephrin A1 [KO:K05462]
116683  Efna5; ephrin A5 [KO:K05462]
310643  Efna4; ephrin A4 [KO:K05462]
84358  Efna2; ephrin A2 [KO:K05462]
170901  Efna3; ephrin A3 [KO:K05462]
24329  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
24337  Erbb2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
29496  Erbb3; erb-b2 receptor tyrosine kinase 3 [KO:K05084] [EC:2.7.10.1]
59323  Erbb4; erb-b2 receptor tyrosine kinase 4 [KO:K05085] [EC:2.7.10.1]
79114  Fgfr1; Fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
25022  Fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
84489  Fgfr3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
25114  Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
24596  Ngfr; nerve growth factor receptor [KO:K02583]
59109  Ntrk1; neurotrophic receptor tyrosine kinase 1 [KO:K03176] [EC:2.7.10.1]
25054  Ntrk2; neurotrophic receptor tyrosine kinase 2 [KO:K04360] [EC:2.7.10.1]
24954  Insr; insulin receptor [KO:K04527] [EC:2.7.10.1]
25718  Igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
25267  Pdgfra; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
24629  Pdgfrb; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
307403  Csf1r; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
64030  Kit; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
140635  Flt3; fms-related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
54251  Flt1; FMS-related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
114110  Flt4; fms-related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
25589  Kdr; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
24553  Met; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
89804  Tek; TEK receptor tyrosine kinase [KO:K05121] [EC:2.7.10.1]
366492  Epha2; Eph receptor A2 [KO:K05103] [EC:2.7.10.1]
81504  Grb2; growth factor receptor bound protein 2 [KO:K04364]
85384  Sos2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
313845  Sos1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
293621  Hras; Harvey rat sarcoma virus oncogene [KO:K02833]
24525  Kras; KRAS proto-oncogene, GTPase [KO:K07827]
24605  Nras; neuroblastoma RAS viral oncogene homolog [KO:K07828]
361568  Rras; related RAS viral (r-ras) oncogene homolog [KO:K07829]
365355  Rras2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
25482  Mras; muscle RAS oncogene homolog [KO:K07831]
64363  Araf; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
114486  Braf; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
24703  Raf1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
170851  Map2k1; mitogen activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
58960  Map2k2; mitogen activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
362045  Lamtor3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370]
116590  Mapk1; mitogen activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
50689  Mapk3; mitogen activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
299618  Mknk2; MAP kinase-interacting serine/threonine kinase 2 [KO:K04372] [EC:2.7.11.1]
500526  Mknk1; MAP kinase-interacting serine/threonine kinase 1 [KO:K04372] [EC:2.7.11.1]
81771  Rps6ka1; ribosomal protein S6 kinase A1 [KO:K04373] [EC:2.7.11.1]
117269  Rps6ka2; ribosomal protein S6 kinase A2 [KO:K04373] [EC:2.7.11.1]
501560  Rps6ka3; ribosomal protein S6 kinase A3 [KO:K04373] [EC:2.7.11.1]
317203  Rps6ka6; ribosomal protein S6 kinase A6 [KO:K04373] [EC:2.7.11.1]
79255  Atf4; activating transcription factor 4 [KO:K04374]
314436  Elk1; ELK1, ETS transcription factor [KO:K04375]
304786  Elk4; ELK4, ETS transcription factor [KO:K04376]
24577  Myc; myelocytomatosis oncogene [KO:K04377]
501099  Srf; serum response factor [KO:K04378]
314322  Fos; FBJ osteosarcoma oncogene [KO:K04379]
29477  Mapt; microtubule-associated protein tau [KO:K04380]
29332  Stmn1; stathmin 1 [KO:K04381]
296091  Pla2g4e; phospholipase A2, group IVE [KO:K16342] [EC:3.1.1.4]
24653  Pla2g4a; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
311341  Pla2g4b; phospholipase A2 group IVB [KO:K16342] [EC:3.1.1.4]
691813  similar to phospholipase A2, group IVC (cytosolic, calcium-independent) [KO:K16342] [EC:3.1.1.4]
691905  Pla2g4d; phospholipase A2 group IVD [KO:K16342] [EC:3.1.1.4]
691907  Pla2g4f; phospholipase A2, group IVF [KO:K16342] [EC:3.1.1.4]
691810  Pla2g4c; phospholipase A2, group IVC (cytosolic, calcium-independent) [KO:K16342] [EC:3.1.1.4]
24835  Tnf; tumor necrosis factor [KO:K03156]
103694380  tumor necrosis factor [KO:K03156]
24493  Il1a; interleukin 1 alpha [KO:K04383]
24494  Il1b; interleukin 1 beta [KO:K04519]
59086  Tgfb1; transforming growth factor, beta 1 [KO:K13375]
81809  Tgfb2; transforming growth factor, beta 2 [KO:K13376]
25717  Tgfb3; transforming growth factor, beta 3 [KO:K13377]
25625  Tnfrsf1a; TNF receptor superfamily member 1A [KO:K03158]
25663  Il1r1; interleukin 1 receptor type 1 [KO:K04386]
25466  Il1rap; interleukin 1 receptor accessory protein [KO:K04723]
29591  Tgfbr1; transforming growth factor, beta receptor 1 [KO:K04674] [EC:2.7.11.30]
81810  Tgfbr2; transforming growth factor, beta receptor 2 [KO:K04388] [EC:2.7.11.30]
25385  Faslg; Fas ligand [KO:K04389]
246097  Fas; Fas cell surface death receptor [KO:K04390]
60350  Cd14; CD14 molecule [KO:K04391]
363875  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
366957  Rac2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
64465  Cdc42; cell division cycle 42 [KO:K04393]
246756  Tradd; TNFRSF1A-associated via death domain [KO:K03171]
25402  Casp3; caspase 3 [KO:K02187] [EC:3.4.22.56]
311786  Traf2; Tnf receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
140926  Daxx; death-domain associated protein [KO:K02308]
301059  Myd88; myeloid differentiation primary response 88 [KO:K04729]
363520  Irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
300177  Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
311245  Traf6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
25112  Gadd45a; growth arrest and DNA-damage-inducible, alpha [KO:K04402]
291005  Gadd45g; growth arrest and DNA-damage-inducible, gamma [KO:K04402]
299626  Gadd45b; growth arrest and DNA-damage-inducible, beta [KO:K04402]
315139  Tab1; TGF-beta activated kinase 1/MAP3K7 binding protein 1 [KO:K04403]
308267  Tab2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
300447  Ecsit; ECSIT signalling integrator [KO:K04405]
170920  Map4k3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
301363  Map4k4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
292763  Map4k1; mitogen activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
29431  Pak1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
29432  Pak2; p21 protein (Cdc42/Rac)-activated kinase 2 [KO:K04410] [EC:2.7.11.1]
100910732  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
311622  Stk4; serine/threonine kinase 4 [KO:K04411]
65189  Stk3; serine/threonine kinase 3 [KO:K04412]
293694  Map4k2; mitogen activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
116596  Map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
116667  Map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
100912399  mitogen-activated protein kinase kinase kinase 1-like [KO:K04416] [EC:2.7.11.25]
309168  Map3k11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
171492  Map3k2; mitogen activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
303604  Map3k3; mitogen activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
303823  Map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
25579  Map3k12; mitogen activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
311743  Map3k20; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
313022  Map3k6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
365057  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
313121  Map3k7; mitogen activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
100910771  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
308106  Map3k4; mitogen activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
64666  Taok2; TAO kinase 2 [KO:K04429] [EC:2.7.11.1]
286993  Taok1; TAO kinase 1 [KO:K04429] [EC:2.7.11.1]
304530  Taok3; TAO kinase 3 [KO:K04429] [EC:2.7.11.1]
287398  Map2k4; mitogen activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
363855  Map2k7; mitogen activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
303200  Map2k3; mitogen activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
108348082  dual specificity mitogen-activated protein kinase kinase 3-like [KO:K04432] [EC:2.7.12.2]
114495  Map2k6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
116457  Mapk8ip1; mitogen-activated protein kinase 8 interacting protein 1 [KO:K04434]
315220  Mapk8ip2; mitogen-activated protein kinase 8 interacting protein 2 [KO:K04435]
302983  Mapk8ip3; mitogen-activated protein kinase 8 interacting protein 3 [KO:K04436]
306204  Flnb; filamin B [KO:K04437]
293860  Flna; filamin A [KO:K04437]
362332  Flnc; filamin C [KO:K04437]
54245  Crk; CRK proto-oncogene, adaptor protein [KO:K04438]
287942  Crkl; v-crk avian sarcoma virus CT10 oncogene homolog-like [KO:K04438]
100911248  crk-like protein-like [KO:K04438]
25387  Arrb1; arrestin, beta 1 [KO:K04439]
25388  Arrb2; arrestin, beta 2 [KO:K04439]
25272  Mapk10; mitogen activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
50658  Mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
116554  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
81649  Mapk14; mitogen activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
60352  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
29513  Mapk13; mitogen activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
689314  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
498183  Mapkapk5; mitogen-activated protein kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
289014  Mapkapk2; mitogen-activated protein kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
315994  Mapkapk3; mitogen-activated protein kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
314384  Rps6ka5; ribosomal protein S6 kinase A5 [KO:K04445] [EC:2.7.11.1]
361715  Rps6ka4; ribosomal protein S6 kinase A4 [KO:K16510] [EC:2.7.11.1]
171103  Cdc25b; cell division cycle 25B [KO:K05866] [EC:3.1.3.48]
100361818  Nfatc1; nuclear factor of activated T-cells 1 [KO:K04446]
361400  Nfatc3; nuclear factor of activated T-cells 3 [KO:K17333]
24516  Jun; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
24518  Jund; JunD proto-oncogene, AP-1 transcription factor subunit [KO:K04449]
81647  Atf2; activating transcription factor 2 [KO:K04450]
24842  Tp53; tumor protein p53 [KO:K04451]
29467  Ddit3; DNA-damage inducible transcript 3 [KO:K04452]
60661  Max; MYC associated factor X [KO:K04453]
499497  Mef2c; myocyte enhancer factor 2C [KO:K04454]
24471  Hspb1; heat shock protein family B (small) member 1 [KO:K04455]
24185  Akt1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
25233  Akt2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
29414  Akt3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
24666  Ppm1a; protein phosphatase, Mg2+/Mn2+ dependent, 1A [KO:K04457] [EC:3.1.3.16]
94202  Ptprr; protein tyrosine phosphatase, receptor type, R [KO:K04458] [EC:3.1.3.48]
29644  Ptpn5; protein tyrosine phosphatase, non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
246781  Ptpn7; protein tyrosine phosphatase, non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
114856  Dusp1; dual specificity phosphatase 1 [KO:K21278] [EC:3.1.3.48 3.1.3.16]
60587  Dusp4; dual specificity phosphatase 4 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
300980  Dusp7; dual specificity phosphatase 7 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
171109  Dusp5; dual specificity phosphatase 5 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
297682  Dusp16; dual specificity phosphatase 16 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
311406  Dusp2; dual specificity phosphatase 2 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
361679  Dusp8; dual specificity phosphatase 8 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
116663  Dusp6; dual specificity phosphatase 6 [KO:K21946] [EC:3.1.3.48 3.1.3.16]
293847  Dusp9; dual specificity phosphatase 9 [KO:K18498] [EC:3.1.3.48 3.1.3.16]
63995  Dusp10; dual specificity phosphatase 10 [KO:K20216] [EC:3.1.3.48 3.1.3.16]
498003  Dusp3; dual specificity phosphatase 3 [KO:K17614] [EC:3.1.3.48 3.1.3.16]
65179  Ppp5c; protein phosphatase 5, catalytic subunit [KO:K04460] [EC:3.1.3.16]
24667  Ppm1b; protein phosphatase, Mg2+/Mn2+ dependent, 1B [KO:K04461] [EC:3.1.3.16]
24468  Hspa8; heat shock protein family A (Hsp70) member 8 [KO:K03283]
24472  Hspa1a; heat shock 70kD protein 1A [KO:K03283]
60460  Hspa2; heat shock protein family A member 2 [KO:K03283]
294254  Hspa1b; heat shock 70kD protein 1B (mapped) [KO:K03283]
24963  Hspa1l; heat shock protein family A (Hsp70) member 1 like [KO:K03283]
294924  Mecom; MDS1 and EVI1 complex locus [KO:K04462]
29568  Map2k5; mitogen activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
114509  Mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
100912585  mitogen-activated protein kinase 7-like [KO:K04464] [EC:2.7.11.24]
79240  Nr4a1; nuclear receptor subfamily 4, group A, member 1 [KO:K04465]
360640  Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
309361  Chuk; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
84351  Ikbkb; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [KO:K07209] [EC:2.7.11.10]
309295  Ikbkg; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [KO:K07210]
497961  Nlk; nemo like kinase [KO:K04468] [EC:2.7.11.24]
81736  Nfkb1; nuclear factor kappa B subunit 1 [KO:K02580]
309452  Nfkb2; nuclear factor kappa B subunit 2 [KO:K04469]
309165  Rela; RELA proto-oncogene, NF-kB subunit [KO:K04735]
100360982  Relb; RELB proto-oncogene, NF-kB subunit [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
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Reference
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Docking interactions in the mitogen-activated protein kinase cascades.
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Reference
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
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Annu Rev Biochem 72:609-42 (2003)
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Reference
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  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
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  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Reference
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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Reference
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Reference
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
KO pathway
ko04010   

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