Entry
Name
Viral protein interaction with cytokine and cytokine receptor - Rattus norvegicus (rat)
Description
Viruses have evolved diverse mechanisms to evade detection and destruction by the immune system, including copying and repurposing host cytokine and cytokine receptor genes. Viral cytokines and cytokine receptors, together with a group of structurally unique, soluble, cytokine-binding or cytokine receptor-binding proteins, represent the three major molecular strategies for subversion and modulation of the host cytokine networks mainly in large DNA viruses. Viral cytokines and cytokine receptor homologs, including other binding proteins, may activate or inhibit cytokine signaling and possibly affect different aspects of immunity.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
rno04061 Viral protein interaction with cytokine and cytokine receptor
Ortholog table
Organism
Rattus norvegicus (rat) [GN:
rno ]
Gene
81780 Ccl5; C-C motif chemokine 5 precursor [KO:K12499 ]
25542 Ccl3; C-C motif chemokine 3 precursor [KO:K05408 ]
287562 Ccl12; C-C motif chemokine ligand 12 precursor [KO:K14624 ]
24770 Ccl2; C-C motif chemokine 2 precursor [KO:K14624 ]
29538 Ccl20; C-C motif chemokine 20 precursor [KO:K14625 ]
81503 Cxcl1; growth-regulated alpha protein precursor [KO:K05505 ]
60665 Cxcl6; C-X-C motif chemokine 5 precursor [KO:K05506 ]
245920 Cxcl10; C-X-C motif chemokine 10 precursor [KO:K12671 ]
305236 Cxcl11; C-X-C motif chemokine 11 precursor [KO:K12672 ]
498335 Cxcl13; C-X-C motif chemokine 13 isoform 2 precursor [KO:K10032 ]
24772 Cxcl12; stromal cell-derived factor 1 isoform beta precursor [KO:K10031 ]
306748 Cxcl14; C-X-C motif chemokine 14 precursor [KO:K10033 ]
301133 Tnfsf14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
246775 Tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
78965 Csf1; macrophage colony-stimulating factor 1 precursor [KO:K05453 ]
301088 Ccr1l1; C-C chemokine receptor 1-like protein 1 [KO:K04176 ]
287673 Ccr7; C-C chemokine receptor type 7 precursor [KO:K04182 ]
54258 Cxcr1; C-X-C chemokine receptor type 1 [KO:K04175 ]
29385 Cxcr2; C-X-C chemokine receptor type 2 [KO:K05050 ]
84475 Cxcr3; C-X-C chemokine receptor type 3 [KO:K04188 ]
29363 Cxcr5; C-X-C chemokine receptor type 5 [KO:K04190 ]
60628 Cxcr4; C-X-C chemokine receptor type 4 [KO:K04189 ]
117539 Il10ra; interleukin-10 receptor subunit alpha precursor [KO:K05134 ]
304091 Il10rb; interleukin-10 receptor subunit beta precursor [KO:K05135 ]
24499 Il6r; interleukin-6 receptor subunit alpha precursor [KO:K05055 ]
25205 Il6st; interleukin-6 receptor subunit beta precursor [KO:K05060 ]
25704 Il2ra; interleukin-2 receptor subunit alpha precursor [KO:K05068 ]
25746 Il2rb; interleukin-2 receptor subunit beta precursor [KO:K05069 ]
140924 Il2rg; cytokine receptor common subunit gamma precursor [KO:K05070 ]
301365 Il18r1; interleukin-18 receptor 1 precursor [KO:K05173 ]
373540 Il18rap; interleukin-18 receptor accessory protein precursor [KO:K05174 ]
308716 Il20ra; interleukin-20 receptor subunit alpha precursor [KO:K05136 ]
501043 Il20rb; interleukin-20 receptor subunit beta [KO:K05137 ]
362629 Il22ra1; interleukin-22 receptor subunit alpha-1 [KO:K05138 ]
25625 Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158 ]
156767 Tnfrsf1b; tumor necrosis factor receptor superfamily member 1B precursor [KO:K05141 ]
297604 Ltbr; tumor necrosis factor receptor superfamily member 3 precursor [KO:K03159 ]
366518 Tnfrsf14; tumor necrosis factor receptor superfamily member 14 precursor [KO:K05152 ]
Reference
Authors
Alcami A
Title
Viral mimicry of cytokines, chemokines and their receptors.
Journal
Reference
Authors
Pontejo SM, Murphy PM
Title
Chemokines encoded by herpesviruses.
Journal
Reference
Authors
de Munnik SM, Smit MJ, Leurs R, Vischer HF
Title
Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors.
Journal
Reference
Authors
Vischer HF, Siderius M, Leurs R, Smit MJ
Title
Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?
Journal
Reference
Authors
Smith CA, Smith TD, Smolak PJ, Friend D, Hagen H, Gerhart M, Park L, Pickup DJ, Torrance D, Mohler K, Schooley K, Goodwin RG
Title
Poxvirus genomes encode a secreted, soluble protein that preferentially inhibits beta chemokine activity yet lacks sequence homology to known chemokine receptors.
Journal
Reference
Authors
Isegawa Y, Ping Z, Nakano K, Sugimoto N, Yamanishi K
Title
Human herpesvirus 6 open reading frame U12 encodes a functional beta-chemokine receptor.
Journal
Reference
Authors
Damon I, Murphy PM, Moss B
Title
Broad spectrum chemokine antagonistic activity of a human poxvirus chemokine homolog.
Journal
Reference
Authors
Dewin DR, Catusse J, Gompels UA
Title
Identification and characterization of U83A viral chemokine, a broad and potent beta-chemokine agonist for human CCRs with unique selectivity and inhibition by spliced isoform.
Journal
Reference
Authors
Fitzsimons CP, Gompels UA, Verzijl D, Vischer HF, Mattick C, Leurs R, Smit MJ
Title
Chemokine-directed trafficking of receptor stimulus to different g proteins: selective inducible and constitutive signaling by human herpesvirus 6-encoded chemokine receptor U51.
Journal
Reference
Authors
Wang D, Bresnahan W, Shenk T
Title
Human cytomegalovirus encodes a highly specific RANTES decoy receptor.
Journal
Reference
Authors
Viejo-Borbolla A, Martinez-Martin N, Nel HJ, Rueda P, Martin R, Blanco S, Arenzana-Seisdedos F, Thelen M, Fallon PG, Alcami A
Title
Enhancement of chemokine function as an immunomodulatory strategy employed by human herpesviruses.
Journal
Reference
Authors
Alejo A, Ruiz-Arguello MB, Ho Y, Smith VP, Saraiva M, Alcami A
Title
A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virus.
Journal
Reference
Authors
Tadagaki K, Nakano K, Yamanishi K
Title
Human herpesvirus 7 open reading frames U12 and U51 encode functional beta-chemokine receptors.
Journal
Reference
Authors
Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG
Title
Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways.
Journal
Reference
Authors
Najarro P, Lee HJ, Fox J, Pease J, Smith GL
Title
Yaba-like disease virus protein 7L is a cell-surface receptor for chemokine CCL1.
Journal
Reference
Authors
Najarro P, Gubser C, Hollinshead M, Fox J, Pease J, Smith GL
Title
Yaba-like disease virus chemokine receptor 7L, a CCR8 orthologue.
Journal
Reference
Authors
Catusse J, Spinks J, Mattick C, Dyer A, Laing K, Fitzsimons C, Smit MJ, Gompels UA
Title
Immunomodulation by herpesvirus U51A chemokine receptor via CCL5 and FOG-2 down-regulation plus XCR1 and CCR7 mimicry in human leukocytes.
Journal
Reference
Authors
Liu Y, de Waal Malefyt R, Briere F, Parham C, Bridon JM, Banchereau J, Moore KW, Xu J
Title
The EBV IL-10 homologue is a selective agonist with impaired binding to the IL-10 receptor.
Journal
J Immunol 158:604-13 (1997)
Reference
Authors
Yoon SI, Jones BC, Logsdon NJ, Walter MR
Title
Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain.
Journal
Reference
Authors
Kotenko SV, Saccani S, Izotova LS, Mirochnitchenko OV, Pestka S
Title
Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10).
Journal
Reference
Authors
Chang WL, Baumgarth N, Yu D, Barry PA
Title
Human cytomegalovirus-encoded interleukin-10 homolog inhibits maturation of dendritic cells and alters their functionality.
Journal
Reference
Authors
Li H, Wang H, Nicholas J
Title
Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling.
Journal
Reference
Authors
Nicot C, Mulloy JC, Ferrari MG, Johnson JM, Fu K, Fukumoto R, Trovato R, Fullen J, Leonard WJ, Franchini G
Title
HTLV-1 p12(I) protein enhances STAT5 activation and decreases the interleukin-2 requirement for proliferation of primary human peripheral blood mononuclear cells.
Journal
Reference
Authors
Xiang Y, Moss B
Title
IL-18 binding and inhibition of interferon gamma induction by human poxvirus-encoded proteins.
Journal
Reference
Authors
Bartlett NW, Dumoutier L, Renauld JC, Kotenko SV, McVey CE, Lee HJ, Smith GL
Title
A new member of the interleukin 10-related cytokine family encoded by a poxvirus.
Journal
Reference
Authors
Strockbine LD, Cohen JI, Farrah T, Lyman SD, Wagener F, DuBose RF, Armitage RJ, Spriggs MK
Title
The Epstein-Barr virus BARF1 gene encodes a novel, soluble colony-stimulating factor-1 receptor.
Journal
Reference
Authors
Snow AL, Martinez OM
Title
Epstein-Barr virus: evasive maneuvers in the development of PTLD.
Journal
Reference
Authors
Shim AH, Chang RA, Chen X, Longnecker R, He X
Title
Multipronged attenuation of macrophage-colony stimulating factor signaling by Epstein-Barr virus BARF1.
Journal
Reference
Authors
Filippova M, Song H, Connolly JL, Dermody TS, Duerksen-Hughes PJ
Title
The human papillomavirus 16 E6 protein binds to tumor necrosis factor (TNF) R1 and protects cells from TNF-induced apoptosis.
Journal
Reference
Authors
Brunetti CR, Paulose-Murphy M, Singh R, Qin J, Barrett JW, Tardivel A, Schneider P, Essani K, McFadden G
Title
A secreted high-affinity inhibitor of human TNF from Tanapox virus.
Journal
Reference
Authors
Sciortino MT, Medici MA, Marino-Merlo F, Zaccaria D, Giuffre-Cuculletto M, Venuti A, Grelli S, Bramanti P, Mastino A
Title
Involvement of gD/HVEM interaction in NF-kB-dependent inhibition of apoptosis by HSV-1 gD.
Journal
Reference
Authors
Smith W, Tomasec P, Aicheler R, Loewendorf A, Nemcovicova I, Wang EC, Stanton RJ, Macauley M, Norris P, Willen L, Ruckova E, Nomoto A, Schneider P, Hahn G, Zajonc DM, Ware CF, Wilkinson GW, Benedict CA
Title
Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses.
Journal
KO pathway