Entry Name Prolactin signaling pathway - Rattus norvegicus (rat)
Description Prolactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and metabolism, brain and behavior, and immunomodulation. PRL mediates its action through PRLR, a transmembrane protein of the hematopoietin cytokine receptor superfamily. At the protein level, the long PRLR isoform (long-R) and several short PRLR isoforms (short-R) have been detected. Acting through the long-R, PRL activates many signaling cascades including Jak2/Stat, the major cascade, Src kinase, phosphatidylinositol-3-kinase (PI3K)/AKT, and mitogen-activated protein kinase (MAPK) pathways. PRL cannot activate Jak2/Stat5 through the short-R, but can activate pathways including MAPK and PI3K pathways.
Class Organismal Systems; Endocrine systemBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Rattus norvegicus (rat) [GN:
rno ]
Gene 24684 Prlr; prolactin receptor isoform a precursor [KO:K05081 ]
85385 Shc1; SHC-transforming protein 1 isoform b [KO:K06279 ]
85243 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
170911 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
366508 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
134484121 LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922 ] [EC:2.7.1.153 ]
25513 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
60664 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
29741 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
81504 Grb2; growth factor receptor-bound protein 2 [KO:K04364 ]
367858 Hrasl1; HRas proto-oncogene, GTPase like 1 [KO:K02833 ]
58960 Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369 ] [EC:2.7.12.2 ]
83681 Cish; cytokine-inducible SH2-containing protein [KO:K04701 ]
252971 Socs1; suppressor of cytokine signaling 1 [KO:K04694 ]
84607 Socs2; suppressor of cytokine signaling 2 [KO:K04695 ]
89829 Socs3; suppressor of cytokine signaling 3 [KO:K04696 ]
305828 Socs4; suppressor of cytokine signaling 4 [KO:K04697 ]
500616 Socs5; suppressor of cytokine signaling 5 [KO:K04698 ]
287659 Socs7; suppressor of cytokine signaling 7 [KO:K04699 ]
307200 Socs6; suppressor of cytokine signaling 6 [KO:K04699 ]
25124 Stat1; signal transducer and activator of transcription 1-alpha/beta isoform beta [KO:K11220 ]
25125 Stat3; signal transducer and activator of transcription 3 [KO:K04692 ]
24918 Stat5a; signal transducer and activator of transcription 5A [KO:K11223 ]
25126 Stat5b; signal transducer and activator of transcription 5B [KO:K11224 ]
117516 Tnfsf11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
498206 Tnfrsf11a; tumor necrosis factor receptor superfamily member 11A precursor [KO:K05147 ]
81736 Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580 ]
366142 Elf5; ETS-related transcription factor Elf-5 [KO:K17101 ]
116700 Cga; glycoprotein hormones alpha chain precursor [KO:K08522 ]
25329 Lhb; lutropin subunit beta isoform 1 precursor [KO:K08521 ]
25477 Lhcgr; lutropin-choriogonadotropic hormone receptor precursor [KO:K04248 ]
25351 Slc2a2; solute carrier family 2, facilitated glucose transporter member 2 [KO:K07593 ]
Compound C00355 3,4-Dihydroxy-L-phenylalanine
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Binart N, Bachelot A, Bouilly J
Title Impact of prolactin receptor isoforms on reproduction.
Journal Reference Authors Bachelot A, Binart N
Title Reproductive role of prolactin.
Journal Reference Authors Hennighausen L, Robinson GW
Title Information networks in the mammary gland.
Journal Reference Authors Bouilly J, Sonigo C, Auffret J, Gibori G, Binart N
Title Prolactin signaling mechanisms in ovary.
Journal Reference Authors Oakes SR, Rogers RL, Naylor MJ, Ormandy CJ
Title Prolactin regulation of mammary gland development.
Journal Reference Authors Frasor J, Gibori G
Title Prolactin regulation of estrogen receptor expression.
Journal Reference Authors Bole-Feysot C, Goffin V, Edery M, Binart N, Kelly PA
Title Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice.
Journal Reference Authors Weinhaus AJ, Stout LE, Bhagroo NV, Brelje TC, Sorenson RL
Title Regulation of glucokinase in pancreatic islets by prolactin: a mechanism for increasing glucose-stimulated insulin secretion during pregnancy.
Journal Reference Authors Grattan DR, Kokay IC
Title Prolactin: a pleiotropic neuroendocrine hormone.
Journal Reference Authors Yu-Lee LY, Luo G, Book ML, Morris SM
Title Lactogenic hormone signal transduction.
Journal Reference Authors Tam SP, Lau P, Djiane J, Hilton DJ, Waters MJ
Title Tissue-specific induction of SOCS gene expression by PRL.
Journal Reference Authors Halperin J, Devi SY, Elizur S, Stocco C, Shehu A, Rebourcet D, Unterman TG, Leslie ND, Le J, Binart N, Gibori G
Title Prolactin signaling through the short form of its receptor represses forkhead transcription factor FOXO3 and its target gene galt causing a severe ovarian defect.
Journal Reference Authors Sakamoto K, Creamer BA, Triplett AA, Wagner KU
Title The Janus kinase 2 is required for expression and nuclear accumulation of cyclin D1 in proliferating mammary epithelial cells.
Journal Reference Authors Oakes SR, Hilton HN, Ormandy CJ
Title The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium.
Journal Related KO pathway
