KEGG   PATHWAY: scl03440Help
Entry
scl03440                    Pathway                                

Name
Homologous recombination - Sorangium cellulosum So ce56
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
scl03440  Homologous recombination
scl03440

Ortholog table
Module
scl_M00260  DNA polymerase III complex, bacteria [PATH:scl03440]
Other DBs
BSID: 62149
GO: 0000724
Organism
Sorangium cellulosum So ce56 [GN:scl]
Gene
sce4480  recJ; single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
sce8612  single-stranded DNA binding protein [KO:K03111]
sce2625  ssb; ssDNA-binding protein [KO:K03111]
sce8165  recF; RecF protein [KO:K03629]
sce1679  recO; DNA repair protein RecO (recombination protein O) [KO:K03584]
sce0257  recR; DNA repair and genetic recombination protein [KO:K06187]
sce5959  recA2; RecA protein [KO:K03553]
sce8671  polA1; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
sce8676  polA2; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
sce0297  ruvA; holliday junction DNA helicase [KO:K03550] [EC:3.6.4.12]
sce7216  ruvB; holliday junction DNA helicase [KO:K03551] [EC:3.6.4.12]
sce5077  ruvC; Holliday Junction Resolvase RuvC [KO:K01159] [EC:3.1.22.4]
sce6272  Crossover junction endodeoxyribonuclease ruvC [KO:K01159] [EC:3.1.22.4]
sce7918  recD; putative exodeoxyribonuclease V [KO:K03581] [EC:3.1.11.5]
sce3750  dnaE2; DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
sce8164  dnaN; DNA polymerase III beta subunit [KO:K02338] [EC:2.7.7.7]
sce0259  dnaX; DNA polymerase III subunit Tau [KO:K02343] [EC:2.7.7.7]
sce5298  holA; putative DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
sce1791  holB; DNA polymerase III delta' subunit [KO:K02341] [EC:2.7.7.7]
sce1712  exonuclease [KO:K02342] [EC:2.7.7.7]
sce7572  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
sce7048  priA; primosomal protein N' [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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