KEGG   PATHWAY: sco00760Help
Entry
sco00760                    Pathway                                

Name
Nicotinate and nicotinamide metabolism - Streptomyces coelicolor
Class
Metabolism; Metabolism of cofactors and vitamins
BRITE hierarchy
Pathway map
sco00760  Nicotinate and nicotinamide metabolism
sco00760

Ortholog table
Module
sco_M00115  NAD biosynthesis, aspartate => NAD [PATH:sco00760]
Other DBs
BSID: 8560
UMBBD: nic
GO: 0006769
Organism
Streptomyces coelicolor [GN:sco]
Gene
SCO3382  nadB; L-aspartate oxidase [KO:K00278] [EC:1.4.3.16]
SCO2162  SC6G10.35; quinolinate synthetase [KO:K03517] [EC:2.5.1.72]
SCO3381  nadC; nicotinate-nucleotide pyrophosphorylase [KO:K00767] [EC:2.4.2.19]
SCO0171  SCJ1.20; nicotinate phosphoribosyltransferase [KO:K00763] [EC:6.3.4.21]
SCO2917  SCE19A.17; nicotinate phosphoribosyltransferase [KO:K00763] [EC:6.3.4.21]
SCO4917  SCK13.09c; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
SCO4152  SCD84.19; 5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
SCO2579  nadD; nicotinic acid mononucleotide adenylyltransferase [KO:K00969] [EC:2.7.7.18]
SCO5186  2SC3B6.10; hypothetical protein [KO:K03426] [EC:3.6.1.22]
SCO0506  nadE; NAD synthetase [KO:K01916] [EC:6.3.1.5]
SCO2238  nadE; NAD(+) synthase (glutamine-hydrolysing) [KO:K01950] [EC:6.3.5.1]
SCO5754  SC7C7.09; hypothetical protein [KO:K03743] [EC:3.5.1.42]
SCO2918  SCE19A.18; nicotinamidase [KO:K08281] [EC:3.5.1.- 3.5.1.19]
SCO1781  ppnK; inorganic polyphosphate/ATP-NAD kinase [KO:K00858] [EC:2.7.1.23]
SCO0410  SCF51.09c; hypothetical protein [KO:K00858] [EC:2.7.1.23]
SCO7623  pntA; NAD(P) transhydrogenase subunit alpha [KO:K00324] [EC:1.6.1.2]
SCO7622  pntB; NAD(P) transhydrogenase subunit beta [KO:K00325] [EC:1.6.1.2]
SCO2823  SCBAC17F8.14c; decarboxylase [KO:K01799] [EC:5.2.1.1]
SCO1204  gabD1; succinic semialdehyde dehydrogenase [KO:K00135] [EC:1.2.1.20 1.2.1.79 1.2.1.16]
SCO7035  gabD; succinate-semialdehyde dehydrogenase [KO:K00135] [EC:1.2.1.20 1.2.1.79 1.2.1.16]
SCO4780  gabD2; succinic semialdehyde dehydrogenase [KO:K00135] [EC:1.2.1.20 1.2.1.79 1.2.1.16]
SCO6244  SCAH10.09c; hypothetical protein [KO:K19190] [EC:1.1.1.328]
Compound
C00003  NAD+
C00006  NADP+
C00022  Pyruvate
C00042  Succinate
C00049  L-Aspartate
C00111  Glycerone phosphate
C00122  Fumarate
C00153  Nicotinamide
C00163  Propanoate
C00232  Succinate semialdehyde
C00253  Nicotinate
C00334  4-Aminobutanoate
C00455  Nicotinamide D-ribonucleotide
C00857  Deamino-NAD+
C00922  2,3-Dimethylmaleate
C01004  N-Methylnicotinate
C01020  6-Hydroxynicotinate
C01056  (S)-6-Hydroxynicotine
C01059  2,5-Dihydroxypyridine
C01185  Nicotinate D-ribonucleotide
C01297  6-Hydroxypseudooxynicotine
C01384  Maleic acid
C01596  Maleamate
C02295  Methylitaconate
C02918  1-Methylnicotinamide
C02930  2-Methyleneglutarate
C03043  (R)-6-Hydroxynicotine
C03056  2,6-Dihydroxypyridine
C03150  Nicotinamide-beta-riboside
C03458  2,3,6-Trihydroxypyridine
C03652  (2R,3S)-2,3-Dimethylmalate
C03722  Quinolinate
C04226  6-Oxo-1,4,5,6-tetrahydronicotinate
C05380  Nicotinurate
C05840  Iminoaspartate
C05841  Nicotinate D-ribonucleoside
C05842  N1-Methyl-2-pyridone-5-carboxamide
C05843  N1-Methyl-4-pyridone-5-carboxamide
C06178  1-Methylpyrrolinium
C15523  2,6-Dihydroxynicotinate
C15986  2,6-Dihydroxypseudooxynicotine
C15987  4-Methylaminobutyrate
C16150  (R,S)-Nicotine
C16151  2,6-Dihydroxy-N-methylmyosmine
C16152  Blue pigment
C16159  2-Formylglutarate
C16390  (S)-2-(Hydroxymethyl)glutarate
C18232  N-Formylmaleamic acid
C19567  4-Oxo-1-(3-pyridyl)-1-butanone
C19569  3-Succinoylpyridine
C19631  6-Hydroxy-3-succinoylpyridine
C20361  Pseudooxynicotine
C20381  3,3'-Bipyridine-2,2',5,5',6,6'-hexol
C21075  5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol
C21154  N-Methylmyosmine
Reference
  Authors
BEHRMAN EJ, STANIER RY.
  Title
The bacterial oxidation of nicotinic acid.
  Journal
J Biol Chem 228:923-45 (1957)
Reference
  Authors
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  Title
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  Journal
Proc Natl Acad Sci U S A 103:12341-6 (2006)
DOI:10.1073/pnas.0601635103
Reference
  Authors
Baitsch D, Sandu C, Brandsch R, Igloi GL.
  Title
Gene cluster on pAO1 of Arthrobacter nicotinovorans involved in degradation of the plant alkaloid nicotine: cloning, purification, and characterization of 2,6-dihydroxypyridine 3-hydroxylase.
  Journal
J Bacteriol 183:5262-7 (2001)
DOI:10.1128/JB.183.18.5262-5267.2001
Reference
  Authors
Sachelaru P, Schiltz E, Igloi GL, Brandsch R.
  Title
An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.
  Journal
J Bacteriol 187:8516-9 (2005)
DOI:10.1128/JB.187.24.8516-8519.2005
Reference
PMID:5835946
  Authors
Gherna RL, Richardson SH, Rittenberg SC
  Title
The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine.
  Journal
J Biol Chem 240:3669-74 (1965)
Reference
  Authors
Galeazzi L, Bocci P, Amici A, Brunetti L, Ruggieri S, Romine M, Reed S, Osterman AL, Rodionov DA, Sorci L, Raffaelli N
  Title
Identification of nicotinamide mononucleotide deamidase of the bacterial pyridine nucleotide cycle reveals a novel broadly conserved amidohydrolase family.
  Journal
J Biol Chem 286:40365-75 (2011)
DOI:10.1074/jbc.M111.275818
KO pathway
ko00760   

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