KEGG   PATHWAY: seg03440Help
Entry
seg03440                    Pathway                                

Name
Homologous recombination - Salmonella enterica subsp. enterica serovar Gallinarum 287/91
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
seg03440  Homologous recombination
seg03440

Ortholog table
Module
seg_M00260  DNA polymerase III complex, bacteria [PATH:seg03440]
Other DBs
BSID: 74652
GO: 0000724
Organism
Salmonella enterica subsp. enterica serovar Gallinarum 287/91 [GN:seg]
Gene
SG2937  recJ; single-stranded DNA-specific exonuclease [KO:K07462] [EC:3.1.-.-]
SG4099  ssb; single-strand DNA-binding protein [KO:K03111]
SG3595  recF; recF protein [KO:K03629]
SG2616  recO; DNA repair protein recO [KO:K03584]
SG0496  recR; recombination protein RecR [KO:K06187]
SG2732  recA; Recombinase A. [KO:K03553]
SG3423  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
SG1157  ruvA; Holliday junction DNA helicase [KO:K03550] [EC:3.6.4.12]
SG1158  ruvB; Holliday junction DNA helicase [KO:K03551] [EC:3.6.4.12]
SG1154  ruvC; crossover junction endodeoxyribonuclease [KO:K01159] [EC:3.1.22.4]
SG3687  recG; ATP-dependent DNA helicase [KO:K03655] [EC:3.6.4.12]
SG2902  recB; exonuclease V subunit [KO:K03582] [EC:3.1.11.5]
SG2904  recC; exonuclease V subunit [KO:K03583] [EC:3.1.11.5]
SG2901  recD; exonuclease V alpha-subunit [KO:K03581] [EC:3.1.11.5]
SG0235  dnaE; DNA polymerase III, alpha chain [KO:K02337] [EC:2.7.7.7]
SG3594  dnaN; DNA polymerase III beta-subunit [KO:K02338] [EC:2.7.7.7]
SG0494  dnaX; DNA polymerase III subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
SG0650  holA; DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
SG1921  holB; DNA polymerase III, delta' subunit [KO:K02341] [EC:2.7.7.7]
SG0262  dnaQ; DNA polymerase III epsilon subunit [KO:K02342] [EC:2.7.7.7]
SG1176  holE; DNA polymerase III, theta subunit [KO:K02345] [EC:2.7.7.7]
SG4301  holC; DNA polymerase III, chi subunit [KO:K02339] [EC:2.7.7.7]
SG4384  holD; DNA polymerase III, psi subunit [KO:K02344] [EC:2.7.7.7]
SG3325  priA; primosomal protein replication factor [KO:K04066] [EC:3.6.4.-]
SG4234  priB; primosomal replication protein N [KO:K02686]
SG0491  priC; primosomal replication protein N [KO:K04067]
SG4374  dnaT; primosomal protein I [KO:K02317]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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