KEGG   PATHWAY: ses02060Help
ses02060                    Pathway                                

Phosphotransferase system (PTS) - Salmonella enterica subsp. arizonae
The phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) is a major mechanism used by bacteria for uptake of carbohydrates, particularly hexoses, hexitols, and disaccharides, where the source of energy is from PEP. The PTS consists of two general components, enzyme I (EI) and histidine phosphocarrier protein (HPr), and of membrane-bound sugar specific permeases (enzymes II). Each enzyme II (EII) complex consists of one or two hydrophobic integral membrane domains (domains C and D) and two hydrophilic domains (domains A and B). EII complexes may exist as distinct proteins or as a single multidomain protein. The PTS catalyzes the uptake of carbohydrates and their conversion into their respective phosphoesters during transport. There are four successive phosphoryl transfers in the PTS. Initial autophosphorylation of EI, using PEP as a substrate, is followed by transfer of the phosphoryl group from EI to HPr. EIIA catalyzes the self-phosphoryl transfer from HPr after which the phosphoryl group is transferred to histidine or cysteine residues of EIIB. The sugar is transported through the membrane-bound EIIC and is phosphorylated by the appropriate sugar-specific EIIB.
Environmental Information Processing; Membrane transport
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Pathway map
ses02060  Phosphotransferase system (PTS)

Ortholog table
ses_M00265  PTS system, glucose-specific II component [PATH:ses02060]
ses_M00266  PTS system, maltose/glucose-specific II component [PATH:ses02060]
ses_M00267  PTS system, N-acetylglucosamine-specific II component [PATH:ses02060]
ses_M00270  PTS system, trehalose-specific II component [PATH:ses02060]
ses_M00273  PTS system, fructose-specific II component [PATH:ses02060]
ses_M00274  PTS system, mannitol-specific II component [PATH:ses02060]
ses_M00275  PTS system, cellobiose-specific II component [PATH:ses02060]
ses_M00276  PTS system, mannose-specific II component [PATH:ses02060]
ses_M00277  PTS system, N-acetylgalactosamine-specific II component [PATH:ses02060]
ses_M00280  PTS system, glucitol/sorbitol-specific II component [PATH:ses02060]
ses_M00283  PTS system, ascorbate-specific II component [PATH:ses02060]
ses_M00303  PTS system, N-acetylmuramic acid-specific II component [PATH:ses02060]
ses_M00764  PTS system, fructoselysine/glucoselysine-specific II component [PATH:ses02060]
Other DBs
BSID: 61521
GO: 0009401
TC: 4.A
Salmonella enterica subsp. arizonae [GN:ses]
SARI_00455  hypothetical protein [KO:K08483] [EC:]
SARI_00486  hypothetical protein [KO:K08483 K11189 K11201] [EC: 2.7.1.-]
SARI_00456  hypothetical protein [KO:K02784]
SARI_00454  hypothetical protein [KO:K02777] [EC:2.7.1.-]
SARI_01788  hypothetical protein [KO:K02778 K02779] [EC:]
SARI_02256  hypothetical protein [KO:K02802 K02803 K02804] [EC:]
SARI_01514  hypothetical protein [KO:K02790 K02791] [EC:]
SARI_03958  hypothetical protein [KO:K02790 K02791] [EC:]
SARI_03198  hypothetical protein [KO:K02818 K02819] [EC:]
SARI_00438  hypothetical protein [KO:K11191 K11192] [EC:]
SARI_03955  hypothetical protein [KO:K02798 K02799 K02800] [EC:]
SARI_04563  hypothetical protein [KO:K02798] [EC:]
SARI_04564  hypothetical protein [KO:K02799 K02800] [EC:]
SARI_01664  hypothetical protein [KO:K02759] [EC:]
SARI_01666  hypothetical protein [KO:K02760] [EC:]
SARI_01665  hypothetical protein [KO:K02761]
SARI_02173  hypothetical protein [KO:K02761]
SARI_01110  hypothetical protein [KO:K02793 K02794] [EC:]
SARI_02360  hypothetical protein [KO:K02793] [EC:]
SARI_02361  hypothetical protein [KO:K02794] [EC:]
SARI_01109  hypothetical protein [KO:K02795]
SARI_02362  hypothetical protein [KO:K02795]
SARI_01108  hypothetical protein [KO:K02796]
SARI_02363  hypothetical protein [KO:K02796]
SARI_03044  hypothetical protein [KO:K19506] [EC:2.7.1.-]
SARI_03043  hypothetical protein [KO:K19507] [EC:2.7.1.-]
SARI_03042  hypothetical protein [KO:K19508]
SARI_03041  hypothetical protein [KO:K19509]
SARI_01161  hypothetical protein [KO:K02744] [EC:2.7.1.-]
SARI_01158  hypothetical protein [KO:K02745] [EC:2.7.1.-]
SARI_01159  hypothetical protein [KO:K02746]
SARI_01160  hypothetical protein [KO:K02747]
SARI_00138  hypothetical protein [KO:K02781] [EC:]
SARI_00139  hypothetical protein [KO:K02782 K02783] [EC:]
SARI_00140  hypothetical protein [KO:K02783]
SARI_00555  hypothetical protein [KO:K02821] [EC:]
SARI_03249  hypothetical protein [KO:K02821] [EC:]
SARI_00557  hypothetical protein [KO:K02822] [EC:]
SARI_02045  hypothetical protein [KO:K02822] [EC:]
SARI_03250  hypothetical protein [KO:K02822] [EC:]
SARI_03251  hypothetical protein [KO:K03475]
SARI_02046  hypothetical protein [KO:K03475]
SARI_00558  hypothetical protein [KO:K03475]
SARI_00679  hypothetical protein [KO:K02768 K11183] [EC:]
SARI_00681  hypothetical protein [KO:K02769 K02770] [EC:]
SARI_04656  hypothetical protein [KO:K08484] [EC:]
SARI_04301  hypothetical protein [KO:K08485]
SARI_04303  hypothetical protein [KO:K02806] [EC:2.7.1.-]
C00022  Pyruvate
C00031  D-Glucose
C00072  Ascorbate
C00074  Phosphoenolpyruvate
C00089  Sucrose
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00124  D-Galactose
C00140  N-Acetyl-D-glucosamine
C00159  D-Mannose
C00185  Cellobiose
C00208  Maltose
C00243  Lactose
C00275  D-Mannose 6-phosphate
C00329  D-Glucosamine
C00352  D-Glucosamine 6-phosphate
C00357  N-Acetyl-D-glucosamine 6-phosphate
C00392  Mannitol
C00644  D-Mannitol 1-phosphate
C00689  alpha,alpha'-Trehalose 6-phosphate
C00697  Nitrogen
C00794  D-Sorbitol
C01083  alpha,alpha-Trehalose
C01094  D-Fructose 1-phosphate
C01096  Sorbitol 6-phosphate
C01113  D-Galactose 6-phosphate
C01132  N-Acetyl-D-galactosamine
C01451  Salicin
C01452  Sorbose
C01674  Chitobiose
C01697  Galactitol
C01798  D-Glucoside
C02262  D-Galactosamine
C02713  N-Acetylmuramate
C02888  Sorbose 1-phosphate
C02995  Maltose 6'-phosphate
C03752  2-Amino-2-deoxy-D-gluconate
C04534  6-Phospho-beta-D-glucosyl-(1,4)-D-glucose
C05396  Lactose 6'-phosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C06311  Galactitol 1-phosphate
C06376  N-Acetyl-D-galactosamine 6-phosphate
C06377  D-Galactosamine 6-phosphate
C11544  2-O-(alpha-D-Mannosyl)-D-glycerate
C16186  L-Ascorbate 6-phosphate
C16488  Fructoselysine
C16489  Fructoselysine 6-phosphate
C16688  Sucrose 6-phosphate
C16698  N-Acetylmuramic acid 6-phosphate
C16699  2-O-(6-Phospho-alpha-mannosyl)-D-glycerate
C20589  D-Glucosaminate-6-phosphate
C20978  Glucoselysine
C20979  Glucoselysine-6-phosphate
C21152  N,N'-Diacetylchitobiose 6'-phosphate
Darbon E, Galinier A, Le Coq D, Deutscher J.
Phosphotransfer functions mutated Bacillus subtilis HPr-like protein Crh carrying a histidine in the active site.
J Mol Microbiol Biotechnol 3:439-44 (2001)
Dahl U, Jaeger T, Nguyen BT, Sattler JM, Mayer C.
Identification of a phosphotransferase system of Escherichia coli required for growth on N-acetylmuramic acid.
J Bacteriol 186:2385-92 (2004)
Martin-Verstraete I, Debarbouille M, Klier A, Rapoport G
Levanase operon of Bacillus subtilis includes a fructose-specific phosphotransferase system regulating the expression of the operon.
J Mol Biol 214:657-71 (1990)
Kristich CJ, Glekas GD, Ordal GW.
The conserved cytoplasmic module of the transmembrane chemoreceptor McpC mediates carbohydrate chemotaxis in Bacillus subtilis.
Mol Microbiol 47:1353-66 (2003)
Sampaio MM, Chevance F, Dippel R, Eppler T, Schlegel A, Boos W, Lu YJ, Rock CO.
Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor.
J Biol Chem 279:5537-48 (2004)
Keseler IM, Collado-Vides J, Gama-Castro S, Ingraham J, Paley S, Paulsen IT, Peralta-Gil M, Karp PD.
EcoCyc: a comprehensive database resource for Escherichia coli.
Nucleic Acids Res 33:D334-7 (2005)
Mukherjee A, Mammel MK, LeClerc JE, Cebula TA.
Altered utilization of N-acetyl-D-galactosamine by Escherichia coli O157:H7 from the 2006 spinach outbreak.
J Bacteriol 190:1710-7 (2008)
Brinkkotter A, Kloss H, Alpert C, Lengeler JW.
Pathways for the utilization of N-acetyl-galactosamine and galactosamine in Escherichia coli.
Mol Microbiol 37:125-35 (2000)
Tchieu JH, Norris V, Edwards JS, Saier MH Jr.
The complete phosphotranferase system in Escherichia coli.
J Mol Microbiol Biotechnol 3:329-46 (2001)
Kotrba P, Inui M, Yukawa H.
Bacterial phosphotransferase system (PTS) in carbohydrate uptake and control of carbon metabolism.
J Biosci Bioeng 92:502-17 (2001)
KO pathway

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