KEGG   PATHWAY: sfc03440Help
Entry
sfc03440                    Pathway                                

Name
Homologous recombination - Spirochaeta africana
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
sfc03440  Homologous recombination
sfc03440

Ortholog table
Other DBs
BSID: 588240
GO: 0000724
Organism
Spirochaeta africana [GN:sfc]
Gene
Spiaf_1443  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
Spiaf_1998  single stranded DNA-binding protein [KO:K03111]
Spiaf_1587  single stranded DNA-binding protein [KO:K03111]
Spiaf_2552  single stranded DNA-binding protein [KO:K03111]
Spiaf_0003  recF protein [KO:K03629]
Spiaf_1440  DNA repair protein RecO [KO:K03584]
Spiaf_2860  recombination protein RecR [KO:K06187]
Spiaf_1521  protein RecA [KO:K03553]
Spiaf_2716  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
Spiaf_1552  Holliday junction DNA helicase, RuvA subunit [KO:K03550] [EC:3.6.4.12]
Spiaf_1551  Holliday junction DNA helicase, RuvB subunit [KO:K03551] [EC:3.6.4.12]
Spiaf_1553  crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.22.4]
Spiaf_2227  RecG-like helicase [KO:K03655] [EC:3.6.4.12]
Spiaf_2225  DNA-directed DNA polymerase III PolC [KO:K02337] [EC:2.7.7.7]
Spiaf_0002  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
Spiaf_0590  hypothetical protein [KO:K02343] [EC:2.7.7.7]
Spiaf_2862  DNA polymerase III, subunit gamma/tau [KO:K02343] [EC:2.7.7.7]
Spiaf_2663  DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
Spiaf_0831  exonuclease, DNA polymerase III, epsilon subunit family [KO:K02342] [EC:2.7.7.7]
Spiaf_1079  primosomal protein N'' [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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