KEGG   PATHWAY: shb02060Help
Entry
shb02060                    Pathway                                

Name
Phosphotransferase system (PTS) - Salmonella enterica subsp. enterica serovar Heidelberg B182
Description
The phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) is a major mechanism used by bacteria for uptake of carbohydrates, particularly hexoses, hexitols, and disaccharides, where the source of energy is from PEP. The PTS consists of two general components, enzyme I (EI) and histidine phosphocarrier protein (HPr), and of membrane-bound sugar specific permeases (enzymes II). Each enzyme II (EII) complex consists of one or two hydrophobic integral membrane domains (domains C and D) and two hydrophilic domains (domains A and B). EII complexes may exist as distinct proteins or as a single multidomain protein. The PTS catalyzes the uptake of carbohydrates and their conversion into their respective phosphoesters during transport. There are four successive phosphoryl transfers in the PTS. Initial autophosphorylation of EI, using PEP as a substrate, is followed by transfer of the phosphoryl group from EI to HPr. EIIA catalyzes the self-phosphoryl transfer from HPr after which the phosphoryl group is transferred to histidine or cysteine residues of EIIB. The sugar is transported through the membrane-bound EIIC and is phosphorylated by the appropriate sugar-specific EIIB.
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
shb02060  Phosphotransferase system (PTS)
shb02060

Ortholog table
Module
shb_M00265  PTS system, glucose-specific II component [PATH:shb02060]
shb_M00267  PTS system, N-acetylglucosamine-specific II component [PATH:shb02060]
shb_M00270  PTS system, trehalose-specific II component [PATH:shb02060]
shb_M00273  PTS system, fructose-specific II component [PATH:shb02060]
shb_M00274  PTS system, mannitol-specific II component [PATH:shb02060]
shb_M00275  PTS system, cellobiose-specific II component [PATH:shb02060]
shb_M00276  PTS system, mannose-specific II component [PATH:shb02060]
shb_M00279  PTS system, galactitol-specific II component [PATH:shb02060]
shb_M00280  PTS system, glucitol/sorbitol-specific II component [PATH:shb02060]
shb_M00283  PTS system, ascorbate-specific II component [PATH:shb02060]
shb_M00610  PTS system, D-glucosaminate-specific II component [PATH:shb02060]
shb_M00764  PTS system, fructoselysine/glucoselysine-specific II component [PATH:shb02060]
Other DBs
BSID: 615050
GO: 0009401
TC: 4.A
Organism
Salmonella enterica subsp. enterica serovar Heidelberg B182 [GN:shb]
Gene
SU5_03035  Phosphoenolpyruvate-protein phosphotransferase of PTS system [KO:K08483] [EC:2.7.3.9]
SU5_03034  Phosphotransferase system, phosphocarrier protein HPr [KO:K02784]
SU5_03246  PTS system, glucose-specific IIB component [KO:K20117 K20118] [EC:2.7.1.199]
SU5_03036  PTS system, glucose-specific IIA component [KO:K02777] [EC:2.7.1.-]
SU5_01829  PTS system, glucose-specific IIB component [KO:K02778 K02779] [EC:2.7.1.199]
SU5_01369  PTS system, N-acetylglucosamine-component [KO:K02802 K02803 K02804] [EC:2.7.1.193 2.7.1.193]
SU5_03166  PTS, N-acetylmuramic acid component [KO:K02809 K02810] [EC:2.7.1.211]
SU5_0503  PTS system, trehalose-specific IIB component [KO:K02818 K02819] [EC:2.7.1.201]
SU5_04162  PTS system, mannitol-specific IIC component [KO:K02798 K02799 K02800] [EC:2.7.1.197 2.7.1.197]
SU5_01933  PTS system, chitobiose-specific IIA component [KO:K02759] [EC:2.7.1.205 2.7.1.196]
SU5_01931  PTS system, chitobiose-specific IIB component [KO:K02760] [EC:2.7.1.205 2.7.1.196]
SU5_01932  PTS system, chitobiose-specific IIC component [KO:K02761]
SU5_01267  PTS system, mannose-specific IIA component [KO:K02793] [EC:2.7.1.191]
SU5_02432  PTS system, mannose-specific IIA component [KO:K02793 K02794] [EC:2.7.1.191 2.7.1.191]
SU5_01266  PTS system, mannose-specific IIB component [KO:K02794] [EC:2.7.1.191]
SU5_01265  PTS system, mannose-specific IIC component [KO:K02795]
SU5_02433  PTS system, mannose-specific IIC component [KO:K02795]
SU5_02434  PTS system, mannose-specific IID component [KO:K02796]
SU5_0577  PTS system, mannose-specific IIA component [KO:K19506] [EC:2.7.1.-]
SU5_0578  PTS system, mannose-specific IIB component [KO:K19507] [EC:2.7.1.-]
SU5_0579  PTS system, mannose-specific IIC component [KO:K19508]
SU5_01264  PTS system, mannose-specific IID component [KO:K19509]
SU5_0580  PTS system, mannose-specific IID component [KO:K19509]
SU5_04248  PTS system, mannose-specific IIA component [KO:K17464] [EC:2.7.1.203]
SU5_04247  PTS system, mannose-specific IIA component [KO:K17465] [EC:2.7.1.203]
SU5_04246  PTS system, mannose-specific IIC component [KO:K17466]
SU5_04245  PTS system, mannose-specific IID component [KO:K17467]
SU5_03239  PTS system, glucitol/sorbitol-specific IIA component [KO:K02781] [EC:2.7.1.198]
SU5_03315  PTS system, glucitol/sorbitol-specific IIA component [KO:K02781] [EC:2.7.1.198]
SU5_03240  PTS system, glucitol/sorbitol-specific IIB component and second of two IIC components [KO:K02782 K02783] [EC:2.7.1.198]
SU5_03314  PTS system, glucitol/sorbitol-specific IIB component and second of two IIC components [KO:K02782 K02783] [EC:2.7.1.198]
SU5_03313  PTS system, glucitol/sorbitol-specific IIC component [KO:K02783]
SU5_03238  PTS system, glucitol/sorbitol-specific IIC component [KO:K02783]
SU5_04261  Carbohydrate PTS system, IIA component [KO:K02773] [EC:2.7.1.200]
SU5_03529  PTS system, galactitol-specific IIA component [KO:K02773] [EC:2.7.1.200]
SU5_03534  PTS system, galactitol-specific IIA component [KO:K02773] [EC:2.7.1.200]
SU5_03746  PTS system, galactitol-specific IIA component [KO:K02773] [EC:2.7.1.200]
SU5_02228  PTS system, IIA component [KO:K02773] [EC:2.7.1.200]
SU5_04260  Carbohydrate PTS system, IIB component [KO:K02774] [EC:2.7.1.200]
SU5_03528  PTS system, galactitol-specific IIB component [KO:K02774] [EC:2.7.1.200]
SU5_03533  Phosphotransferase system, galactitol-specific IIB component [KO:K02774] [EC:2.7.1.200]
SU5_03747  PTS system, galactitol-specific IIB component [KO:K02774] [EC:2.7.1.200]
SU5_02225  Putative phosphotransferase enzyme [KO:K02774] [EC:2.7.1.200]
SU5_02226  PTS system, galactitol-specific IIC component [KO:K02775]
SU5_03748  PTS system, galactitol-specific IIC component [KO:K02775]
SU5_04259  Carbohydrate PTS system, IIC component [KO:K02775]
SU5_03527  PTS system, galactitol-specific IIC component [KO:K02775]
SU5_03532  PTS system, galactitol-specific IIC component [KO:K02775]
SU5_02938  PTS system, IIA component [KO:K02821] [EC:2.7.1.194]
SU5_0455  Ascorbate-specific PTS system, EIIA component [KO:K02821] [EC:2.7.1.194]
SU5_02937  Putative sugar phosphotransferase component II B [KO:K02822] [EC:2.7.1.194]
SU5_01553  Putative phosphotransferase enzyme II, B component [KO:K02822] [EC:2.7.1.194]
SU5_0454  Ascorbate-specific PTS system, EIIB component [KO:K02822] [EC:2.7.1.194]
SU5_02936  PTS system ascorbate-specific transporter subunit IIC [KO:K03475]
SU5_01552  Transport protein SgaT, putative [KO:K03475]
SU5_0453  ulaA PTS system sugar-specific permease [KO:K03475]
SU5_02798  Fructose-specific phosphocarrier protein HPr [KO:K02768 K11183] [EC:2.7.1.202]
SU5_02796  PTS system, fructose-specific IIB component [KO:K02769 K02770] [EC:2.7.1.202]
SU5_04333  PTS system, fructose-specific IIB component [KO:K02769 K02770] [EC:2.7.1.202]
SU5_03491  Phosphocarrier protein kinase/phosphorylase, nitrogen regulation associated [KO:K08484] [EC:2.7.3.9]
SU5_03809  Phosphocarrier protein, nitrogen regulation associated [KO:K08485]
SU5_03807  PTS IIA-like nitrogen-regulatory protein PtsN [KO:K02806] [EC:2.7.1.-]
Compound
C00022  Pyruvate
C00031  D-Glucose
C00072  Ascorbate
C00074  Phosphoenolpyruvate
C00089  Sucrose
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00124  D-Galactose
C00140  N-Acetyl-D-glucosamine
C00159  D-Mannose
C00185  Cellobiose
C00208  Maltose
C00243  Lactose
C00275  D-Mannose 6-phosphate
C00329  D-Glucosamine
C00352  D-Glucosamine 6-phosphate
C00357  N-Acetyl-D-glucosamine 6-phosphate
C00392  Mannitol
C00644  D-Mannitol 1-phosphate
C00689  alpha,alpha'-Trehalose 6-phosphate
C00697  Nitrogen
C00794  D-Sorbitol
C01083  alpha,alpha-Trehalose
C01094  D-Fructose 1-phosphate
C01096  Sorbitol 6-phosphate
C01113  D-Galactose 6-phosphate
C01132  N-Acetyl-D-galactosamine
C01451  Salicin
C01452  Sorbose
C01674  Chitobiose
C01697  Galactitol
C01798  D-Glucoside
C02262  D-Galactosamine
C02713  N-Acetylmuramate
C02888  Sorbose 1-phosphate
C02995  Maltose 6'-phosphate
C03752  2-Amino-2-deoxy-D-gluconate
C04534  6-Phospho-beta-D-glucosyl-(1,4)-D-glucose
C05396  Lactose 6'-phosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C06311  Galactitol 1-phosphate
C06376  N-Acetyl-D-galactosamine 6-phosphate
C06377  D-Galactosamine 6-phosphate
C11544  2-O-(alpha-D-Mannosyl)-D-glycerate
C16186  L-Ascorbate 6-phosphate
C16488  Fructoselysine
C16489  Fructoselysine 6-phosphate
C16688  Sucrose 6-phosphate
C16698  N-Acetylmuramic acid 6-phosphate
C16699  2-O-(6-Phospho-alpha-mannosyl)-D-glycerate
C20589  D-Glucosaminate-6-phosphate
C20978  Glucoselysine
C20979  Glucoselysine-6-phosphate
C21152  N,N'-Diacetylchitobiose 6'-phosphate
Reference
  Authors
Darbon E, Galinier A, Le Coq D, Deutscher J.
  Title
Phosphotransfer functions mutated Bacillus subtilis HPr-like protein Crh carrying a histidine in the active site.
  Journal
J Mol Microbiol Biotechnol 3:439-44 (2001)
Reference
  Authors
Dahl U, Jaeger T, Nguyen BT, Sattler JM, Mayer C.
  Title
Identification of a phosphotransferase system of Escherichia coli required for growth on N-acetylmuramic acid.
  Journal
J Bacteriol 186:2385-92 (2004)
DOI:10.1128/JB.186.8.2385-2392.2004
Reference
PMID:2117666
  Authors
Martin-Verstraete I, Debarbouille M, Klier A, Rapoport G
  Title
Levanase operon of Bacillus subtilis includes a fructose-specific phosphotransferase system regulating the expression of the operon.
  Journal
J Mol Biol 214:657-71 (1990)
DOI:10.1016/0022-2836(90)90284-S
Reference
  Authors
Kristich CJ, Glekas GD, Ordal GW.
  Title
The conserved cytoplasmic module of the transmembrane chemoreceptor McpC mediates carbohydrate chemotaxis in Bacillus subtilis.
  Journal
Mol Microbiol 47:1353-66 (2003)
DOI:10.1046/j.1365-2958.2003.03375.x
Reference
  Authors
Sampaio MM, Chevance F, Dippel R, Eppler T, Schlegel A, Boos W, Lu YJ, Rock CO.
  Title
Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor.
  Journal
J Biol Chem 279:5537-48 (2004)
DOI:10.1074/jbc.M310980200
Reference
  Authors
Keseler IM, Collado-Vides J, Gama-Castro S, Ingraham J, Paley S, Paulsen IT, Peralta-Gil M, Karp PD.
  Title
EcoCyc: a comprehensive database resource for Escherichia coli.
  Journal
Nucleic Acids Res 33:D334-7 (2005)
DOI:10.1093/nar/gki108
Reference
  Authors
Mukherjee A, Mammel MK, LeClerc JE, Cebula TA.
  Title
Altered utilization of N-acetyl-D-galactosamine by Escherichia coli O157:H7 from the 2006 spinach outbreak.
  Journal
J Bacteriol 190:1710-7 (2008)
DOI:10.1128/JB.01737-07
Reference
  Authors
Brinkkotter A, Kloss H, Alpert C, Lengeler JW.
  Title
Pathways for the utilization of N-acetyl-galactosamine and galactosamine in Escherichia coli.
  Journal
Mol Microbiol 37:125-35 (2000)
DOI:10.1046/j.1365-2958.2000.01969.x
Reference
  Authors
Tchieu JH, Norris V, Edwards JS, Saier MH Jr.
  Title
The complete phosphotranferase system in Escherichia coli.
  Journal
J Mol Microbiol Biotechnol 3:329-46 (2001)
Reference
  Authors
Kotrba P, Inui M, Yukawa H.
  Title
Bacterial phosphotransferase system (PTS) in carbohydrate uptake and control of carbon metabolism.
  Journal
J Biosci Bioeng 92:502-17 (2001)
DOI:10.1016/S1389-1723(01)80308-X
KO pathway
ko02060   

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