KEGG   PATHWAY: smc03440Help
Entry
smc03440                    Pathway                                

Name
Homologous recombination - Streptococcus mutans NN2025 (serotype c)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
smc03440  Homologous recombination
smc03440

Ortholog table
Module
smc_M00260  DNA polymerase III complex, bacteria [PATH:smc03440]
Other DBs
BSID: 144618
GO: 0000724
Organism
Streptococcus mutans NN2025 (serotype c) [GN:smc]
Gene
SmuNN2025_0637  recJ; putative single-strand DNA-specific exonuclease [KO:K07462] [EC:3.1.-.-]
SmuNN2025_0190  ssb2; putative single-stranded DNA-binding protein [KO:K03111]
SmuNN2025_0280  ssb; putative single-stranded DNA-binding protein [KO:K03111]
SmuNN2025_1887  recF; putative RecF protein [KO:K03629]
SmuNN2025_0021  recO; putative DNA repair protein [KO:K03584]
SmuNN2025_1380  recR; putative recombination protein [KO:K06187]
SmuNN2025_1824  recA; recombination protein [KO:K03553]
SmuNN2025_1670  polI; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
SmuNN2025_1827  putative Holliday junction DNA helicase [KO:K03550] [EC:3.6.4.12]
SmuNN2025_0052  rubB; Holliday junction DNA helicase [KO:K03551] [EC:3.6.4.12]
SmuNN2025_0304  recG; putative ATP-dependent DNA helicase [KO:K03655] [EC:3.6.4.12]
SmuNN2025_0267  putative exodeoxyribonuclease V [KO:K03581] [EC:3.1.11.5]
SmuNN2025_0854  dnaE; DNA polymerase III alpha chain [KO:K02337] [EC:2.7.7.7]
SmuNN2025_0112  DNA polymerase III alpha subunit [KO:K03763] [EC:2.7.7.7]
SmuNN2025_0002  dnaN; putative DNA polymerase III beta subunit [KO:K02338] [EC:2.7.7.7]
SmuNN2025_0528  dnaX; DNA polymerase III gamma/tau subunit [KO:K02343] [EC:2.7.7.7]
SmuNN2025_1359  hypothetical protein [KO:K02340] [EC:2.7.7.7]
SmuNN2025_0455  holB; putative DNA polymerase III delta subunit [KO:K02341] [EC:2.7.7.7]
SmuNN2025_1491  priA; primosome assembly protein [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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