KEGG   PATHWAY: sme03440
Entry
sme03440                    Pathway                                
Name
Homologous recombination - Sinorhizobium meliloti 1021
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
sme03440  Homologous recombination
sme03440

Other DBs
GO: 0000724
Organism
Sinorhizobium meliloti 1021 [GN:sme]
Gene
SMc00292  recJ; Probable single-stranded-DNA-specific exonuclease [KO:K07462] [EC:3.1.-.-]
SMc01233  ssb; Probable single-strand binding protein [KO:K03111]
SMc02863  recF; DNA repair protein [KO:K03629]
SMc02635  recO; Recombinational DNA repair protein (RecF pathway) [KO:K03584]
SMc02908  recR; Probable recombination protein [KO:K06187]
SMc00760  recA; DNA strand exchange and recombination protein [KO:K03553]
SMc02850  polA; Probable DNA polymerase I [KO:K02335] [EC:2.7.7.7]
SMc03966  ruvA; Probable holliday junction DNA helicase [KO:K03550]
SMc03965  ruvB; Probable holliday junction DNA helicase [KO:K03551] [EC:5.6.2.4]
SMc03967  ruvC; Probable holliday junction endodeoxyribonuclease [KO:K01159] [EC:3.1.21.10]
SMc00228  recG; Probable ATP-dependent DNA helicase [KO:K03655] [EC:5.6.2.4]
SMc01375  dnaE1; Probable DNA polymerase III, alpha chain [KO:K02337] [EC:2.7.7.7]
SMc00415  dnaN; Probable DNA polymerase III, beta chain [KO:K02338] [EC:2.7.7.7]
SMc02905  dnaX; Putative DNA polymerase III subunit TAU protein [KO:K02343] [EC:2.7.7.7]
SMc02802  Putative DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
SMc01190  Putative DNA polymerase III, delta' subunit [KO:K02341] [EC:2.7.7.7]
SMc02789  dnaQ; Probable DNA polymerase III, epsilon chain [KO:K02342] [EC:2.7.7.7]
SMa0255  conserved hypothetical protein [KO:K02342] [EC:2.7.7.7]
SMc00586  Putative DNA polymerase III chi subunit [KO:K02339] [EC:2.7.7.7]
SMc02496  priA; Probable primosomal protein N' (replication factor Y) [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG GENES (20)   
All databases (21)   

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