KEGG   PATHWAY: smx03440
Entry
smx03440                    Pathway                                
Name
Homologous recombination - Sinorhizobium meliloti SM11
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
smx03440  Homologous recombination
smx03440

Other DBs
GO: 0000724
Organism
Sinorhizobium meliloti SM11 [GN:smx]
Gene
SM11_chr1678  recJ; single-stranded-DNA-specific exonuclease [KO:K07462] [EC:3.1.-.-]
SM11_chr2007  ssb; single-strand DNA-binding protein [KO:K03111]
SM11_chr3660  recF; DNA replication and repair protein recF [KO:K03629]
SM11_chr0753  recO; probabable RecO [KO:K03584]
SM11_chr3707  recR; Recombination protein recR [KO:K06187]
SM11_chr1599  recA; recombinase A [KO:K03553]
SM11_chr3647  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
SM11_chr2914  ruvA; Holliday junction DNA helicase motor protein [KO:K03550]
SM11_chr2913  ruvB; Holliday junction DNA helicase B [KO:K03551] [EC:5.6.2.4]
SM11_chr2915  ruvC; crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.21.10]
SM11_chr1755  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
SM11_chr2285  dnaE1; putative DNA polymerase III alpha chain protein [KO:K02337] [EC:2.7.7.7]
SM11_chr3812  dnaN; DNA polymerase III beta subunit [KO:K02338] [EC:2.7.7.7]
SM11_chr3704  dnaX; DNA polymerase III subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
SM11_chr3457  putative DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
SM11_chr1957  holB; DNA polymerase III, delta prime subunit [KO:K02341] [EC:2.7.7.7]
SM11_pC1603  conserved hypothetical protein [KO:K02342] [EC:2.7.7.7]
SM11_chr3470  dnaQ; DNA polymerase III epsilon subunit [KO:K02342] [EC:2.7.7.7]
SM11_chr2508  putative DNA polymerase III chi subunit [KO:K02339] [EC:2.7.7.7]
SM11_chr3218  priA; probabable primosomal protein N' (replication factor Y) [KO:K04066] [EC:5.6.2.4]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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