KEGG   PATHWAY: spm03440
Entry
spm03440                    Pathway                                
Name
Homologous recombination - Streptococcus pyogenes MGAS8232 (serotype M18)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
spm03440  Homologous recombination
spm03440

Other DBs
GO: 0000724
Organism
Streptococcus pyogenes MGAS8232 (serotype M18) [GN:spm]
Gene
spyM18_0983  recJ; putative single-strand DNA-specific exonuclease [KO:K07462] [EC:3.1.-.-]
spyM18_1795  ssb; putative single strand binding protein [KO:K03111]
spyM18_0359  ssb; putative single strand binding protein [KO:K03111]
spyM18_1896  ssb; putative single strand binding protein [KO:K03111]
spyM18_0120  ssb; putative single-strand binding protein [KO:K03111]
spyM18_2242  recF; recF protein [KO:K03629]
spyM18_0022  conserved hypothetical protein [KO:K03584]
spyM18_1432  recR; putative recombination protein [KO:K06187]
spyM18_2174  recA; recombination protein [KO:K03553]
spyM18_0184  DNA-directed DNA polymerase I [KO:K02335] [EC:2.7.7.7]
spyM18_2177  ruvA; putative Holliday junction DNA helicase [KO:K03550]
spyM18_0039  ruvB; putative Holliday junction DNA helicase, subunit B [KO:K03551] [EC:5.6.2.4]
spyM18_1857  recG; putative ATP-dependent DNA helicase [KO:K03655] [EC:5.6.2.4]
spyM18_1908  putative exodeoxyribonuclease V (alpha subunit) [KO:K03581] [EC:3.1.11.5]
spyM18_1232  dnaE; DNA polymerase III alpha subunit [KO:K02337] [EC:2.7.7.7]
spyM18_2028  dnaE; DNA polymerase III alpha chain [KO:K03763] [EC:2.7.7.7]
spyM18_0002  dnaN; beta subunit of DNA polymerase III [KO:K02338] [EC:2.7.7.7]
spyM18_1376  dnaX; DNA polymerase III gamma/tau subunits [KO:K02343] [EC:2.7.7.7]
spyM18_1415  DNA polymerase III delta subunit [KO:K02340] [EC:2.7.7.7]
spyM18_0450  putative DNA polymerase III delta subunit [KO:K02341] [EC:2.7.7.7]
spyM18_1928  putative DNA polymerase III epsilon subunit [KO:K02342] [EC:2.7.7.7]
spyM18_1639  priA; putative primosomal replication factor Y [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG GENES (22)   
All databases (23)   

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