KEGG   PATHWAY: ssl04145Help
Entry
ssl04145                    Pathway                                

Name
Phagosome - Sclerotinia sclerotiorum
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
ssl04145  Phagosome
ssl04145

Ortholog table
Module
ssl_M00401  Sec61 complex [PATH:ssl04145]
Other DBs
BSID: 153976
GO: 0045335
Organism
Sclerotinia sclerotiorum [GN:ssl]
Gene
SS1G_08733  actin [KO:K05692]
SS1G_08767  hypothetical protein [KO:K08517]
SS1G_13149  hypothetical protein [KO:K07889]
SS1G_07405  conserved hypothetical protein [KO:K07889]
SS1G_11324  hypothetical protein [KO:K00914] [EC:2.7.1.137]
SS1G_02264  hypothetical protein [KO:K12182]
SS1G_03787  vacuolar ATP synthase catalytic subunit A [KO:K02145] [EC:3.6.3.14]
SS1G_10682  hypothetical protein [KO:K02147]
SS1G_14389  hypothetical protein [KO:K02148]
SS1G_08580  vacuolar ATP synthase subunit D [KO:K02149]
SS1G_05589  vacuolar ATP synthase subunit E [KO:K02150]
SS1G_07612  hypothetical protein [KO:K02151]
SS1G_00887  predicted protein [KO:K02152]
SS1G_13993  predicted protein [KO:K02153]
SS1G_12196  hypothetical protein [KO:K02154]
SS1G_12213  vacuolar ATP synthase subunit d1 [KO:K02146]
SS1G_06758  hypothetical protein [KO:K02144]
SS1G_10240  vacuolar ATP synthase 16 kDa proteolipid subunit [KO:K02155]
SS1G_03179  hypothetical protein [KO:K02155]
SS1G_08505  hypothetical protein [KO:K03661]
SS1G_03128  hypothetical protein [KO:K07897]
SS1G_08486  hypothetical protein [KO:K10413]
SS1G_01856  hypothetical protein [KO:K10415]
SS1G_03312  hypothetical protein [KO:K10416]
SS1G_01548  tubulin alpha chain [KO:K07374]
SS1G_01818  tubulin alpha chain [KO:K07374]
SS1G_04652  beta tubulin [KO:K07375]
SS1G_02532  hypothetical protein [KO:K00921] [EC:2.7.1.150]
SS1G_07343  hypothetical protein [KO:K10089]
SS1G_00627  protein transport protein SEC61 alpha subunit [KO:K10956]
SS1G_05902  hypothetical protein [KO:K09481]
SS1G_13172  hypothetical protein [KO:K07342]
SS1G_04685  calreticulin [KO:K08054]
SS1G_11172  conserved hypothetical protein [KO:K21421] [EC:1.-.-.-]
SS1G_13183  hypothetical protein [KO:K04392]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Reference
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
KO pathway
ko04145   

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