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suc02060                    Pathway                                

Phosphotransferase system (PTS) - Staphylococcus aureus subsp. aureus ECT-R 2
The phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) is a major mechanism used by bacteria for uptake of carbohydrates, particularly hexoses, hexitols, and disaccharides, where the source of energy is from PEP. The PTS consists of two general components, enzyme I (EI) and histidine phosphocarrier protein (HPr), and of membrane-bound sugar specific permeases (enzymes II). Each enzyme II (EII) complex consists of one or two hydrophobic integral membrane domains (domains C and D) and two hydrophilic domains (domains A and B). EII complexes may exist as distinct proteins or as a single multidomain protein. The PTS catalyzes the uptake of carbohydrates and their conversion into their respective phosphoesters during transport. There are four successive phosphoryl transfers in the PTS. Initial autophosphorylation of EI, using PEP as a substrate, is followed by transfer of the phosphoryl group from EI to HPr. EIIA catalyzes the self-phosphoryl transfer from HPr after which the phosphoryl group is transferred to histidine or cysteine residues of EIIB. The sugar is transported through the membrane-bound EIIC and is phosphorylated by the appropriate sugar-specific EIIB.
Environmental Information Processing; Membrane transport
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suc02060  Phosphotransferase system (PTS)

Ortholog table
suc_M00266  PTS system, maltose/glucose-specific II component [PATH:suc02060]
suc_M00268  PTS system, alpha-glucoside-specific II component [PATH:suc02060]
suc_M00270  PTS system, trehalose-specific II component [PATH:suc02060]
suc_M00273  PTS system, fructose-specific II component [PATH:suc02060]
suc_M00274  PTS system, mannitol-specific II component [PATH:suc02060]
suc_M00279  PTS system, galactitol-specific II component [PATH:suc02060]
suc_M00281  PTS system, lactose-specific II component [PATH:suc02060]
suc_M00283  PTS system, ascorbate-specific II component [PATH:suc02060]
suc_M00809  PTS system, glucose-specific II component [PATH:suc02060]
Other DBs
BSID: 604243
GO: 0009401
TC: 4.A
Staphylococcus aureus subsp. aureus ECT-R 2 [GN:suc]
ECTR2_939  ptsP; phosphoenolpyruvate-protein phosphotransferase (Phosphotransferase system, enzyme I) [KO:K08483] [EC:]
ECTR2_152  ptsG; PTS system glucose-specific EIICBA component [KO:K20116 K20117 K20118] [EC:]
ECTR2_2390  ptsG; PTS system glucose-specific EIICBA component [KO:K20116 K20117 K20118] [EC:]
ECTR2_1278  ptbA; PTS system glucose-specific EIICBA component [KO:K02777] [EC:2.7.1.-]
ECTR2_1566  nagE; PTS system, N-acetylglucosamine-specific IIBC component [KO:K02803 K02804] [EC:]
ECTR2_203  PTS system maltose-and glucose-specific EIICB component [KO:K02790 K02791] [EC:]
ECTR2_155  phosphotransferase system, EIIC family protein [KO:K02809 K02810] [EC:]
ECTR2_2238  treP; PTS system trehalose-specific EIIBC component [KO:K02809 K02810] [EC:]
ECTR2_226  ptbA; PTS system, glucose subfamily, IIA component domain protein [KO:K02755] [EC:2.7.1.-]
ECTR2_2182  PTS system maltose-specific EIICB component [KO:K02749 K02750] [EC:2.7.1.-]
ECTR2_408  treP; PTS system trehalose-specific EIIBC component [KO:K02818 K02819] [EC:]
ECTR2_2011  mannitol-specific phosphotransferase enzyme IIA component (PTS system mannitol-specific EIIA component) (EIIA-Mtl) (EIII-Mtl) [KO:K02798] [EC:]
ECTR2_2009  mtlA; PTS system mannitol-specific EIICB component [KO:K02799 K02800] [EC:]
ECTR2_2052  lacF; lactose-specific phosphotransferase enzyme IIA component (PTS system lactose-specific EIIA component) (EIIA-Lac) (EIII-Lac) [KO:K02786] [EC:]
ECTR2_2051  PTS system lactose-specific EIICB component [KO:K02787 K02788] [EC:]
ECTR2_206  phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 family protein [KO:K02773] [EC:]
ECTR2_207  PTS system, Lactose/Cellobiose specific IIB subunit [KO:K02774] [EC:]
ECTR2_208  putative phosphotransferase D-arabitol specific component IIC [KO:K02775]
ECTR2_291  phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 family protein [KO:K02821] [EC:]
ECTR2_290  PTS system, Lactose/Cellobiose specific IIB subunit [KO:K02822] [EC:]
ECTR2_289  sugar-specific permease, SgaT/UlaA family protein [KO:K03475]
ECTR2_651  fruA; IIABC fructose/xylitol-PTS [KO:K02768 K02769 K02770] [EC:]
ECTR2_2495  PTS system, Fru family, IIB component domain protein [KO:K02768 K02769 K02770] [EC:]
C00022  Pyruvate
C00031  D-Glucose
C00072  Ascorbate
C00074  Phosphoenolpyruvate
C00089  Sucrose
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00124  D-Galactose
C00140  N-Acetyl-D-glucosamine
C00159  D-Mannose
C00185  Cellobiose
C00208  Maltose
C00243  Lactose
C00275  D-Mannose 6-phosphate
C00329  D-Glucosamine
C00352  D-Glucosamine 6-phosphate
C00357  N-Acetyl-D-glucosamine 6-phosphate
C00392  Mannitol
C00644  D-Mannitol 1-phosphate
C00689  alpha,alpha'-Trehalose 6-phosphate
C00697  Nitrogen
C00794  D-Sorbitol
C01083  alpha,alpha-Trehalose
C01094  D-Fructose 1-phosphate
C01096  Sorbitol 6-phosphate
C01113  D-Galactose 6-phosphate
C01132  N-Acetyl-D-galactosamine
C01451  Salicin
C01452  Sorbose
C01674  Chitobiose
C01697  Galactitol
C01798  D-Glucoside
C02262  D-Galactosamine
C02713  N-Acetylmuramate
C02888  Sorbose 1-phosphate
C02995  Maltose 6'-phosphate
C03752  2-Amino-2-deoxy-D-gluconate
C04534  6-Phospho-beta-D-glucosyl-(1,4)-D-glucose
C05396  Lactose 6'-phosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C06311  Galactitol 1-phosphate
C06376  N-Acetyl-D-galactosamine 6-phosphate
C06377  D-Galactosamine 6-phosphate
C11544  2-O-(alpha-D-Mannosyl)-D-glycerate
C16186  L-Ascorbate 6-phosphate
C16488  Fructoselysine
C16489  Fructoselysine 6-phosphate
C16688  Sucrose 6-phosphate
C16698  N-Acetylmuramic acid 6-phosphate
C16699  2-O-(6-Phospho-alpha-mannosyl)-D-glycerate
C20589  D-Glucosaminate-6-phosphate
C20978  Glucoselysine
C20979  Glucoselysine-6-phosphate
C21152  N,N'-Diacetylchitobiose 6'-phosphate
Darbon E, Galinier A, Le Coq D, Deutscher J.
Phosphotransfer functions mutated Bacillus subtilis HPr-like protein Crh carrying a histidine in the active site.
J Mol Microbiol Biotechnol 3:439-44 (2001)
Dahl U, Jaeger T, Nguyen BT, Sattler JM, Mayer C.
Identification of a phosphotransferase system of Escherichia coli required for growth on N-acetylmuramic acid.
J Bacteriol 186:2385-92 (2004)
Martin-Verstraete I, Debarbouille M, Klier A, Rapoport G
Levanase operon of Bacillus subtilis includes a fructose-specific phosphotransferase system regulating the expression of the operon.
J Mol Biol 214:657-71 (1990)
Kristich CJ, Glekas GD, Ordal GW.
The conserved cytoplasmic module of the transmembrane chemoreceptor McpC mediates carbohydrate chemotaxis in Bacillus subtilis.
Mol Microbiol 47:1353-66 (2003)
Sampaio MM, Chevance F, Dippel R, Eppler T, Schlegel A, Boos W, Lu YJ, Rock CO.
Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor.
J Biol Chem 279:5537-48 (2004)
Keseler IM, Collado-Vides J, Gama-Castro S, Ingraham J, Paley S, Paulsen IT, Peralta-Gil M, Karp PD.
EcoCyc: a comprehensive database resource for Escherichia coli.
Nucleic Acids Res 33:D334-7 (2005)
Mukherjee A, Mammel MK, LeClerc JE, Cebula TA.
Altered utilization of N-acetyl-D-galactosamine by Escherichia coli O157:H7 from the 2006 spinach outbreak.
J Bacteriol 190:1710-7 (2008)
Brinkkotter A, Kloss H, Alpert C, Lengeler JW.
Pathways for the utilization of N-acetyl-galactosamine and galactosamine in Escherichia coli.
Mol Microbiol 37:125-35 (2000)
Tchieu JH, Norris V, Edwards JS, Saier MH Jr.
The complete phosphotranferase system in Escherichia coli.
J Mol Microbiol Biotechnol 3:329-46 (2001)
Kotrba P, Inui M, Yukawa H.
Bacterial phosphotransferase system (PTS) in carbohydrate uptake and control of carbon metabolism.
J Biosci Bioeng 92:502-17 (2001)
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