KEGG   PATHWAY: swi00760Help
Entry
swi00760                    Pathway                                

Name
Nicotinate and nicotinamide metabolism - Sphingomonas wittichii
Class
Metabolism; Metabolism of cofactors and vitamins
BRITE hierarchy
Pathway map
swi00760  Nicotinate and nicotinamide metabolism
swi00760

Ortholog table
Module
swi_M00115  NAD biosynthesis, aspartate => NAD [PATH:swi00760]
Other DBs
BSID: 53298
UMBBD: nic
GO: 0006769
Organism
Sphingomonas wittichii [GN:swi]
Gene
Swit_1927  L-aspartate oxidase [KO:K00278] [EC:1.4.3.16]
Swit_4715  quinolinate synthetase A [KO:K03517] [EC:2.5.1.72]
Swit_4716  nicotinate-nucleotide pyrophosphorylase (carboxylating) [KO:K00767] [EC:2.4.2.19]
Swit_0638  3'-nucleotidase / 5'-nucleotidase / exopolyphosphatase [KO:K03787] [EC:3.1.3.5]
Swit_2543  cytidylyltransferase [KO:K00969] [EC:2.7.7.18]
Swit_0253  MazG family protein [KO:K04765] [EC:3.6.1.9]
Swit_4689  NUDIX hydrolase [KO:K03426] [EC:3.6.1.22]
Swit_2595  NAD(+) synthase (glutamine-hydrolyzing) [KO:K01950] [EC:6.3.5.1]
Swit_0243  CinA domain protein [KO:K03743] [EC:3.5.1.42]
Swit_1521  NAD(+) kinase [KO:K00858] [EC:2.7.1.23]
Swit_1182  NAD/NADP transhydrogenase alpha subunit-like protein [KO:K00324] [EC:1.6.1.2]
Swit_1183  alanine dehydrogenase/PNT domain protein [KO:K00324] [EC:1.6.1.2]
Swit_1181  NAD(P)(+) transhydrogenase (AB-specific) [KO:K00325] [EC:1.6.1.2]
Swit_0831  Asp/Glu racemase [KO:K01799] [EC:5.2.1.1]
Swit_1568  succinate semialdehyde dehydrogenase [KO:K00135] [EC:1.2.1.20 1.2.1.79 1.2.1.16]
Swit_4212  succinate semialdehyde dehydrogenase [KO:K00135] [EC:1.2.1.20 1.2.1.79 1.2.1.16]
Swit_3067  succinate semialdehyde dehydrogenase [KO:K00135] [EC:1.2.1.20 1.2.1.79 1.2.1.16]
Swit_4158  succinate semialdehyde dehydrogenase [KO:K00135] [EC:1.2.1.20 1.2.1.79 1.2.1.16]
Swit_4306  succinate semialdehyde dehydrogenase [KO:K00135] [EC:1.2.1.20 1.2.1.79 1.2.1.16]
Compound
C00003  NAD+
C00006  NADP+
C00022  Pyruvate
C00042  Succinate
C00049  L-Aspartate
C00111  Glycerone phosphate
C00122  Fumarate
C00153  Nicotinamide
C00163  Propanoate
C00232  Succinate semialdehyde
C00253  Nicotinate
C00334  4-Aminobutanoate
C00455  Nicotinamide D-ribonucleotide
C00857  Deamino-NAD+
C00922  2,3-Dimethylmaleate
C01004  N-Methylnicotinate
C01020  6-Hydroxynicotinate
C01056  (S)-6-Hydroxynicotine
C01059  2,5-Dihydroxypyridine
C01185  Nicotinate D-ribonucleotide
C01297  6-Hydroxypseudooxynicotine
C01384  Maleic acid
C01596  Maleamate
C02295  Methylitaconate
C02918  1-Methylnicotinamide
C02930  2-Methyleneglutarate
C03043  (R)-6-Hydroxynicotine
C03056  2,6-Dihydroxypyridine
C03150  Nicotinamide-beta-riboside
C03458  2,3,6-Trihydroxypyridine
C03652  (2R,3S)-2,3-Dimethylmalate
C03722  Quinolinate
C04226  6-Oxo-1,4,5,6-tetrahydronicotinate
C05380  Nicotinurate
C05840  Iminoaspartate
C05841  Nicotinate D-ribonucleoside
C05842  N1-Methyl-2-pyridone-5-carboxamide
C05843  N1-Methyl-4-pyridone-5-carboxamide
C06178  1-Methylpyrrolinium
C15523  2,6-Dihydroxynicotinate
C15986  2,6-Dihydroxypseudooxynicotine
C15987  4-Methylaminobutyrate
C16150  (R,S)-Nicotine
C16151  2,6-Dihydroxy-N-methylmyosmine
C16152  Blue pigment
C16159  2-Formylglutarate
C16390  (S)-2-(Hydroxymethyl)glutarate
C18232  N-Formylmaleamic acid
C19567  4-Oxo-1-(3-pyridyl)-1-butanone
C19569  3-Succinoylpyridine
C19631  6-Hydroxy-3-succinoylpyridine
C20361  Pseudooxynicotine
C20381  3,3'-Bipyridine-2,2',5,5',6,6'-hexol
C21075  5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol
C21154  N-Methylmyosmine
Reference
  Authors
BEHRMAN EJ, STANIER RY.
  Title
The bacterial oxidation of nicotinic acid.
  Journal
J Biol Chem 228:923-45 (1957)
Reference
  Authors
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  Title
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  Journal
Proc Natl Acad Sci U S A 103:12341-6 (2006)
DOI:10.1073/pnas.0601635103
Reference
  Authors
Baitsch D, Sandu C, Brandsch R, Igloi GL.
  Title
Gene cluster on pAO1 of Arthrobacter nicotinovorans involved in degradation of the plant alkaloid nicotine: cloning, purification, and characterization of 2,6-dihydroxypyridine 3-hydroxylase.
  Journal
J Bacteriol 183:5262-7 (2001)
DOI:10.1128/JB.183.18.5262-5267.2001
Reference
  Authors
Sachelaru P, Schiltz E, Igloi GL, Brandsch R.
  Title
An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.
  Journal
J Bacteriol 187:8516-9 (2005)
DOI:10.1128/JB.187.24.8516-8519.2005
Reference
PMID:5835946
  Authors
Gherna RL, Richardson SH, Rittenberg SC
  Title
The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine.
  Journal
J Biol Chem 240:3669-74 (1965)
Reference
  Authors
Galeazzi L, Bocci P, Amici A, Brunetti L, Ruggieri S, Romine M, Reed S, Osterman AL, Rodionov DA, Sorci L, Raffaelli N
  Title
Identification of nicotinamide mononucleotide deamidase of the bacterial pyridine nucleotide cycle reveals a novel broadly conserved amidohydrolase family.
  Journal
J Biol Chem 286:40365-75 (2011)
DOI:10.1074/jbc.M111.275818
KO pathway
ko00760   

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