KEGG   PATHWAY: swp03440
Entry
swp03440                    Pathway                                
Name
Homologous recombination - Shewanella piezotolerans
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
swp03440  Homologous recombination
swp03440

Other DBs
GO: 0000724
Organism
Shewanella piezotolerans [GN:swp]
Gene
swp_4226  RecJ exonuclease [KO:K07462] [EC:3.1.-.-]
swp_4531  Single-strand binding protein [KO:K03111]
swp_0017  DNA replication and repair protein RecF [KO:K03629]
swp_3778  Recombination protein O, RecO [KO:K03584]
swp_1731  Recombination protein RecR [KO:K06187]
swp_1366  RecA bacterial DNA recombination protein [KO:K03553]
swp_5074  DNA polymerase A [KO:K02335] [EC:2.7.7.7]
swp_2354  DNA recombination protein, RuvA [KO:K03550]
swp_2355  Holliday junction DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
swp_2353  Crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.21.10]
swp_0309  ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
swp_2768  Exodeoxyribonuclease V, beta subunit [KO:K03582] [EC:3.1.11.5]
swp_2767  Exodeoxyribonuclease V, RecC subunit [KO:K03583] [EC:3.1.11.5]
swp_2769  Exodeoxyribonuclease V, alpha subunit [KO:K03581] [EC:3.1.11.5]
swp_3506  DNA polymerase III alpha subunit [KO:K02337] [EC:2.7.7.7]
swp_0016  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
swp_1716  DNA-directed DNA polymerase [KO:K02343] [EC:2.7.7.7]
swp_3917  DNA polymerase III, delta [KO:K02340] [EC:2.7.7.7]
swp_2831  DNA-directed DNA polymerase [KO:K02341] [EC:2.7.7.7]
swp_2303  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
swp_3319  Exonuclease [KO:K02342] [EC:2.7.7.7]
swp_2688  DNA polymerase III [KO:K02342] [EC:2.7.7.7]
swp_1976  Exonuclease [KO:K02342] [EC:2.7.7.7]
swp_0906  DNA polymerase III chi subunit, HolC [KO:K02339] [EC:2.7.7.7]
swp_0475  Primosomal protein n [KO:K04066] [EC:5.6.2.4]
swp_0712  Primosomal replication protein n [KO:K02686]
swp_3216  Primosomal replication protein N'', putative [KO:K04067]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG GENES (27)   
All databases (28)   

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