KEGG   PATHWAY: tgo04145Help
Entry
tgo04145                    Pathway                                

Name
Phagosome - Toxoplasma gondii
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
tgo04145  Phagosome
tgo04145

Ortholog table
Other DBs
BSID: 153992
GO: 0045335
Organism
Toxoplasma gondii [GN:tgo]
Gene
TGME49_270070  synaptobrevin family protein [KO:K08517]
TGME49_256970  vacuolar ATP synthase subunit A, putative [KO:K02145] [EC:3.6.3.14]
TGME49_219800  vacuolar ATP synthase subunit b, putative [KO:K02147]
TGME49_315620  vacuolar ATP synthase subunit C, putative [KO:K02148]
TGME49_281920  V-type ATPase, D subunit protein [KO:K02149]
TGME49_246560  vacuolar ATP synthase subunit g, putative [KO:K02152]
TGME49_232830  vacuolar proton translocating ATPase subunit A, putative [KO:K02154]
TGME49_259010  vacuolar ATP synthase subunit d, putative [KO:K02146]
TGME49_208590  vacuolar ATP synthase subunit 54kD, putative [KO:K02144]
TGME49_291310  V-ATPase subunit c' proteolipid, putative [KO:K03661]
TGME49_248880  RAB7; GTPase RAB7 [KO:K07897]
TGME49_294550  dynein heavy chain [KO:K10413]
TGME49_316400  TUBA1; alpha tubulin TUBA1 [KO:K07374]
TGME49_231400  tubulin/FtsZ family, GTPase domain-containing protein [KO:K07374]
TGME49_231770  alpha-tubulin I, putative [KO:K07374]
TGME49_212240  beta-1 tubulin, putative [KO:K07375]
TGME49_266960  beta tubulin [KO:K07375]
TGME49_221620  beta-tubulin, putative [KO:K07375]
TGME49_269980  preprotein translocase Sec61, putative [KO:K10956]
TGME49_211040  Sec61beta family protein [KO:K09481]
TGME49_310320  calreticulin family protein [KO:K08054]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Reference
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
KO pathway
ko04145   

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