KEGG   PATHWAY: tme03440Help
Entry
tme03440                    Pathway                                

Name
Homologous recombination - Thermosipho melanesiensis
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
tme03440  Homologous recombination
tme03440

Ortholog table
Module
tme_M00260  DNA polymerase III complex, bacteria [PATH:tme03440]
Other DBs
BSID: 54426
GO: 0000724
Organism
Thermosipho melanesiensis [GN:tme]
Gene
Tmel_0301  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
Tmel_0637  single-strand binding protein [KO:K03111]
Tmel_1158  recA protein [KO:K03553]
Tmel_1917  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
Tmel_0911  Holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
Tmel_1538  Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
Tmel_1038  crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.22.4]
Tmel_0034  ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
Tmel_1524  DNA-directed DNA polymerase [KO:K02337] [EC:2.7.7.7]
Tmel_1039  DNA polymerase III, alpha subunit [KO:K03763] [EC:2.7.7.7]
Tmel_0535  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
Tmel_1397  DNA polymerase III, subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
Tmel_1151  DNA polymerase III, delta [KO:K02340] [EC:2.7.7.7]
Tmel_1899  DNA polymerase III gamma/tau subunits-like protein [KO:K02341] [EC:2.7.7.7]
Tmel_0478  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Tmel_0276  primosomal protein N' [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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