KEGG   PATHWAY: tml03440
Entry
tml03440                    Pathway                                
Name
Homologous recombination - Tuber melanosporum
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
tml03440  Homologous recombination
tml03440

Other DBs
GO: 0000724
Organism
Tuber melanosporum [GN:tml]
Gene
GSTUM_00001634001  hypothetical protein [KO:K10866] [EC:3.6.-.-]
GSTUM_00004321001  hypothetical protein [KO:K10865]
GSTUM_00007669001  hypothetical protein [KO:K04728] [EC:2.7.11.1]
GSTUM_00003253001  hypothetical protein [KO:K10881]
GSTUM_00009344001  hypothetical protein [KO:K10958]
GSTUM_00005528001  hypothetical protein [KO:K07466]
GSTUM_00003154001  hypothetical protein [KO:K10739]
GSTUM_00002392001  hypothetical protein [KO:K04482]
GSTUM_00010491001  hypothetical protein [KO:K10873]
GSTUM_00000296001  hypothetical protein [KO:K10875] [EC:5.6.2.-]
GSTUM_00003008001  hypothetical protein [KO:K10877] [EC:5.6.2.-]
GSTUM_00008021001  hypothetical protein [KO:K02327] [EC:2.7.7.7]
GSTUM_00008900001  hypothetical protein [KO:K02328]
GSTUM_00002952001  hypothetical protein [KO:K03504]
GSTUM_00009250001  hypothetical protein [KO:K03504]
GSTUM_00005673001  hypothetical protein [KO:K03165] [EC:5.6.2.1]
GSTUM_00006347001  hypothetical protein [KO:K08991] [EC:3.1.22.-]
GSTUM_00010921001  hypothetical protein [KO:K10882] [EC:3.1.22.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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