KEGG   PATHWAY: tmu03040
Entry
tmu03040                    Pathway                                
Name
Spliceosome - Trichechus manatus latirostris (Florida manatee)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
tmu03040  Spliceosome
tmu03040

Other DBs
GO: 0005681
Organism
Trichechus manatus latirostris (Florida manatee) [GN:tmu]
Gene
111819405  U1 spliceosomal RNA [KO:K14276]
111820879  U1 spliceosomal RNA [KO:K14276]
111819447  U1 spliceosomal RNA [KO:K14276]
111819341  U1 spliceosomal RNA [KO:K14276]
111820335  U1 spliceosomal RNA [KO:K14276]
111819181  U2 spliceosomal RNA [KO:K14277]
111821886  U2 spliceosomal RNA [KO:K14277]
111821671  U2 spliceosomal RNA [KO:K14277]
111821192  U2 spliceosomal RNA [KO:K14277]
111821895  U2 spliceosomal RNA [KO:K14277]
111819620  U2 spliceosomal RNA [KO:K14277]
111821745  U2 spliceosomal RNA [KO:K14277]
111821052  U4 spliceosomal RNA [KO:K14278]
111820925  U4 spliceosomal RNA [KO:K14278]
111821054  U4 spliceosomal RNA [KO:K14278]
111819899  U5 spliceosomal RNA [KO:K14279]
111819686  U5 spliceosomal RNA [KO:K14279]
111820246  U5 spliceosomal RNA [KO:K14279]
111820247  U5 spliceosomal RNA [KO:K14279]
111821717  U5 spliceosomal RNA [KO:K14279]
111821352  U5 spliceosomal RNA [KO:K14279]
111819102  U6 spliceosomal RNA [KO:K14280]
111822685  U6 spliceosomal RNA [KO:K14280]
111820248  U6 spliceosomal RNA [KO:K14280]
111822102  U6 spliceosomal RNA [KO:K14280]
111819190  U6 spliceosomal RNA [KO:K14280]
111820317  U6 spliceosomal RNA [KO:K14280]
111821417  U6 spliceosomal RNA [KO:K14280]
111821003  U6 spliceosomal RNA [KO:K14280]
111819785  U6 spliceosomal RNA [KO:K14280]
111820800  U6 spliceosomal RNA [KO:K14280]
111820913  U6 spliceosomal RNA [KO:K14280]
111819614  U6 spliceosomal RNA [KO:K14280]
111820592  U6 spliceosomal RNA [KO:K14280]
111821384  U6 spliceosomal RNA [KO:K14280]
111819752  U6 spliceosomal RNA [KO:K14280]
111819387  U6 spliceosomal RNA [KO:K14280]
111820020  U6 spliceosomal RNA [KO:K14280]
111819178  U6 spliceosomal RNA [KO:K14280]
111819765  U6 spliceosomal RNA [KO:K14280]
111819276  U6 spliceosomal RNA [KO:K14280]
111822752  U6 spliceosomal RNA [KO:K14280]
111819900  U6 spliceosomal RNA [KO:K14280]
111820643  U6 spliceosomal RNA [KO:K14280]
111821019  U6 spliceosomal RNA [KO:K14280]
111819841  U6 spliceosomal RNA [KO:K14280]
111819140  U6 spliceosomal RNA [KO:K14280]
111822068  U6 spliceosomal RNA [KO:K14280]
111821354  U6 spliceosomal RNA [KO:K14280]
111819480  U6 spliceosomal RNA [KO:K14280]
111820914  U6 spliceosomal RNA [KO:K14280]
111821569  U6 spliceosomal RNA [KO:K14280]
111822798  U6 spliceosomal RNA [KO:K14280]
111821858  U6 spliceosomal RNA [KO:K14280]
111821501  U6 spliceosomal RNA [KO:K14280]
111820729  U6 spliceosomal RNA [KO:K14280]
111820915  U6 spliceosomal RNA [KO:K14280]
111822847  U6 spliceosomal RNA [KO:K14280]
111819592  U6 spliceosomal RNA [KO:K14280]
111820768  U6 spliceosomal RNA [KO:K14280]
111822719  U6 spliceosomal RNA [KO:K14280]
111820862  U6 spliceosomal RNA [KO:K14280]
111820137  U6 spliceosomal RNA [KO:K14280]
111819989  U6 spliceosomal RNA [KO:K14280]
111821114  U6 spliceosomal RNA [KO:K14280]
111820763  U6 spliceosomal RNA [KO:K14280]
111820285  U6 spliceosomal RNA [KO:K14280]
111822411  U6 spliceosomal RNA [KO:K14280]
111819726  U6 spliceosomal RNA [KO:K14280]
111822440  U6 spliceosomal RNA [KO:K14280]
101348122  probable ATP-dependent RNA helicase DDX46 isoform X2 [KO:K12811] [EC:5.6.2.7]
101341139  spliceosome RNA helicase DDX39B isoform X1 [KO:K12812] [EC:5.6.2.7]
101361746  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [KO:K12813] [EC:5.6.2.6]
101357164  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 isoform X1 [KO:K12815] [EC:5.6.2.6]
101358734  pre-mRNA-processing factor 17 isoform X1 [KO:K12816]
101348615  pre-mRNA-splicing factor 18 isoform X3 [KO:K12817]
101356205  ATP-dependent RNA helicase DHX8 isoform X1 [KO:K12818] [EC:5.6.2.6]
101342221  pre-mRNA-splicing factor SLU7 [KO:K12819]
101362020  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [KO:K12820] [EC:5.6.2.6]
101340317  small nuclear ribonucleoprotein-associated proteins B and B' isoform X1 [KO:K11086]
101354296  small nuclear ribonucleoprotein Sm D1 [KO:K11087]
101357058  small nuclear ribonucleoprotein Sm D2 isoform X1 [KO:K11096]
101350916  small nuclear ribonucleoprotein Sm D3 [KO:K11088]
101355514  small nuclear ribonucleoprotein E [KO:K11097]
101345555  small nuclear ribonucleoprotein F [KO:K11098]
101359765  small nuclear ribonucleoprotein G [KO:K11099]
101354529  U1 small nuclear ribonucleoprotein 70 kDa isoform X1 [KO:K11093]
101352765  U1 small nuclear ribonucleoprotein A [KO:K11091]
101358374  U1 small nuclear ribonucleoprotein C [KO:K11095]
101352449  pre-mRNA-processing factor 40 homolog A isoform X2 [KO:K12821]
101356341  pre-mRNA-processing factor 40 homolog B isoform X1 [KO:K12821]
101346882  RNA-binding protein 25 isoform X2 [KO:K12822]
101351668  probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
101348635  transcription elongation regulator 1 isoform X1 [KO:K12824]
101357666  RNA-binding protein FUS isoform X1 [KO:K13098]
101351575  U2 small nuclear ribonucleoprotein A' [KO:K11092]
101340294  U2 small nuclear ribonucleoprotein B'' [KO:K11094]
101360678  splicing factor 3A subunit 1 [KO:K12825]
101349631  splicing factor 3A subunit 2 [KO:K12826]
101341305  splicing factor 3A subunit 3 [KO:K12827]
101357717  splicing factor 3B subunit 1 isoform X2 [KO:K12828]
101356060  splicing factor 3B subunit 2 [KO:K12829]
101341613  splicing factor 3B subunit 3 isoform X1 [KO:K12830]
101356433  splicing factor 3B subunit 4 [KO:K12831]
101359673  splicing factor 3B subunit 5 [KO:K12832]
101348008  splicing factor 3B subunit 6 [KO:K12833]
101351481  PHD finger-like domain-containing protein 5A [KO:K12834]
101354248  ATP-dependent RNA helicase DDX42 isoform X1 [KO:K12835] [EC:5.6.2.7]
101351882  splicing factor U2AF 35 kDa subunit isoform X1 [KO:K12836]
101348560  splicing factor U2AF 26 kDa subunit [KO:K12836]
101361795  splicing factor U2AF 65 kDa subunit isoform X2 [KO:K12837]
101356758  poly(U)-binding-splicing factor PUF60 isoform X1 [KO:K12838]
101342237  survival of motor neuron-related-splicing factor 30 isoform X1 [KO:K12839]
101357055  splicing factor 45 isoform X1 [KO:K12840]
101351619  calcium homeostasis endoplasmic reticulum protein [KO:K12841]
101362063  U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842]
101344664  retinitis pigmentosa 9 protein isoform X2 [KO:K19604]
101358726  U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
101340864  U6 snRNA-associated Sm-like protein LSm3 isoform X2 [KO:K12622]
101342777  U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
101346333  U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
101351941  U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
101361098  U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
101343403  LSM8 homolog, U6 small nuclear RNA associated [KO:K12627]
101352847  U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843]
101360302  U4/U6 small nuclear ribonucleoprotein Prp4 [KO:K12662]
101347576  peptidyl-prolyl cis-trans isomerase H isoform X1 [KO:K09567] [EC:5.2.1.8]
101352036  U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
101361106  NHP2-like protein 1 [KO:K12845]
101340257  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
101361397  U4/U6.U5 tri-snRNP-associated protein 2 [KO:K12847]
101356820  U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
101349813  zinc finger matrin-type protein 2 [KO:K12848]
101357776  pre-mRNA-splicing factor 38A [KO:K12849]
101352319  pre-mRNA-splicing factor 38B isoform X1 [KO:K12850]
101346128  116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
101345164  U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
101358019  pre-mRNA-processing factor 6 [KO:K12855]
101341155  pre-mRNA-processing-splicing factor 8 [KO:K12856]
101342309  U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
101350419  probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
101353855  thioredoxin-like protein 4A isoform X1 [KO:K12859]
101360286  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
101345121  cell division cycle 5-like protein [KO:K12860]
101345468  pre-mRNA-splicing factor SPF27 isoform X1 [KO:K12861]
101349068  LOW QUALITY PROTEIN: pleiotropic regulator 1-like [KO:K12862]
101342336  pleiotropic regulator 1 isoform X2 [KO:K12862]
101347455  spliceosome-associated protein CWC15 homolog [KO:K12863]
101341041  beta-catenin-like protein 1 isoform X1 [KO:K12864]
101348660  heat shock 70 kDa protein 1-like [KO:K03283]
101354728  heat shock cognate 71 kDa protein [KO:K03283]
101351001  heat shock 70 kDa protein 6 [KO:K03283]
101356837  LOW QUALITY PROTEIN: heat shock 70 kDa protein-like [KO:K03283]
101356536  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
101348919  heat shock 70 kDa protein 1 [KO:K03283]
101357110  heat shock 70 kDa protein 1 [KO:K03283]
101346309  polyglutamine-binding protein 1 [KO:K12865]
101341435  WW domain-binding protein 11 [KO:K12866]
101342219  SNW domain-containing protein 1 isoform X2 [KO:K06063]
101345037  pre-mRNA-splicing factor SYF1 isoform X1 [KO:K12867]
101345883  pre-mRNA-splicing factor SYF2 isoform X1 [KO:K12868]
101355864  crooked neck-like protein 1 [KO:K12869]
101351638  pre-mRNA-splicing factor ISY1 homolog isoform X2 [KO:K12870]
101342505  peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
101357108  peptidyl-prolyl cis-trans isomerase E isoform X1 [KO:K09564] [EC:5.2.1.8]
101361649  coiled-coil domain-containing protein 12 [KO:K12871]
101357239  pre-mRNA-splicing factor RBM22 [KO:K12872]
101350404  protein BUD31 homolog [KO:K12873]
101348445  LOW QUALITY PROTEIN: intron-binding protein aquarius [KO:K12874]
101343564  apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
101344118  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
101352282  RNA-binding protein 8A [KO:K12876]
101347989  protein mago nashi homolog 2 [KO:K12877]
101355072  protein mago nashi homolog [KO:K12877]
101341542  THO complex subunit 1 [KO:K12878]
101345896  THO complex subunit 2 isoform X5 [KO:K12879]
101348072  THO complex subunit 3 [KO:K12880]
101340286  THO complex subunit 4 [KO:K12881]
101340800  nuclear cap-binding protein subunit 1 isoform X4 [KO:K12882]
101354323  nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
101342740  heterogeneous nuclear ribonucleoprotein A1 isoform X4 [KO:K12741]
101357038  heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741]
101352714  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
101352952  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X4 [KO:K12884]
101353830  RNA-binding motif protein, X chromosome [KO:K12885]
101341169  heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
101349201  heterogeneous nuclear ribonucleoprotein M isoform X1 [KO:K12887]
101354506  heterogeneous nuclear ribonucleoprotein U isoform X1 [KO:K12888]
101361402  poly(rC)-binding protein 1 [KO:K12889]
101342250  serine/arginine-rich splicing factor 1 isoform X1 [KO:K12890]
101352615  serine/arginine-rich splicing factor 2 [KO:K12891]
101358788  serine/arginine-rich splicing factor 2-like [KO:K12891]
101341748  serine/arginine-rich splicing factor 3 [KO:K12892]
101358282  serine/arginine-rich splicing factor 6 [KO:K12893]
101340685  serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
101353150  serine/arginine-rich splicing factor 4 isoform X2 [KO:K12893]
101360893  serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
101357976  serine/arginine-rich splicing factor 9 [KO:K21123]
101354854  transformer-2 protein homolog beta isoform X1 [KO:K12897]
101358579  transformer-2 protein homolog alpha isoform X1 [KO:K12897]
101354081  serine/arginine-rich splicing factor 10 isoform X1 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   

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Genome (1)   
   KEGG GENOME (1)   
Gene (201)   
   KEGG GENES (201)   
All databases (202)   

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