KEGG   PATHWAY: tup00350
Entry
tup00350                    Pathway                                
Name
Tyrosine metabolism - Tupaia chinensis (Chinese tree shrew)
Class
Metabolism; Amino acid metabolism
Pathway map
tup00350  Tyrosine metabolism
tup00350

Module
tup_M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline [PATH:tup00350]
tup_M00043  Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine [PATH:tup00350]
tup_M00044  Tyrosine degradation, tyrosine => homogentisate [PATH:tup00350]
Other DBs
GO: 0006570
Organism
Tupaia chinensis (Chinese tree shrew) [GN:tup]
Gene
102497034  GOT1; glutamic-oxaloacetic transaminase 1 [KO:K14454] [EC:2.6.1.1]
102489665  GOT1L1; glutamic-oxaloacetic transaminase 1-like 1 [KO:K14454] [EC:2.6.1.1]
102474780  GOT2; glutamic-oxaloacetic transaminase 2 [KO:K14455] [EC:2.6.1.1]
102487558  TAT; tyrosine aminotransferase [KO:K00815] [EC:2.6.1.5]
102481575  L-amino-acid oxidase [KO:K03334] [EC:1.4.3.2]
102484685  IL4I1; interleukin 4 induced 1 [KO:K03334] [EC:1.4.3.2]
102486848  HPD; 4-hydroxyphenylpyruvate dioxygenase [KO:K00457] [EC:1.13.11.27]
102497510  HGD; homogentisate 1,2-dioxygenase [KO:K00451] [EC:1.13.11.5]
102471045  GSTZ1; glutathione S-transferase zeta 1 [KO:K01800] [EC:5.2.1.2]
102488596  FAH; fumarylacetoacetate hydrolase [KO:K01555] [EC:3.7.1.2]
102485831  TYR; tyrosinase [KO:K00505] [EC:1.14.18.1]
102482570  TH; tyrosine hydroxylase [KO:K00501] [EC:1.14.16.2]
102484655  DCT; dopachrome tautomerase [KO:K01827] [EC:5.3.3.12]
102498188  TYRP1; tyrosinase related protein 1 [KO:K00506] [EC:1.14.18.-]
102499553  DDC; dopa decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
102468703  DBH; dopamine beta-hydroxylase [KO:K00503] [EC:1.14.17.1]
102501155  PNMT; phenylethanolamine N-methyltransferase [KO:K00553] [EC:2.1.1.28]
102485737  COMT; catechol-O-methyltransferase [KO:K00545] [EC:2.1.1.6]
102500221  transmembrane O-methyltransferase [KO:K00545] [EC:2.1.1.6]
102479142  MAOB; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
102479553  MAOA; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
102490650  AOC2; amine oxidase, copper containing 2 [KO:K00276] [EC:1.4.3.21]
102491763  membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]
102491341  AOC3; amine oxidase, copper containing 3 [KO:K00276] [EC:1.4.3.21]
102475132  aldehyde dehydrogenase family 3 member B1 [KO:K00129] [EC:1.2.1.5]
102490907  ALDH3A1; aldehyde dehydrogenase 3 family member A1 [KO:K00129] [EC:1.2.1.5]
102474716  ALDH3B1; aldehyde dehydrogenase family 3 member B1 [KO:K00129] [EC:1.2.1.5]
102484756  alcohol dehydrogenase E chain [KO:K13951] [EC:1.1.1.1]
102493658  ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [KO:K13951] [EC:1.1.1.1]
102483916  ADH4; alcohol dehydrogenase 4 [KO:K13980] [EC:1.1.1.1]
102485893  ADH5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
102494070  ADH6; alcohol dehydrogenase 6 [KO:K13952] [EC:1.1.1.1]
102498362  TPO; thyroid peroxidase [KO:K00431] [EC:1.11.1.8]
102482260  aldehyde oxidase [KO:K00157] [EC:1.2.3.1]
102484619  AOX1; aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
102490052  aldehyde oxidase 4 [KO:K00157] [EC:1.2.3.1]
102484426  FAHD1; fumarylacetoacetate hydrolase domain containing 1 [KO:K01557] [EC:3.7.1.5]
102496819  acylpyruvase FAHD1, mitochondrial [KO:K01557] [EC:3.7.1.5]
102489547  MIF; macrophage migration inhibitory factor (glycosylation-inhibiting factor) [KO:K07253] [EC:5.3.2.1]
Compound
C00022  Pyruvate
C00042  Succinate
C00082  L-Tyrosine
C00122  Fumarate
C00146  Phenol
C00164  Acetoacetate
C00232  Succinate semialdehyde
C00355  3,4-Dihydroxy-L-phenylalanine
C00483  Tyramine
C00530  Hydroquinone
C00544  Homogentisate
C00547  L-Noradrenaline
C00628  2,5-Dihydroxybenzoate
C00642  4-Hydroxyphenylacetate
C00788  L-Adrenaline
C00811  4-Coumarate
C00822  Dopaquinone
C01036  4-Maleylacetoacetate
C01060  3,5-Diiodo-L-tyrosine
C01061  4-Fumarylacetoacetate
C01161  3,4-Dihydroxyphenylacetate
C01179  3-(4-Hydroxyphenyl)pyruvate
C01384  Maleic acid
C01693  L-Dopachrome
C01829  Thyroxine
C01850  Rosmarinate
C02167  Maleylpyruvate
C02442  N-Methyltyramine
C02465  Triiodothyronine
C02514  3-Fumarylpyruvate
C02515  3-Iodo-L-tyrosine
C03063  2-Oxohept-3-enedioate
C03077  4-Chlorophenylacetate
C03758  Dopamine
C03765  4-Hydroxyphenylacetaldehyde
C03964  (R)-3-(4-Hydroxyphenyl)lactate
C04043  3,4-Dihydroxyphenylacetaldehyde
C04045  3-(3,4-Dihydroxyphenyl)pyruvate
C04052  5-Carboxy-2-oxohept-3-enedioate
C04185  5,6-Dihydroxyindole-2-carboxylate
C04186  5-Carboxymethyl-2-hydroxymuconate
C04368  3-Amino-3-(4-hydroxyphenyl)propanoate
C04642  2-Hydroxy-5-carboxymethylmuconate semialdehyde
C04796  4-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C04797  5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C05338  4-Hydroxyphenylacetyl-CoA
C05350  2-Hydroxy-3-(4-hydroxyphenyl)propenoate
C05576  3,4-Dihydroxyphenylethyleneglycol
C05577  3,4-Dihydroxymandelaldehyde
C05578  5,6-Dihydroxyindole
C05579  Indole-5,6-quinone
C05580  3,4-Dihydroxymandelate
C05581  3-Methoxy-4-hydroxyphenylacetaldehyde
C05582  Homovanillate
C05583  3-Methoxy-4-hydroxyphenylglycolaldehyde
C05584  3-Methoxy-4-hydroxymandelate
C05585  Gentisate aldehyde
C05587  3-Methoxytyramine
C05588  L-Metanephrine
C05589  L-Normetanephrine
C05593  3-Hydroxyphenylacetate
C05594  3-Methoxy-4-hydroxyphenylethyleneglycol
C05595  4-Hydroxyphenylacetylglutamic acid
C05596  p-Hydroxyphenylacetylglycine
C05600  2-Hydroxyhepta-2,4-dienedioate
C05604  2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
C06044  4-Hydroxyphenylethanol
C06046  Salidroside
C06047  Stizolobate
C06048  Stizolobinate
C06199  Hordenine
C06201  2,4-Dihydroxyhept-2-enedioate
C10447  3,4-Dihydroxyphenylpropanoate
C17935  Cysteinyldopa
C17936  Phaeomelanin
C17937  Eumelanin
C17938  5,6-Indolequinone-2-carboxylic acid
C22038  (R)-3-(3,4-Dihydroxyphenyl)lactate
Reference
PMID:8550403
  Authors
Prieto MA, Diaz E, Garcia JL.
  Title
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
  Journal
J Bacteriol 178:111-20 (1996)
DOI:10.1128/JB.178.1.111-120.1996
Reference
PMID:1194238
  Authors
Sparnins VL, Dagley S.
  Title
Alternative routes of aromatic catabolism in Pseudomonas acidovorans and Pseudomonas putida: gallic acid as a substrate and inhibitor of dioxygenases.
  Journal
J Bacteriol 124:1374-81 (1975)
DOI:10.1128/JB.124.3.1374-1381.1975
Reference
PMID:18435614
  Authors
Ito S, Wakamatsu K
  Title
Chemistry of mixed melanogenesis--pivotal roles of dopaquinone.
  Journal
Photochem Photobiol 84:582-92 (2008)
DOI:10.1111/j.1751-1097.2007.00238.x
Reference
PMID:11171088
  Authors
Olivares C, Jimenez-Cervantes C, Lozano JA, Solano F, Garcia-Borron JC
  Title
The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase.
  Journal
Biochem J 354:131-9 (2001)
DOI:10.1042/bj3540131
Related
pathway
tup00020  Citrate cycle (TCA cycle)
tup00360  Phenylalanine metabolism
tup00400  Phenylalanine, tyrosine and tryptophan biosynthesis
tup00620  Pyruvate metabolism
tup00650  Butanoate metabolism
KO pathway
ko00350   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (39)   
   KEGG GENES (39)   
All databases (40)   

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