Entry
Name
Allograft rejection - Ursus arctos horribilis (North American brown bear)
Description
Allograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of antigen presentation. In the direct pathway, recipient T cells react to intact allogeneic MHC molecules expressed on the surface of donor cells. This pathway would activate host CD4 or CD8 T cells. In contrast, donor MHC molecules (and all other proteins) shed from the graft can be taken up by host APCs and presented to recipient T cells in the context of self-MHC molecules - the indirect pathway. Such presentation activates predominantly CD4 T cells. A direct cytotoxic T-cell attack on graft cells can be made only by T cells that recognize the graft MHC molecules directly. Nontheless, T cells with indirect allospecificity can contribute to graft rejection by activating macrophages, which cause tissue injury and fibrosis, and are also likely to be important in the development of an alloantibody response to graft.
Class
Human Diseases; Immune disease
BRITE hierarchy
Pathway map
Ortholog table
Organism
Ursus arctos horribilis (North American brown bear) [GN:
uah ]
Gene
113249452 HLA class I histocompatibility antigen, A-11 alpha chain-like isoform X1 [KO:K06751 ]
113250163 saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751 ]
113264228 LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-3 alpha chain [KO:K06751 ]
113243704 DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751 ]
113243706 HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751 ]
113243878 LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-32 alpha chain-like [KO:K06751 ]
113261534 H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751 ]
113252170 CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413 ]
113262825 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
113258968 FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
113243684 LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752 ]
113243685 LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752 ]
113243774 HLA class II histocompatibility antigen, DR alpha chain [KO:K06752 ]
113243775 DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752 ]
113243776 SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752 ]
113243777 HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752 ]
113243778 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
113243779 HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752 ]
113243784 HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752 ]
113243786 HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752 ]
113243788 HLA class II histocompatibility antigen, DO alpha chain [KO:K06752 ]
113258674 CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
Compound
Reference
Authors
Arakelov A, Lakkis FG.
Title
The alloimmune response and effector mechanisms of allograft rejection.
Journal
Semin Nephrol 20:95-102 (2000)
Reference
Authors
Le Moine A, Goldman M, Abramowicz D.
Title
Multiple pathways to allograft rejection.
Journal
Reference
Authors
Trivedi HL.
Title
Immunobiology of rejection and adaptation.
Journal
Reference
Authors
Pietra BA.
Title
Transplantation immunology 2003: simplified approach.
Journal
Reference
Authors
Oka T, Yoshimura N.
Title
Immunosuppression in organ transplantation.
Journal
Reference
Authors
Sayegh MH.
Title
Why do we reject a graft? Role of indirect allorecognition in graft rejection.
Journal
Reference
Authors
Benichou G.
Title
Direct and indirect antigen recognition: the pathways to allograft immune rejection.
Journal
Reference
Authors
Turvey SE, Wood KJ.
Title
Immunobiology of solid organ transplantation.
Journal
Int Surg 84:279-90 (1999)
Reference
Authors
Janeway CA, Travers P, Walport M, Shlomchik MJ.
Title
Immunobiology 6th edition
Journal
Garland Science Publishing (2005)
Reference
Authors
Game DS, Lechler RI.
Title
Pathways of allorecognition: implications for transplantation tolerance.
Journal
Reference
Authors
Lechler RI, Garden OA, Turka LA.
Title
The complementary roles of deletion and regulation in transplantation tolerance.
Journal
Related pathway
uah04610 Complement and coagulation cascades
uah04612 Antigen processing and presentation
uah04660 T cell receptor signaling pathway
uah04662 B cell receptor signaling pathway
KO pathway